RB biochemistry - Center for Cancer ResearchRedox Biology: Biochemistry David A. Wink and Murali C....

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Transcript of RB biochemistry - Center for Cancer ResearchRedox Biology: Biochemistry David A. Wink and Murali C....

RB biochemistry

Biochemistry Summary

Formation and Abatement of Oxidants

Oxygen Reduction

Redox Cycling

Menadione and Dopamine

Pro-Oxidant vs Antioxidant

Vitamins Working in Concert

Xenobiotic Metabolism

Mitochondrial Sources of ROS

Energetics of ROS Formation

Inner-Sphere Reduction Examples

P450 System

Enzymatic Generation Purpose

Hydrogen Peroxide Formation Example

Xanthine Oxidase

Xanthine Oxidase

NADPH Oxidase

NADPH Oxidase

Nitric Oxide Synthase

Nitric Oxide Synthase

NOS Biochemistry

Heme Oxygenase

Biochemistry of Prevention

Biochemistry Reactive Oxygen Species

Preventive Mechanisms

Chemical Biology of Nitric Oxide

Scavenging of NO

Glutathione Peroxidase Biochemistry

Peroxiredoxin

Seleno-Cysteine Reduction

Glutathione Metabolism

Abatement of Nitrosative Stress

Glutathione and Ascorbate Pools

Urate and Uric Acid

Interaction of NO and ROS

Oxygen and NAPDH Essential