Slides of the Slides of the weekweek

Squamous cell carcinomaSquamous cell carcinoma Origin:Origin: Squamous epithelium.Squamous epithelium. SitesSites:: Skin, Oral cavity, Cervix.Skin, Oral cavity, Cervix. GrossGross: : Irregular growth Irregular growth fungating, fungating,

infiltrating or ulcerating growth.infiltrating or ulcerating growth. MicroscopicallyMicroscopically: : Masses and sheets of Masses and sheets of

malignant squamous epithelial cells malignant squamous epithelial cells containing keratin nests and separated by containing keratin nests and separated by C.T.stroma which infiltrated with C.T.stroma which infiltrated with inflammatory cells.inflammatory cells.

GradingGrading: : depends on , % of keratin nests, depends on , % of keratin nests, mitoses and irregular nuclear patternmitoses and irregular nuclear pattern

Squamous cell carcinoma, Squamous cell carcinoma, SkinSkin

Squamous cell carcinomaSquamous cell carcinomaSole of the footSole of the foot

SCC

SQUAMOUS CELL CARCINOMA

Squamous cell carcinomaSquamous cell carcinoma

AdenocarcinomaAdenocarcinoma OriginOrigin: : glandular tissue.glandular tissue. SitesSites: : endocrine, exocrine glands, mucus endocrine, exocrine glands, mucus

membranes, GIT, endometrium.membranes, GIT, endometrium. GrossGross: : in solid organsin solid organsirregular infiltrative irregular infiltrative

growth, in hollow organsgrowth, in hollow organsfungating, fungating, infiltrating or ulcerating growth.infiltrating or ulcerating growth.

MicroscopicallyMicroscopically: : irregular glands in size irregular glands in size and shape,lined by malignant cells and and shape,lined by malignant cells and separated by C.T. stroma.separated by C.T. stroma.

GradingGrading: : depends on tubule formation, depends on tubule formation, number of mitoses and irregular nuclear number of mitoses and irregular nuclear pattern.pattern.

Adenocarcinoma,Adenocarcinoma,coloncolon

Adenocarcinoma colon

Adenocarcinoma colon

Adenocarcinoma colon

Grading of malignant Grading of malignant TumoursTumours

Mucoid carcinomaMucoid carcinoma Origin:Origin: from from glandular epithelium.glandular epithelium. Sites:Sites: mostly in GIT.mostly in GIT. GrosslyGrossly:: appears as soft gelatinous mass.appears as soft gelatinous mass.

Microscopicaly:Microscopicaly: 1-Mucoid carcinoma1-Mucoid carcinoma: : mucoid differentiation mucoid differentiation

in an adenocarcinoma in an adenocarcinoma rupture of cells rupture of cells release of large amount of extra-cellular release of large amount of extra-cellular mucin.mucin.

2-2-Signet cell carcinomaSignet cell carcinoma: : cells are cells are distended with intracellular mucin--. Signet distended with intracellular mucin--. Signet ring cells with minimal extrapcellular mucinring cells with minimal extrapcellular mucin..

Mucoid carcinoma, colon

Signet ring carcinoma, Signet ring carcinoma, StomachStomach

Basal cell crcinomaBasal cell crcinoma(Rodent ulcer)(Rodent ulcer)

Def:Def: locally malignant tumor arising from locally malignant tumor arising from the basal cell layer of epidermis.the basal cell layer of epidermis.

Sites: skin areas exposed to sun as in face.Sites: skin areas exposed to sun as in face. Gossly:Gossly: starts as a papule starts as a papule rodent ulcer rodent ulcer

( raised everted edge,rough and necrotic ( raised everted edge,rough and necrotic floor, indurated edge).floor, indurated edge).

HistologicallyHistologically:: invasion of the dermis invasion of the dermis by variable sized masses formed of by variable sized masses formed of malignant basaloid cells that form palisade malignant basaloid cells that form palisade appearance at the periphery.appearance at the periphery.

Basal cell carcinomaBasal cell carcinoma, , FaceFace

Basal cell carcinoma, Basal cell carcinoma, FaceFace

Basal cell carcinoma