Serbia - ItaliaSerbia - Italia Bilateral CooperationBilateral Cooperation

ACETYLCHOLINESTERASE ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF INHIBITORY ACTIVITY OF

THIO-AVAROL DERIVATIVESTHIO-AVAROL DERIVATIVES

25th and 26th June, 201225th and 26th June, 2012

BeogradBeograd

Pozzuoli - NapoliPozzuoli - Napoli

The SpongesThe Sponges

Dysidea avara

Dr. Salvatore De RosaDr. Salvatore De Rosa

Dirigente di RicercaDirigente di Ricerca

National Research Council of ItalyInstitute of Biomolecular Chemistry

CNR-ICBCNR-ICB

E-mail: sderosa@icb.cnr.it

Dr. Giuseppina Tommonaro Ricercatore

National Research Council of ItalyInstitute of Biomolecular Chemistry

CNR-ICB

E-mail: gtommonaro@icb.cnr.it

Mr. Carmine IodiceCollaboratoreTecnico ente di Ricerca

National Research Council of ItalyInstitute of Biomolecular Chemistry

CNR-ICB

E-mail: ciodice@icb.cnr.it

Avarol is a marine sesquiterpene

hydroquinone possesing a rearanged drimane skeleton.

Avarone is the quinone form of avarol.

Avarol

Avarone

Avarol was found to have

anti-inflammatory antipsoriatic antioxidant antitumor

antiplatelet analgesic anti-HIV

activities.

Of particular interest isacetylcholinesterase inhibitory

activity of thio-avarol derivatives with a carboxylic group in the

molecule, such as

avarol-3‘-thiobenzoate avarol-3‘–thiolactateavarol-4‘–thiolactate

TLC bioautographic assay(white spot on a purple background)

1 μg

Galanthamine was used a positive control.

Galanthamine 0.01 μg

NO

HO

O

H

Dr. Pietro AmodeoDr. Pietro AmodeoI RicercatoreI Ricercatore

National Research Council of ItalyInstitute of Biomolecular Chemistry

CNR-ICBCNR-ICB

E-mail: pamodeo@icb.cnr.it

Dr. Rosa Maria VitaleRicercatore

National Research Council of ItalyInstitute of Biomolecular Chemistry

CNR-ICB

E-mail: rmvitale@icb.cnr.it

Binding properties of avarol and its inhibitory derivatives to the

enzymehave been characterising by

computationalapproach.

This research aims to design new avarol

derivatives which better inhibitacetylcholinesterase.

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