RENAL PATHOLOGY

SLIDE PRESENTATIONBy

Dr.ASMAA NAJIM

HORSE-SHOE KIDNEY

PELIVIC KIDNEY –RIGHT SIDE

INTRAVENOUS PYLOGRAM (Pelvic right kidney)

Here is a much larger simple renal cyst of the upper pole. Other smaller cysts are also scattered around the kidney. The ureter exits south on the left. Such a large renal cyst would be seen on a radiographic imaging procedure, but could probably be distinguished from a neoplasm by its fluid density.

ADULT congenitalpolycyctic kidney disease

ADPKD

The cut surfaces of these kidneys in a patient with ADPKD reveal that the parenchyma is replaced by large cysts. Note how large these kidneys are in relation to the normal sized transplanted kidney.

Autosomal Recessive polysystic kidney disease

ARPKD

SCHEME : showing hydronephrosis and hydroureter

HYDRONEPHROSIS OF THE KIDNEY

The arrow points to the culprit in this case of hydronephrosis--a ureteral calculus at the ureteropelvic junction. This kidney demonstrates marked hydronephrosis with nearly complete loss of cortex.

Both lymphocytes and plasma cells are seen at high magnification in this case of chronic pyelonephritis. It is not uncommon to see lymphocytes accompany just about any chronic renal disease: glomerulonephritis, nephrosclerosis, pyelonephritis. However, the plasma cells are most characteristic for chronic pyelonephritis.

The end of part 1

RENAL CELL CARCINOMA

Cystic change resulting from long-term renal dialysis may rarely give rise to renal cell carcinoma. A large variegated mass is seen here on sectioning of a kidney that has large cysts arranged around the mass.

CLEAR CELL CARCINOMA

This small kidney from a 4 year old child contains a lobulated tan-white mass. This is Wilm's tumor of the kidney. Many are now known to be associated with genetic defects on chromosome 11. The children with Wilm's tumor usually present with abdominal enlargement from the mass effect. Nowadays, treatment gives a better than 90% 5 year survival.

This is a Wilm's tumor that is composed microscopically of nests and sheets of dark blue cells at the left with compressed normal renal parenchyma at the right.

Normal stratified transitional epithelium of the urinary bladder

Keratinized stratified squamus cell epithelium

Papilloma

Papilloma

Transitional cell carcinoma of urinary bladder

At high power, the transitional cell carcinoma does resemble urothelium, but the thickness is much greater than normal and the cells show more pleomorphism.

transitional cell carcinoma (papillary varient-low grade)

Transitional cell carcinoma –transverse sectin –low grade

tumor

Transitional cell carcinoma –papillary varient – higher grade

Vascular invasion –transitional cell carcinoma

Transitional cell carcinoma –solid pattern –high grade

Squmous cell carcinoma of urinary bladder (schistosomiasis)