Post on 16-Dec-2015
Respiratory Failure and Non-Invasive ventilation
Sophie FletcherConsultant Respiratory Physician
Key Learning Points
SpRs• NIV settings• What do the buttons do?• What do you do when it is
not working?
Respiratory Consultants/ ITU• Patient selection• Don’t forget to treat the
patient
Underlying physiology
Overview
• Physiology • NIV settings• BIPAP in practice• What to do when NIV isn’t working• Case studies
Gas transport
Oxygen
• Carried in Hb• pO2 >10kPa -sats 100%
saturatedThen • Exchange dependent on VQ
match
Gas transport
CO2
CO2
CO2
CO2
Carbon Dioxide
• In solution• Exchange dependent capillary/
alveolar partial pressure gradientTherefore
• Exchange is dependent on ventilation (minute volume)
Minute volume = tidal volume x respiratory rate
Terminology of Breathing
• Tidal volume is the amount of air in each breath
• Functional Residual Capacity is the volume that is left in the lungs when we have breathed out from a normal breath
Terminology of CPAP and NIV
• CPAP• BIPAP/ NIPPV• EPAP/ PEEP• IPAP
CPAP• Continuous positive
airways pressure– Same pressure (5-10
cmH2O) throughout respiratory cycle
• Increases intra-alveolar and intra-bronchiolar pressure– Recruits alveoli– Pulmonary oedema– Increase FRC and decreases
tidal volume
5-10cmH2O
BIPAP
• Bi-level Positive Airways Pressure– Lower positive pressure
during expiration (EPAP) (equivalent to CPAP)
– Higher positive airways pressure during inspiration (IPAP)
• CPAP + Increases tidal volume
5-10cmH2O12-20cmH2O
IPAPEPAP
BIPAP
• EPAP (PEEP)
– Recruits alveoli– Increases VQ matching– Improves oxygenation
• IPAP – EPAP (pressure support)
– Increases tidal volume– Reduces CO2
5-10cmH2O
12-20cmH2O
IPAP
EPAP
Putting it into practice
Aims of respiratory support
• Prevent tissue hypoxia• Control acidosis and hypercapnia• Support medical management
– Maximise lung function– Reverse precipitating cause
Respiratory support
• Oxygen therapy• Respiratory stimulants• Non invasive ventilation• Invasive mechanical ventilation
Medical management
• Bronchodilators• Systemic steroids• Antibiotics• Physiotherapy• Mucolytics
pH as a marker of severity
• Not the absolute level of PaCO2• But the magnitude and speed of change, as
reflected in the pH
What’s the evidence?• Warren et al. Lancet 1980; i:467-70.
– Increased mortality with age and worsening acidosis (pH <7.26)
• Jeffrey et al. Thorax 1992; 47:34-40.– Prospective, 139 episodes in 95 patients.– Death in 10/39 when pH<7.26– No difference in hypoxia or hypercapnia
• Plant et al. Thorax 2000; 55:550-4.– 1 yr prevalence study– Mortality with normal pH – 6.9%– Mortality with pH<7.35 – 13.8%
Oxygen therapy
Balancing hypoxia with respiratory acidosis
Achieving the balance
• All hypercapnic patients are at risk of acidaemia with oxygen therapy
• Aim for sats 88-92% (7.3-10 kPa)• Use Venturi mask• Regular monitoring• Use of an oxygen prescription chart
When to consider a respiratory stimulant
• Very rarely• Awaiting NIV to be initiated• NIV not available• NIV poorly tolerated• Reduced respiratory drive
Implementing BIPAP in practice
What underlying conditions?
Resp HDU
• Acute exacerbation COPD (AECOPD)
• Obesity related hypoventilation syndrome (OHS)
• (Neuromuscular disease)
ITU (unless IPPV inappropriate)
• Asthma• Chest wall deformity
• Usual causes of Type 1 respiratory failure– Pneumonia– Cardiac failure– (ILD)
Checklist for starting BIPAP
• Type 2 respiratory failure with acidosis• Medical treatment of underlying condition has
been implemented• Medical treatment and controlled oxygen
therapy has not controlled the acidosis• There is no contraindication to NIV
– Pneumothorax excluded• IPPV is not immediately indicated• NIV is according to the patients wishes
Start with the end in mind
• What are the limits of care?– Is escalation to IPPV appropriate?– Has a decision been made regarding resuscitation?– What are the patient’s wishes and expectations?– What are the patient’s / relatives’ wishes and
expectations?
Starting NIV
• Correct mask size• Experienced nurse
– Outreach– (RespHDU nurses)
• Explain what is going to happen to the patient• Start low
– IPAP 12– EPAP 4
• Stay with the patient
Choosing the settings
• Increase IPAP gradually – Increments of 2 cmH2O
• To decrease CO2
– Increase TV– Increase gap between
IPAP and EPAP
• To increase O2
– Increase EPAP– Increase FiO2
Obesity:• May need
higher pressures
Bullae:• Caution with
high pressures
It is not working
• Patient is deteriorating or getting agitated• CO2 is rising or not responding• Patient remains hypoxic• Patient is not tolerating the NIV
Exclude complications
• Pneumothorax• Retained secretions• Lobar collapse
• (Hypotension)– High pressures– Exclude dehydration
CO2 is not responding
• Mask leak• Patient not synchronising
– Fast respiratory rate• Reassurance and explanation
– Anxiety
• FiO2 is too high• Maybe need to increase IPAP
Hypoxia is not improving
• Increase EPAP• Increase FiO2
Agitated patient
• Reassurance• Check patient comfort
– Mask fit (leak into eyes)– Dry mouth/ nose
• Allow breaks from the machine
• (Anxiolytics)– Haloperidol,
Defining NIV treatment failure
• Patient intolerance / failure to co-ordinate• pH < 7.20 despite optimal support• pH 7.20 – 7.25 on 2 occasions 1 hour apart• Hypercapnic coma (GCS < 8 and PaCO2 > 8 kPa)
• PaO2 < 6.00 kPa despite max tolerated FiO2
• New onset of other initial exclusion criteria, particularly sputum retention, vomiting, or
pneumothorax • Cardiorespiratory arrest
Proceed to mechanical ventilation?What to consider
• Physiology – pH, RR• Severity of underlying disease• Reversibility of precipitating cause• QoL of patient• Co-morbidities• Patient wishes
Stopping NIV
• Not a death sentence• Can use opiates for distress• Controlled oxygen therapy
Audience participation
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough,
sputum production and dyspnoea
Time Baseline
Oxygen 40 % facemask
GCS 13
PaO2 kPa 15.0
PaCO2 kPa 8.53
pH 7.27
H+ nmol/l 53
HCO3- mmol/l 24
SaO2 % 99
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough, sputum production and dyspnoea
- control FiO2
Time Baseline 30 mins
Oxygen 40% facemask 24% f/mask
GCS 13 15
PaO2 kPa 15.0 9.7
PaCO2 kPa 8.53 6.8
pH 7.27 7.34
H+ nmol/l 53 46
HCO3- mmol/l 24 26
SaO2 % 99 95
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough, sputum production and dyspnoea
Time Baseline
Oxygen 24 % facemask
GCS 15
PaO2 kPa 7.43
PaCO2 kPa 10.35
pH 7.34
H+ nmol/l 46
HCO3- mmol/l 39
SaO2 % 87
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough, sputum production and dyspnoea
- standard therapy
Time Baseline 1 hour
Oxygen 24 % f/mask 24 % f/mask
GCS 15 15
PaO2 kPa 7.43 7.62
PaCO2 kPa 10.35 9.63
pH 7.34 7.36
H+ nmol/l 46 44
HCO3- mmol/l 39 39
SaO2 % 87 89
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough, sputum production and dyspnoea
- standard therapy….failure
Time Baseline 1 hour
Oxygen 24% f/mask 24% f/mask
GCS 15 13
PaO2 kPa 7.43 6.35
PaCO2 kPa 10.35 12.48
pH 7.34 7.29
H+ nmol/l 46 51
HCO3- mmol/l 39 36
SaO2 % 87 81
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough, sputum production and dyspnoea
- NIV - good response
Time Baseline 1 hour 2 hours
Oxygen 24% f/mask 24% f/mask NIV 15/5 + 3l/min
GCS 15 13 15
PaO2 kPa 7.43 6.35 7.3
PaCO2 kPa 10.35 12.48 9.94
pH 7.34 7.29 7.35
H+ nmol/l 46 51 45
HCO3- mmol/l 39 36 38
SaO2 % 87 81 86
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough, sputum production and dyspnoea
- NIV - hypoxaemia
Time Baseline 1 hour 2 hours
Oxygen 24% f/mask 24% f/mask NIV 15/5 + 3l/min
GCS 15 13 15
PaO2 kPa 7.43 6.35 6.28
PaCO2 kPa 10.35 12.48 10.57
pH 7.34 7.29 7.33
H+ nmol/l 46 51 47
HCO3- mmol/l 39 36 38
SaO2 % 87 81 79
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough, sputum production and dyspnoea
- NIPPV - hypoxaemia - increase O2
Time Baseline 1 hour 2 hours 2.5 hours
Oxygen 24% f/mask
24% f/mask
NIV 15/5 + 3l/min
NIV 15/5 + 6 l/min
GCS 15 13 15 15
PaO2 7.43 6.35 6.28 7.39
PaCO2 10.35 12.48 10.57 10.21
pH 7.34 7.29 7.33 7.35
H+ 46 51 47 45
HCO3- 39 36 38 38
SaO2 87 81 79 85
78 y.o. woman, known COPD, IHD, DM, AF, multiple admissions, smokes 5/day, home nebs, LTOT,
housebound - increased cough, sputum, leg oedema over 48 hrs, confused at home
Time Baseline
Oxygen 15L and non rebreathe
GCS 5
PaO2 kPa 14.29
PaCO2 kPa 15.34
pH 7.06
H+ nmol/l 87
HCO3- mmol/l 34
SaO2 % 98
78 y.o. woman, known COPD, IHD, DM, AF, multiple admissions, smokes 5/day, home nebs, LTOT, housebound - increased cough,
sputum, leg oedema over 48 hrs, confused at home - control FiO2
Time Baseline 30 mins
Oxygen 15L 24% f/mask
GCS 8 10
PaO2 kPa 14.29 6.13
PaCO2 kPa 15.34 13.98
pH 7.06 7.12
H+ nmol/l 87 76
HCO3- mmol/l 34 34
SaO2 % 98 78
78 y.o. woman, known COPD, IHD, DM, AF, multiple admissions, smokes 5/day, home nebs, LTOT, housebound - increased cough,
sputum, leg oedema over 48 hrs, confused at home - control FiO2
Time 30 mins 1 hour 2 hours
Oxygen 24% f/mask 24% f/mask 24% f/mask GCS 10 13 12 PaO2 6.13 6.40 6.22 PaCO2 13.98 13.27 13.02 pH 7.12 7.21 7.23 H+ 76 62 59 HCO3- 34 34 35 SaO2 78 82 80
78 y.o. woman, known COPD, IHD, DM, AF, multiple admissions, smokes 5/day, home nebs, LTOT, housebound - increased cough, sputum, leg oedema over 48 hrs, confused at home NIV - good
response
Time 30 mins 1 hour 2 hours 3 hours
Oxygen 24% f/mask
24% f/mask
24% f/mask
NIV 14/4 + 3 l/min
GCS 10 13 12 14
PaO2 6.13 6.40 6.22 7.54
PaCO2 13.98 13.27 13.02 11.87
pH 7.12 7.21 7.23 7.31
H+ 76 62 59 49
HCO3- 34 34 35 36
SaO2 78 82 80 92
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough, sputum production and dyspnoea
- NIV - persistent hypercapnia
Time Baseline 1 hour 2 hours
Oxygen 24% f/mask 24% f/mask NIV 15/5 + 3l/min
GCS 15 13 13
PaO2 kPa 7.43 6.35 6.85
PaCO2 kPa 10.35 12.48 12.29
pH 7.34 7.29 7.30
H+ nmol/l 46 51 50
HCO3- mmol/l 39 36 36
SaO2 % 87 81 82
68 y.o. man, known COPD, current smoker 20/day, inhaled therapy only - presents following 2 weeks of increased cough,
sputum production and dyspnoea- NIV - hypercapnia - increased IPAP
Time Baseline 1 hour 2 hours 2.5 hours
Oxygen 24% f/mask
24% f/mask
NIV 15/5 + 3 l/min
NIV 20/6 + 3 l/min
GCS 15 13 13 15
PaO2 7.43 6.35 6.85 7.42
PaCO2 10.35 12.48 12.29 9.87
pH 7.34 7.29 7.30 7.35
H+ 46 51 50 45
HCO3- 39 36 36 38
SaO2 87 81 82 86
Learning Points
• Hypercapnia ≠ BIPAP• Start with the end in mind• Diagnose and treat the underlying problem• Coach the patient