5%

Birth

Hearing loss

Hypertension

Obesity

Smoking

Depression

Physical inactivity

Low social contact

Diabetes

8%

9%

5%

4%

3%

2%

1%

2%

1%

7%

Less education

Potentiallynon-modifiable

65%

Potentiallymodifiable

35%

Late life

Midlife

Early lifeHearing loss

Percentage reduction in new cases of dementiaif this risk is eliminated

HypertensionObesity

Smoking

DepressionPhysical inactivity

Social isolationDiabetes

8%

9%

5%

%

4%

3%

2%

1%

2%

1%

7%

Less education

Potentiallynon-modifiable

65%

Potentiallymodifiable

35%

The best science for better lives

The Lancet Commission presents a new life-course model showingpotentially modifiable, and non-modifiable, risk factors for dementia.

ApoE ε4 allele

Risk factors for dementia