Post on 25-Dec-2015
RNA, ribonucleic acid
single strand polymers of ribonucleotides
have secondary and tertiary structure
Classification of RNATypes function
ribosomal RNA (rRNA)messenger RNA (mRNA)transfer RNA (tRNA)heterogeneous nuclear RNA(hnRNA)small nuclear RNA(snRNA)
small nucleolar RNA (snoRNA)small cytoplasmic RNAribozymemicroRNA (miRNA)
small interfering RNA (siRNA)non-coding RNA (ncRNA)
component of ribosometemplate of protein synthesistransfer amino acidpremature mRNA
participate the splicing and transfer of hnRNA, includes spliceosomal RNAprocess and modify rRNA
recognize the protein sorting signalcatalytic RNAusually endogenous, induce degradation of targeted mRNA usually exogenous, induce degradation of targeted mRNAall RNA other than mRNA, priorly functional RNA longer than 200nt
mRNA
Processing of mRNA Structure of mRNA
hnRNAm7Gppp
AAA….An
5’ 3’AUGGUG……………………………UAA5’-cap 5’ UTR coding region 3’ UTR 3’ poly(A) tail
triplet code or codon
mRNA(cont.)
The process of mRNA is on the base of hnRNP 5’-cap and 3’ poly(A) play a role in the translocation
of mRNA (from nuclear to cytoplasm), stability, control of protein translation.
Life Cycle of an mRNA