Synaptic Synaptic TransmissionTransmission

Electrical & Chemical Electrical & Chemical SynapsesSynapses

Events Involved in Transmission at a Events Involved in Transmission at a Chemical SynapseChemical Synapse

Local Recycling of Synaptic Vesicles in Local Recycling of Synaptic Vesicles in Presynaptic TerminalsPresynaptic Terminals

Presynaptic Proteins Implicated in Presynaptic Proteins Implicated in Neurotransmitter ReleaseNeurotransmitter Release

Molecular Mechanisms of Neurotransmitter Molecular Mechanisms of Neurotransmitter ReleaseRelease

Molecular Mechanisms of Neurotransmitter Molecular Mechanisms of Neurotransmitter ReleaseRelease

Diseases that Affect the Presynaptic TerminalDiseases that Affect the Presynaptic Terminal

Lambert-Eatonmyasthenic syndrome= Ab mediated

Several congenital forms result infewer or smaller vesicles= less transmitter

Toxins That Affect Transmitter Toxins That Affect Transmitter ReleaseRelease

Toxins cleave SNAREs

Tetanus affects inhibitory interneurons = hyperexcitation of muscles

Botulism paralyzes peripheral muscles = do not contract

Toxins That Affect Transmitter Toxins That Affect Transmitter ReleaseRelease

Black widow venom = exocytosis w/o calcium

Binds to CL1 and neurexin,neurexin binds to synaptotagmin

Diseases Caused by Altered Ion Diseases Caused by Altered Ion ChannelsChannels

FHM = familial hemiplegic migraine

EA2 = episodic ataxia

CSNB = congenital stationary night blindness