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0022-202X/79/7306-0589$02.00/0 THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, 73:589-591, 1979 Copyright © 1979 by The Williams & Wilkins Co.
A
A cid arachidonic transformations with, in nor
mal and psoriatic skin, 180 fatty
in skin surface lipids, effects of aging on, 112
picogram levels, detection of Neisseria gonorrhoea, 521
Acid phosphatase, psoriatic scales, 554 Acne, research needs in, 434 Aging, 1
cell biology of, 8 cellular
immunity in, 24 in Werner's syndrome, unique pheno
type, 92 chronic sun exposure and, effects on mel
anocytes in human skin, 141 cutaneous
perspectives and problems in, 39 structural changes in, 47
effects on fatty acids in skin surface lipids, 112 melanocytes, chronic sun exposure and,
141 rate of linear nail growth, 126 steroid hormone metabolism in skin
and isolated sebaceous glands, 118 environmental influences and photocar
cinogenesis in, 131 human skin, changes in mechanical prop-
erties related to, 84 immunologic, thymus as clock for, 29 mitochondrial lipoperoxidation and, 123 of collagen, 80 of melanocytes, 70 photocarcinogenesis and environmental
influences in, 131 research
current and future, 2 needs in,485
sebaceous gland activity changes in, 108 structural a lterations in
exposed skin, 59 unexposed human skin, 59
unexposed human dermis, model for, 54 wound healing and, .88
Alkali extraction, combined with ethidium bromide, technique for measurement of tissue DNA, 359
Alopecia areata, direct immunofluorescence of, 317 male pattern, direct immunofluorescence
of,317 Amyloidosis, cutaneous
primary localized, histogenesis of, 150 sequential change of epidermal keratino
cytes to amyloid via fIlamentous degeneration, 150
Antibodies drug specific, role of enzymatic coupling
of drugs to proteins in induction of, 256
pemphigus, appearance of "pemphigus acantholysis factor" in human skin cultured with, 575
wheat protein, in dermatitis herpetiformis , 570
Aprotinin, ineffectiveness of, on psoralen-
SUBJECT INDEX
UVA-(PUVA)-induced erythema, 527
B
Bil·th defects, research needs in, 460 Blister fluid, suction, lipids and proteins in,
determination of, 303 Bullous pemphigoid
demonstration of complement regulating protein, ,BIH, in skin biopsies from patients with, 551
serum eosinophil chemotactic factor levels in, 163
4-[3-Butoxy-4-methoxybenzyIJ-2-imidazolidinone, treatment of psoriatic lesions, double-blind trials, 261
C
Cholinesterase isoenzymes, skin and plasma, comparison, 239
Clonal priming, direct in vitro assessment of autologous HLA-associated factors required for immune response to dinitrochlorobenzene, 246
Collagen aging of, 80 type IV, in protoporphyria, 335
Complement, serum, activation, purification of mamman from Candida albicans for, 269
Connective tissue disease, research needs in, 485
Corneocytes, psoriatic, surface area measurements, effects of intralesional steroid therapy, 558
Cyclic GMP, epidermis effect of ischemia on, 220 histamine stimulated formation, 313
D
Dermatitis herpetiformis failure to detect gliadin or gliadin binding
sites in, 174 wheat protein antibiodies in, 570
Dermatogerontology, exfoliative cytologic procedures as nonintrusive method of,67
Dermatological diseases, prevalence, morbidity and cost of, 395
Dermatopharmacology, research needs in, 473
Dermatophyte, experimental lesions, production of, 198
Dermis dithiothreitol separation of, 207 unexposed human, aging model for, 54
7, 12-Dimethylbenz(a)antracene, and UVB effect on epidermal melanocytes, 538
Dinitrochlorobenzene, in vitro assessment of autologous HLA-associated factors required for immune response to, 246
Dithiothreitol, separation of newborn rodent dermis and epidermis with, 207
DNA cytophotometry, lymph node imprints
from patients with mycosis fungoides, 275
epidermal keratinocytes, repau' of ultraviolet light damage to, 217
fibroblasts, repair of ultraviolet light damage to, 217
589
Vol. 73, No.6 Printed in U. S. A.
interaction with 8-methoxypsoralen, LIt
vitro, 191 phage lambda, interstrand crosslinks in,
after exposure to 8-methoxypsoralen and trimethylpsoralen in light, 236
repair processes, protection of premature solar damage by, evidence in xeroderma pigmentosum, 102
tissue, measurement, combined alkali extraction-ethidium bromide technique for, 359
Drug reactions, serum eosinophil chemotactic factor levels in, 163
Dyskeratosis congenita, psoralen-DNA cross-linking photoadducts in, delay in excision and promotion of sister chromatid exchange, 97
E
Eczema, atopic inlpaired H2 histamine granulocyte re
sponse in, 184 research needs in, 414 serum eosinophil chemotactic factor
levels in, 163 EDCI, in psoriasis, 264 Elu triation, lymphocyte function after, com
pared with ficoll-hypaque flotation, 231
Envu"onmental agents, skin reaction to, research need in, 501
Enzymatic coupling, drugs to proteins, role of, in induction of drug specific antibodies, 256
Eosinophil, serum, chemotactic factor levels in bullous pemphigoid, drug reactions and atopic eczema, 163
Epidermis comparative ultrastructure and cyto
chemistry of response to tape stripping, ethanol and vitamin A acid in hairless mice, 203
cycl ic GMP system effect of ischemia on, 220 histamine stimulated formation, 313
dithiothreitol separation of, 207 a-fucosidase, multiple forms of, 288 ,B-galactosidase, heterogeneity, newborn
rat, 285 living, epidermal cell cultures as models
for, 135 Erythema, psora len-UVA-(PUVA)-in-
duced, aprotinin ineffectiveness on, 527
Erythrocyte conjugates of hapten, in vitro and in vivo detection of, 166
Ethanol, ultrastructure and cytochemistry of epidermal response to, hairless mice, 203
Ethidium bromide, combined with alkali extraction, technique for measurement of tissue DNA, 359
Eumelanogenesis, in retinal and follicular melanocY,tes, compared with pheomelanogenesis, 278
European Society for Dermatological Reseru'ch, 9th annual meeting
minutes, 583 presidential address, 582
Exfoliation, agents for, effect on rhino mouse skin, 354
590 SUBJECT INDEX
F
Fibrin, deposition and clearance, in chronic granulomatous inflammation, correlation with T-cell function, and proteinase inhibitor activity in tissue, 561
Fibroblasts cultured skin
age-related diseases in, 19 aging and, 15
photo inactivation of, by frationated treatment with 8-methoxypsoralen and long wave ultraviolet light, 176
ultraviolet light damage to DNA of, repair,217
Ficoll-hypaque flotation, lymphocyte function after, compared with elutriation, 231
Follicular casts, inflammatory mediators in, method for assay of, 266
a-Fucosidase epidermal, multiple forms of, 288 psoriatic scales, 554
G
IJ-Galactosidase, heterogeneity, newborn rat epidermis, 285
Genetic disorders, research needs in, 460 Gerontology; cutaneous, perspectives and
problems in, 39 Gliadin, failure of detection, in dermatitis
herpetiform is, 174 Glycoprotein
cancer-related, accumulation, urinary, in psoriasis, 264
non collagenous, in protoporphyria, 335 Goeckerman regimen, components of, 170 Granulocyte, impaired H2 histamine re
sponse in active atopic eczema, 184 Granulomatous inflammation, chronic, fi
brin deposition and clearance in, correlation with T-cell function and proteinase inhibitor activity in tissue, 561
H
Hapten, erythrocyte conjugates, detection of in vitro and in vivo, 166
Histamine . impaired granulocyte response, in active
atopic eczema, 184 stimulation of cyclic GMP in epidermis,
313 Histometric analysis, human skin in organ
culture, 138 3-Hydroxy fatty acids, picogram levels, de
tection of Neisseria gonorrhoea, 521
I
Immunity, cellular, in aging, 24 Immunologic aging, thymus as clock for, 29 Immunologic disease, research needs in, 414 Infections, dermatologic, research needs in,
452 Instrumentation, dermatologic, research
needsin,473 Ischemia, effect on cyclic GMP system of
epidermis, 220 Isoenzymes, cholinesterase, skin and
plasma, comparison, 239
K
Karyotype, cutaneous T cell lymphoma, clonal origin, 548
Keratinization, agents for, effect on rhino mouse skin, 354
Keratinocytes epidermal, ultraviolet light damage to
DNA of, repair, 217 sequential change to amyloid via fllamen
tous degeneration, in cutaneous amyloidosis, 150
Kinin-forming enzyme, human skin, purification and characterization of, 297
L
Langerhans cells, epidermal, kinetics of, 566 Letter to edi tor
chronic Trichophyton I'ubrum infection and blood groups, 392
reactive hyperemia in scleroderma, 259 regional variation of immunoglobulin de
posits in NZB/W FI mice, tail-end suggestion, 392
tyrosine hydroxylation, 392 Lichen planus, changes in carbohydrate
expression of, in oral epithelial cell membranes, 364
Light, ultraviolet and 7, 12-dimethylbenz(alantracene, ef
fect on epidermal melanocytes, 538 damage to DNA of cultured human epi
dermal keratinocytes and fibroblasts, repair of, 217
effect on sunburn cell production, 243 local and systemic effects on epidermal
. melanocyte population, 306 modulation of prostaglandin E2 binding to
human skin membranes, 373 photoinactivation of skin fibroblasts, 176 psoralen and, induction of erythema, in
effectiveness of aprotinin on, 527 Lipids
in suction blister fluid, determination of, 303
localization and composition of, in neonatal mouse stratum granulosum and stratum corneum, 339
skin surface, fatty acids of, effect of aging on, 112
Lipoperoxidation, mitochondrial, in human skin, age-related, 123
Lupus erythematosus, systemic, concurrent linear scleroderma and, report of two cases, 368
Lymph node imprints, DNA-cytophotometry of, from patients with mycosis fungo ides, 275
Lymphocyte function, after isolation by ficoll-hypaque
flotation or elutriation, 231 6-thioguanine resistance of, after photo
chemotherapy, 211 Lymphoma, T cell , cutaneous, karyotype
studies 0'[, evidence for clonal origin, 548
M
Malassezia furfur, and immunological studies on Pityrosporum genus, 321
Mannan, for activation of serum complement, purification of, from Candida albicans, 269
a-Mannosidase, psoriatic scales, 554 Melanocytes
aging of, 70 epidermal, effects of
psoralen and UVA (PUV A) on, 533 UVB and 7,12-dimethylbenz(a)antra
cene on, 538 extracellular sheath of, in nevus fuscocer
uleus acromiodeltoideus and Mongolian spot, ultrastructure, 224
human skin, effects of aging and chronic sun exposure on, 141
local and systemic effects of UV-irradiation, 306
Vol. 73, No.6
retinal and follicular, eumelanogenesis and pheomelanogenesis, 278
Melanoma, malignant, research needs in, 491
Melanosome, differentiation, role of vesiculo-globular bodies in, 278
Merkel cell, specialized junction with neurite, electron microscopy, 325
Methoxasalen, chronic photosensitization with, dermatological and ocular examination after, 250
8-Methoxypsoralen interaction with DNA, in vitro, 191 interstrand crosslinks in DNA of phage
lambda after exposure to, 236 photo inactivation of skin fibroblasts and,
176 Mitochondria, lipoperoxidation, in human
skin, age-related, 123 Monocyte function, in psoriasis, 147 Mongolian spot, extracellular sheath of der
mal melanocytes in, 224 Musk ambrette, assay of contact photosen
sitivity to, guinea pig, 144 Mycosis fungoides, DNA-cytophotometry of
lymph node imprints in, 275
N
Nail growth, linear, rate of, effects of aging on, 126
Neoplasms, research needs in benign, 443 malignant, 443
Neurite, specialized junction with Merkel cell, electron microscopy, 325
Nevus fuscoceruleus acromiodeltoideus, extracellular sheath of dermal melanocytes in, 224
P
Papilloma virus 3, in warts of renal allograft patient, characterization of, 349
Pemphigoid, bullous demonstration of complement regulating
protein in skin biopsies from patients with,551
serum eosinophil chemotactic factor in, 163
Pemphigus acantholysis factor, appearance of, in human skin cultured with pemphigus antibody, 575
Phagocytic chemotaxis, 515 Pheomelanogenesis, in retinal and follicular
melanocytes, compared with eume-lanogenesis, 278
Photocarcinogenesis, aging and environmental influences, 131
Photochemotherapy suppression of proliferative stimulus pro
duced by stripping on hairless mice, 188
6-thioguanine resistant peripheral blood lymphocytes after, 211
Photosensitization chronic, with methoxsalen, dermatologi
cal and ocular examination after, 250 contact, to musk ambrette, assay of, 144
Pityrosporum, immunological studies, and Malassezia furfur, 321
Preputial gland cells, isolation, separation and characterization, in sebaceous gland differentiation, 291
Propranolol, differential induction of abnormal proliferation of uninvolved psoriatic epidermis, 545
Prostaglandin E 2, specific binding to membranes from human skin, receptor modulation by UVB-irradiation and chemical agents, 373
December 1979
Prote in complement regulat ing, demonstration of,
in skin biopsies from pat ients with bullous pemphigoid, 551
in suction blister fluid, determination of, 303
wheat, ant ibodies of, in dermatitis herpetiformis, 570
Prote inase inhibi tor activi ty, T-cell function and, correlation with fibrin deposition and clearance in chronic granulomatous inflammation, 561
P rotoporphyria, type IV collagen and noncollagenous glycoprotein in thickened vascular basal membrane in, 335
Pruritus, pain and, research need in, 495 Psoralen
DNA, cross- linking photoadducts in dyskera tosis congenita, delay in excision and promotion of sister chromatid exchange, 97
effects of, with UV A on epidermal melanocytes, 533
6-thioguanine resistant peripheral blood lymphocytes and, 211
wi th UVA, induction of erythema, ineffectiveness of aprotinin on, 527
Psorias is abnormal prolifera tion of uninvolved epi
dermis, differential induction by saline, propranolol , and tape stripping, in vivo, 545
accumulation of urinary cancer-related glycoprotein in, 264
arach idonic acid transformations in, 180 corneocytes of, surface area measure
ments, effec ts of intralesional steroid therapy on, 558
Goeckerman regimen components, 170 monocyte function in, 147 multiple forms and glycoprote in nature of
ac id phosphatase, a-fucosidase and a-mannosidase of scales of, 554
reseaJ'ch needs in, 402 Ro 20- 1724 treatment, double-blind clini
cal t rials, 261
R
Reviews of Books and Audiovisual Aids Botanical Dermatology, 584
Cancer Dermatology, 584 Clinical Shin Microbiology, 202 Gross and Microscopic Pathology of the
Shin, 584 Les Affections Dennatologiques en
O.RL. and Reparations Plastiques des Pertes de Substances Cutanee de la Face, 202
Metabolic Basis of Inherited Disease, 584 Physiology and Pathology of the Shin,
Vol. 5: Sweat Glands, Sllin Permeation, Lymphatics, Nails, 585
Sexually Transmitted Diseases, 202 UV-A: Biological Effects of Ultraviolet
Radiation with Emphasis on Human Response to Longwave ULtraviolet, 202
Ro 20-1724, treatment of psoriatic lesions, double-blind clinical trials, 261
s Saline, differential induction of abnormal
prolifera tion of uninvolved psoriatic epidermis, 545
Scleroderma, linear, concurrent systemic lupus erythematosus and, report of two cases, 368
Sebaceous gland age-related changes in, 108 differentiation, preputia l gland cells, 291
Sensitization, contact simple chemical, 246 Society for Investigative Dermato logy, Inc.,
May 7-9, 1979, annual meeting, min-utes of, 373
Steroid hormone metabolism, in skin and isolated
sebaceous glands, effects of age on, 118
therapy, effect on surface area measurements of psoriatic corneocytes, 558
Stratum corneum, lipids in, localization and . composition of, 339
Stratum granulosum lipids in, localization and composition of, 339
Sun exposure, chronic, aging and, effects on melanocytes in human skin, 141
Sunburn cell production, longwave ultraviolet radiation effect on, 243
Sweating disorders, research need in, 495
SUBJECT INDEX 591
T
T cell function, proteinase inhibitor activity in
tissue and, correlation with fibrin deposition and clearance in chronic granulomatous inflammation, 561
lymphoma, cutaneous, karyotype studies of, evidence for clonal origin, 548
T ape stripping differential induction of abnormal prolif
eration of uninvolved psoriatic epidermis, 545
ultrastructure and cytochemistry of epidermial response to, 203
6-Thioguanine, peripheral blood lymphocyte resistance to, after psoralen, long wave ul traviolet light therapy, 211
Thymus, as clock for immunologic aging, 29 Trimethylpsoralen, interstrand crosslinks in
DNA of phage lambda after exposure to, 236
Tyrosine metabolism, hepatic enzymes of, in tyrosinemia II, 530
Tyrosinemia II, hepatic enzymes of tyrosine metabolism in, 530
v
Vitamin A, ultrastructure and cytochemistry of epidermal response to, hairless mice, 203
Vitiligo, research needs in, 491
w
Warts, renal a llograft patient, papiJlomavirus 3 in, characterization of, 349
Werner's syndrome, cellular aging in, unique phenotype, 92
Wound healing, aging and, 88
x
Xeroderma pigmentosum, evidence for DNA repair processes protecting from premature solar damage, 102