THERAPY SOLO CAT

HAMAD emad thuhayr

CONTENT

• WHAT QUESTION DID THE STUDY ASK?

• ARE THE RESULTS OF THE STUDY VALID (STEP 1)

• WHAT WERE THE RESULTS (STEP 2)

• APPLICABILITY OF THE RESULTS ( STEP 3)

WHAT QUESTION DID THE STUDY ASK?

CATEGORY ANSWER

POPULATION Children ( 2-6 years) with respiratory illnesses

INTERVENTION Using normal milk containing probiotic lactobacillus rhamnosus GG

COMPARISON Normal milk only

OUTCOME Primary : measure the respiratory symptoms improvement by using probiotic GG milk

Secondary: measure the gastrointestinal symptoms improvement by using probiotic GG milk

ARE THE RESULTS OF THE STUDY VALID

Was the assignment of patients to treatment randomized?

ARE THE RESULTS OF THE STUDY VALID

Was the randomization list concealed?

ARE THE RESULTS OF THE STUDY VALID

Was follow-up of patients sufficiently long and complete?

ARE THE RESULTS OF THE STUDY VALID

Were patients analyzed in the groups which they were randomized?

ARE THE RESULTS OF THE STUDY VALID

Were patients and clinician kept ‘blind’ to treatment?

yes, blinding both the clinician and children *parent* to the treatment.

ARE THE RESULTS OF THE STUDY VALID

Were the groups treated equally, apart from the experimental treatment?

ARE THE RESULTS OF THE STUDY VALID

Were the groups similar at the start of the trial?

ARE THE VALID RESULTS OF THIS RCT IMPORTANT?

What is the magnitude of the treatment effect?

Odd Ratio REGARDING TO PRIMARY OUTCOME ( RESPIRATORY SYMPTOMS )

GG group

OR of 5.03(95% CI 4.92-5.15 )

Placebo group OR of 5.17(95% CI 5.05-5.29)

ARE THE VALID RESULTS OF THIS RCT IMPORTANT?

How precise is this estimate of the treatment effect?

Odd Ratio REGARDING TO PRIMARY OUTCOME ( RESPIRATORY SYMPTOMS )

GG group

OR of 5.03(95% CI 4.92-5.15 )

Significant and precise

Placebo group OR of 5.17(95% CI 5.05-5.29)

Significant and precise

ARE THESE VALID, IMPORTANT RESULTS

APPLICABLE TO MY PATIENTS?

Is our patient so different from those in the study that its results cannot apply ?The patients in the study are similar to our patients, mainly similar Demographic and clinical characteristics ( which the author provides)

So, we can apply the results in our setting

Is the treatment feasible in my setting ?

Milk containing probiotic Lactobacillus rhamnosus GG is available in our market

0000000

ARE THESE VALID, IMPORTANT RESULTS

APPLICABLE TO MY PATIENTS?

What are our patient’s potential benefits and harms form the therapy ?

Benefits

0

Harms

0

ARE THESE VALID, IMPORTANT RESULTS

APPLICABLE TO MY PATIENTS?

What are our patients values and expectations for both the outcome we are trying to prevent and the treatment that we are offering ?

Decrease respiratory symptoms as a primary outcome of the study, also decrease gastrointestinal symptoms

Find an alternative method to decrease the illness with effectively with less side effects and easy administration not like the chemical drugs

ARE THESE VALID, IMPORTANT RESULTS

APPLICABLE TO MY PATIENTS?