Prof.FedericoBordi

DeptofPhysics

current research activities in

applied physics : a brief outline

FedericoBordi federico.bordi@uniroma1.itfederico.bordi@roma1.infn.it

5/24/16 Research in applied physics Pagina 101

A long history made short the natural heir of the tradition of the Institute of Physics where P. Blaserna, the first president of the Italian Physical Society, was appointed director in 1872 and in 1926 Enrico Fermi was called to hold the first Chair of Theoretical Physics

5/24/16 Research in applied physics Pagina 102

A long history made short the natural heir of the tradition of the Institute of Physics, where P. Blaserna, the first president of the Italian Physical Society, was appointed director in 1872 and in 1926 Enrico Fermi was called to hold the first Chair of Theoretical Physics

Today ... an intense research activity in all the major areas of Physics: Particle Physics, Physics of Matter, Astrophysics and

Cosmology, Theoretical Physics, Biophysics, Geophysics Mathematical and Statistical Physics,

and applied Physics : to Cultural Heritage, Medicine, Biotechnology, Material Science and Nanotechnology

hos.ngresearchfacili.esofthemajorItalianresearchins.tu.ons,theNa.onalIns.tuteofNuclearPhysics(INFN)andtheConsiglioNazionaledelleRicerche(CNR),appoximately300researchersareac+veinourdepartment,includingtheprofessorsattheSapienzaUniversity.

Grapheneflakesaspoten+al

electrodesforLi-basedba]eries

adsorbmuchmoreLithiumions(Li:C=1:2)thangraphite

(Li:C=1:6)Graphenesingle-sheetasdecouplinglayer

inducingincreasedmagne+canisotropyofanorganometallicmolecule(FePc)

J. Phys. Chem. Letters 6, 1690 (2015)

...justafewexamples

Nano Letters 14, 4901 (2014)

Nano-porousgraphene,a3Dformofgrapheneforchargeaccumula+on

Graphene-based materials for energy and technology

LOTUS lab. (interfaces and nanostructures) MariaGraziaBETTIandCarloMARIANI

hVp://server2.phys.uniroma1.it/gr/lotus/index.htm

5/24/16 Research in applied physics Pagina 104

... just a few examples

Radio-guided surgery with β-radiation

Applied Radiation Physics (ARP) Group RiccardoFACCINI

hVp://arpg-serv.ing2.uniroma1.it/arpg-site/

usuallylongrangeγ-emi]erareused->(140keV photon: 8 cm in tissues)

• Exposureofmedicalpersonnel• Backgroundfromsurrounding

(healthy)+ssues

5/24/16 Research in applied physics Pagina 105

... just a few examples

Radio-guided surgery with β-radiation

Applied Radiation Physics (ARP) Group RiccardoFACCINI

hVp://arpg-serv.ing2.uniroma1.it/arpg-site/

usingshortrangeβ-tracer->(1 MeV photon: 5 mm in tissues)

• Reduceddosetomedicalstaff• Reducedbackground• Smalleradministeredac<vity• moreCompactdetectorsSCIENTIFIC REPORTS 4, 4401 (2014)

5/24/16 Research in applied physics Pagina 106

... just a few examples

Radio-guided surgery with β-radiation

Applied Radiation Physics (ARP) Group RiccardoFACCINI

hVp://arpg-serv.ing2.uniroma1.it/arpg-site/

usingshortrangeβ-tracer->(1 MeV photon: 5 mm in tissues)

SCIENTIFIC REPORTS 4, 4401 (2014)

scin.lla.ngcrystal+lightsensor(SiPM)

...justafewexamples

Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics

PhOBiA lab. (Physics of Bio-Assemblies) FedericoBORDIandPaoloPOSTORINO

hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html

acurrentchallengeinearlycancerdiagnosisisthecapabilityofrevealingthepresenceoffewcancercellsonsmallbiologicalsamples

...justafewexamples

Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics

PhOBiA lab. (Physics of Bio-Assemblies) FedericoBORDIandPaoloPOSTORINO

hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html

acurrentchallengeinearlycancerdiagnosisisthecapabilityofrevealingthepresenceoffewcancercellsonsmallbiologicalsamples

SERSeffectbasedonthelocalizedplasmonresonanceinmetallicnanostructuresincreasestheintensityofRamanemissionofmoleculesclosetothenanopar+clesurfacebyseveralordersofmagnitude

...justafewexamples

Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics

PhOBiA lab. (Physics of Bio-Assemblies) FedericoBORDIandPaoloPOSTORINO

hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html

acurrentchallengeinearlycancerdiagnosisisthecapabilityofrevealingthepresenceoffewcancercellsonsmallbiologicalsamples

goldnano-par+cles(AuNp)conjugatedwithfolicacid(FA)areusedtoSERS-revealFAreceptorsthatareover-expressedbytherapidlydividingcancercells(FAisrequiredinDNAsynthesisprocess)

...justafewexamples

Surface Enhanced Raman Spectroscopy (SERS) for single cell diagnostics

PhOBiA lab. (Physics of Bio-Assemblies) FedericoBORDIandPaoloPOSTORINO

hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html

acurrentchallengeinearlycancerdiagnosisisthecapabilityofrevealingthepresenceoffewcancercellsonsmallbiologicalsamples

healthyandcancercellscanbedis+nguishedbyusingthe(substratenormalized)integratedintensityofthenanovector-specificSERSband(1580cm-1),basedonthedifferentexpressionofFOLICACIDreceptors

BIOMATERIALS2016,submiVed

...justafewexamples

Complex NANO-particles for theranostics

PhOBiA lab. (Physics of Bio-Assemblies) FabioDOMENICI,GaioPARADOSSIandFedericoBORDI

hVp://server2.phys.uniroma1.it/gr/PhOBiA/index.html

selec+velytargetedthermoresponsivenanogels:atemperaturedrivenshrinkingreleasesthedrugcargo(DOXORUBICIN)

Biomacromolecules16,1753(2015) Phys.Chem.Chem.Phys.18,8378(2016)

doubleshelled(lipidandcrosslinkedpolymer)decafluoropentane(DFP)dropletsforenhancedultrasoundcontrast

...andmuchmore

NMR diffusion of water for diagnostics

NMR lab SilviaCAPUANIhVp://lab-g1.phys.uniroma1.it/

molecular dynamics of proteins

AlexanderTENENBAUMalexander.tenenbaum@roma1.infn.it

...manyac+vi+es

my contacts

FedericoBORDIfederico.bordi@uniroma1.itfederico.bordi@roma1.infn.it

PlainP

VAMBs

G/PVA

MBs

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