Post on 19-Jan-2016
description
Formal total synthesis of (-)-balanol: a potent PKC inhibitor. Yaragorla, Srinivasarao; Muthyala, Ramaiah. Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA. Tetrahedron Letters (2010), 51(3), 467-470.
Pyridinium dichromate (PDC) is a commercially available (and also readily prepared) salt of chromic acid that is soluble in many common organic solvents and useful in the oxidation of alcohols to aldehydes and ketones. It is less acidic than pyridinium chlorochromate (PCC), and thus more suitable for the oxidation of acid-sensitive substrates.
Pyridinium Dichromate (PDC): The Corey-Schmidt Reagent
Pyridinium Chlorochromate (PCC)
Corey-Suggs Reagent
Elias J. CoreyProfessor Emeritus, Harvard University
Nobel Prize Winner:
Shi Epoxidation
Oxone = Potassium Peroxymonosulfate =
Mechanism of the Shi Epoxidation
Chiral Dioxirane
Yian Shi Colorado State University
The chiral catalyst of the Shi Epoxidation is derived from the readily-available D-Fructose
Chiral Ketone Catalyst
Dimethyldioxirane(DMDO)
Trost Asymmetric Allylic Alkylation Reaction
Palladium -allyl complex
Barry TrostStanford University
Methods for Reduction of Azides to Amines