by

International Trade and Marketing CEO Dr. Amr M. Helal

Rice Bran Nutraceuticals

from Waste material

to Products for Healthy aging

Dream or Reality

Before we starts

Numbers Never Lies

List of exporters for the selected product in 2013

Product : 1211 Medicinal plants

Value exported in 2013

(USD thousand) Trade balance in 2013 (USD thousand)

World 3,399,350

China 1,196,725

India 207,758

Canada 184,930

United States of

America 168,286

Germany 148,372

Egypt 109,845

Korea, Republic of 109,379

List of exporters for the selected product in 2013 Product : 30 Pharmaceutical products

Trade Indicators

Value exported in 2013 (USD

thousand) Trade balance in 2013 (USD thousand)

World 486,308,192

Germany 73,779,288

Israel 6,099,722

Best Investment !

On going Success Story Supported by EU- RDI

Egyptian Partners

German University in Cairo Faculty of Pharmacy Cairo U. National Research center Agriculture Research Center Health Tech Al Sonbolah Rice Mill International Trade and

marketing

EU Partners

Goethe University Muenster University VIVA cell Biotechnology FB- Food Germany Analyze and realize (a&r) Baspharma Holland Holland Food Trade Ainia (Spain)

Rice Bran

in Egypt

Total Rice cultivated area

>1.5 Million Acers

> 500,000 MT Rice bran

Rice Milling Processes

Husk removed Bran removed

is one of the most nutritive ingredients of the rice crop, where about 60% of the total nutritive value of rice itself resides

Rice Bran

PROTEIN

OIL DIETARY

FIBRE

VITAMINS &

MINERALS

GAMMA

ORYZANOL

ANTIOXIDANTS

TRACE

ELEMENTS

RICE BRAN

These components can be obtained from other sources in nature separately, but Rice Bran is unique in having them all

Rice Bran Nutraceutical / Functional Food Values

Potent

Antioxidant

High Nutritional Value

Blood

Pressure

Blood

Cholesterol

Potential benefits of RICE BRAN

Blood Sugar

However due to non stabilization of Rice Bran; it is still discarded or used as animal feed despite its high content of bioactive substances.

It all starts with IMC support for : RICE BRAN INNOVATIVE STABILIZATION

Project Name Funding Authority Budget

Rice Bran Stabilization Unit (5-7-1) Faculty of Agriculture, Mansoura University 2007-2008

Industrial Modernization Centre (IMC)

70,000 L.E.

Rice Bran Stabilization Industrial Unit (1-12-53) Faculty of Agriculture, Mansoura University 2009-2010

Industrial Modernization Centre (IMC)

700,000 L.E.

Rice Bran Phytochemical Study (3-7-4) National Research Centre 2008-2009

Industrial Modernization Centre (IMC)

100,000 L.E.

Rice Bran Industry Implementation (5-7-2) National Research Centre 2008-2010

Industrial Modernization Centre (IMC)

200,000 L.E.

Rice Bran Nutraceuticals

• Contract Number MED/2008/214-423

• Total cost of the action EURO 192000 (18 months)

• Project PI: Prof. Dr. M.T. Khyyal

• Project Partners: International trade and Marketing IT&M

(Coordinator), Faculty of Pharmacy; German University in

Cairo GUC; Faculty of Pharmacy; Johann Wolfgang Goethe

Unifersirty Frankfurt (GUF) ; VivaCell Biotechnology GmbH

VC (Germany)

• Egyptian rice bran was stabilized immediately after milling to preserve its active constituents.

• An extract (RBEX) was prepared, analyzed phytochemicaly and standardized to contain 2.05 % gamma-oryzanol.

• Other active constituents included tocotrienols, tocopherols and policosanol.

• The extract was used to study the pharmacological properties outlined below with a view of developing nutraceutical formulations.

• RBEX was found to have therapeutic potentials in rheumatic disorders, hypertension, Type 2 diabetes and Alzheimer & neurodegenerative disorders.

POSTER ABSTRACT

Conclusions

Based on present experimental evidence, Egyptian rice bran extract has therapeutic potentials in:

1. Rheumatic disorders: associated with its anti-inflammatory, antioxidant activity and effect on cytokines.

2. Hypertension: related to its antioxidant & hypocholesterolemic activity.

3. Type 2 Diabetes: effect on insulin release and blood glucose.

4. Alzheimer and neurodegenerative disorders: mitochondrial protection.

Rice Bran Extract Safety studies

No genotoxicity up to 200 ug

Normal karyotype. No numerical aberrations, gaps or breaks

Normal karyotype. No translocations

-No signs of acute or sub –chronic oral toxicity was observed over the range of studied doses (2.0, 1.0 and 0.5 g/kg Rice bran oil extract) - The doses selected are 20 , 10 and 5 times above the therapeutic dose. -Some significant histological and biochemical differences were observed at the 2.0g/kg rice bran oil extract -No signs of mutagenicity or genotoxicity was detected for the rice bran oil extract at gene, DNA or chromosomal level using the applied techniques in the present study

Conclusions

Rice Bran Formulations

• Contract Number: RDI2/S2/26

• Total cost of the action: EURO 104000 (15 months)

• Project PI: Dr. Amr M. Helal

• Project Partners and associates:

– Faculty of Pharmacy Cairo University

– Faculty of Pharmacy; Johann Wolfgang Goethe University Frankfurt

– Analyze & Realize, Germany

– BasPharma, The Netherlands

• The overall objective of the project is Innovative formulation for stabilized rice bran extract with maximum therapeutic usefulness for pharmaceutical, food, beverage and cosmetic applications

• And the specific objective(s); Stabilized rice bran prompt extraction at room temperature and spray drying into instant water - soluble formulation.

Products under registration

Stabilized Rice Bran Sachets

Products under registration (Cont.)

RICPLEX

20 Soft Gel capsules

PorridgePlus - a food against dementia

Aim to develop a food product for elderly with the objective to promote healthy brain aging

Aim of the Project: • to develop a food product for elderly with the

objective to promote healthy brain aging.

This project primarily based on the findings that Rice Bran Extract protects from mitochondrial dysfunction in the brain.

• to develop a rice bran extract as a potential food supplement to prevent neurodegeneration

“Together with partners from Egypt”

Nutraceutical Products; Rice Bran Planned products

Rice Bran Spray Dried Powder (Healthy Creamer)

Rice Bran / Ginkgo product range (Capsules – Soluble Powder)

Rice Bran/ Barley product range (Capsules – Soluble Powder)

Project Outputs Marketing

INNOVATION AWARDS

National and Int’l MEDIA COVERAGE

Nations’ s Wealth

Is not by what they have

Or what they know

But

By Knowing what to do

with what they have

Contact Data

• Address: 118 Mohy El Dein Abo El Ezz. Giza POC 12411- EGYPT

• Tel: 00202 33045736

• Fax: 00202 33477755

• Email: dr.amrhelal@healhtech-eg.com

• Web site : www.healthtech-eg.com

Healthtech-eg.com