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SECRETS OF PARASITES' REPLICATION UNRAVELEDAND PROTEIN INVOLVED IN DNA REPLICATION, CENTROSOME REGULATION LINKED TO DWARFISM, SMALL BRAIN SIZE
Carolina Jaramillo Mesa
Medical student UPB
ID: 00012039
Molecular biology
August 6 2012
INTRODUCTION Recognition of ORI
(Origin of replication)
Helicase
DNA unroll
DNA polymerase
DNA replicateReparation of
DNA
Mutation
Conservation and transmition of the DNA
Trypanosoma brucei it’s a parasite type kinetoplastia, wich have the mtDNA encapsulated in the mithocondrion with many copies of the mitochondrial genome. This parasite cause African sleeping sickness.
Taken from: http://www.microbiologyonline.org.uk/about-microbiology/introducing-microbes/protozoa
Taken from: http://www.parasitemuseum.com/trypanosome/
DNA circlesDNA
polymerase
Copy the informatio
n
Daughter cells
Relationship with replicating kDNA molecules
Experiment Inmunofluorescen
ce
DNA polymerase ID
Localization of DNA polymerase
ID
STUDENT CONCEPT
This parasites cant be eradicate with antibiotics by the complex mitochondrial genome and the only way to kill them is using toxics. This research proposed a alternative treatments more effectivs and less agresives.
Meier-Gorlin syndrome : it is characterized for severe growth defects, skeletal abnormalities and small brain size.
Taken from http://abbottgenetics.wordpress.com/2009/03/09/why-the-littlest-angel-was-so-little-by-bryan-cooke/
ORC recognize the ORI to start the DNA replication and coordinate that the genetic material duplicate just once. Also ensure the correct duplication of the genetic material through centrosome.
Taken from: http://www.intechopen.com/books/dna-replication-current-advances/the-silencing-face-of-dna-replication-gene-repression-mediated-by-dna-replication-factors
pre-RC recognize the ORI
DNA replicaction
Regulation of the centrosome
Orc1-encoding gene is mutated
Reduplication of the centrosome
alteration of the cell cycle and cell signaling
Meier-Gorlin syndrome
STUDENT CONCEPT Knowing the causes of the disease allow
us treat this mutation before its expression, through genetic therapy with the objective to prevent the damage and in a future decrease the number of kids with Meier Gorlin syndrome.
Taken from: http://www.fedaes.es/FOLLFA/B14-TERA.htm
This research expose us alternative treatments to diseases as complicated as those caused by parasites, African sleeping sickness, Chagas disease and leishmaniasis and understand the cellular processes that take place in these diseases.
The genetic diseases have increased with the pass of the years, they are misunderstood because the cause of them are unknown in the most part of cases and the treatment are very limited, so as a doctors is very important inform about this diseases and exposed our patients the alternatives treatments and the explain them all about this diseases.
Taken from: http://www.sitiosespana.com/notas/2010/mayo/oligofrenia.htm
BIBLIOGRAPHY MARTINEZ, Lina; Biologia molecular, Vol
6. ed. UPB, 2011. Paginas 74-81. Secrets of Parasites' Replication
Unraveled; Sciencedaily; july 9 2012; http://www.sciencedaily.com/releases/2012/07/120710141940.htm
Protein Involved in DNA Replication, Centrosome Regulation Linked to Dwarfism, Small Brain Size; Sciencedaily; July 31 2012; http://www.sciencedaily.com/releases/2012/07/120731200628.htm