Transcript of Preventative and Therapeutic Treatment of Resveratrol on Alzheimer’s Disease using CL2006 and...
- Slide 1
- Preventative and Therapeutic Treatment of Resveratrol on
Alzheimers Disease using CL2006 and CL4176 C. elegan models
Bradford Greaves
- Slide 2
- Need
http://www.searo.who.int/en/Section1174/Section1199/Section1567/Section1823_8066.htm
- Slide 3
- The APP Processing Senile Plaques Modified from Laurn et al.,
Nature (2009) Figure 1 Resveratrol Promotes Clearance of Alzheimers
Disease Amyloid- Peptides, Marambaud 2005 The amyloid peptide can
act as a modular aggregation domain, Link 2008
- Slide 4
- Alzheimers Disease cont.
http://www.nia.nih.gov/NR/rdonlyres/A294D332-71A2-4866-BDD7-A0DF216DAAA4/0/Alzheimers_Disease_Unraveling_the_Mystery.pdf
- Slide 5
- Oxidative Damage
http://www.nia.nih.gov/NR/rdonlyres/A294D332-71A2-4866-BDD7-A0DF216DAAA4/0/Alzheimers_Disease_Unraveling_the_Mystery.pdf
- Slide 6
- Purpose To preventatively and therapeutically treat Alzheimers
Disease with resveratrol using CL2006 and CL4176 C. elegan
models
- Slide 7
- Hypothesis Alternate Hypothesis: Both preventive and
therapeutic treatment of resveratrol on CL2006 will lead to a
decrease in amyloid beta production and for CL4176 there will be a
delay of the onset of paralysis. Null Hypothesis: There will be no
change in amyloid beta production nor paralysis with the addition
of resveratrol.
- Slide 8
- Resveratrols Coloration With Alzheimers Disease
http://www.chiro.org/nutrition/ABSTRACTS/Resveratrol_in_Prevention_and_Treatment.pdf
- Slide 9
- Figure 2 Soy isoflavone glycitein protects against beta
amyloid-induced toxicity and oxidative stress in transgenic
Caenorhabditis elegans, Gutierrez-Zepeda 2005 Transgenic C. elegans
as a Model in Alzheimers Research, Wu 2005
- Slide 10
- Slide 11
- Slide 12
- Do Ability CL2006 and CL4176: Staining and Paralysis Control
food and Resveratrol available Fluorescent Microscope at
school
- Slide 13 . Duchen, Michael R. "Roles of Mitochondria in Health
and Disease." Whereas some of the genes identified in the control
of longevity appear to target mitochondria or at least to alter
antioxidant defenses of the cell (Duchen, 2004. 2004. Diabetes. 7
May 2009. Halliwell, Barry, and John M.C. Gutteridge. Free Radicals
in Biology and Medicine. 3rd ed. New York: Oxford UP, 2004.
Lagouge, Marie, Carmen Argmann, Zachary Gerhart-Hines, Hamid
Meziane, Carles Lerin, Frederic Daussin, Nadia Messadeq, Jill
Milne, Philip Lambert, Peter Elliott, Bernard Geny, Markku Laakso,
Pere Puigserver, and Johan Auwerx. "Resveratrol Improves
Mitochondrial Function and Protects Against Metabolic Disease by
Activating SIRT1 and PGC-1a." Cell (2006). 20 May 2008. Lenker,
David P. Professional Guide to Diseases. 8th ed. New York: Williams
& Wilkins., 2005 Marambaud, Phillipe. Wine Compound May Help
Cut Risk of Alzheimers Disease. 16 Nov. 2005. 24 Apr.
2009.http://www.sciencedaily.com/releases/2008/06/080617165716.htm>.
McKenzie, Maureen A. "Insulin Receptor-Like Protein." Patent Storm.
5 Oct. 1992. 18 Apr. 2008. O,Neill, Bill. "In Methuselahs Mould."
Feature 2 (2004): 0014-017. PLoS
Biology..http://www.culturagalega.org/imaxes/docs/plos_lonxevidade.pdf>.
"Resveratrol Studies Suggest Broad Implications for SIRT1
Activation,in Neurodegenerative Diseases of Aging Such as
Alzheimer's Disease ( whether any of the Company's product ca...)."
Bio-Medicine - latest biology and medical news/technology. 26 June
2007. 29 Apr. 2009. Rogers, Kara, ed. "Alzheimer's Disease."
Encyclopdia Britannica. 15th ed. 2002. 306-07. Society for
Neuroscience. "Grape Seed Extract May Reduce Cognitive Decline
Associated With Alzheimer's Disease." ScienceDaily 18 June 2008. 29
April 2009.">
- Bibliography Bundschuh, K. "The worm in humans." 11 Nov. 2008.
Biotechnology and Life Sciences in Baden-Wrttemberg. 6 May 2009.
Cheng, Louse. Compound in Red Wine May Fight Alzeimers. WebMD. 4
Nov. 2005. 15 Apr.
2009.http://www.webmd.com/alzheimers/news/20051104/compound-in-red-wine-may-fight-alzheimer>.
Duchen, Michael R. "Roles of Mitochondria in Health and Disease."
Whereas some of the genes identified in the control of longevity
appear to target mitochondria or at least to alter antioxidant
defenses of the cell (Duchen, 2004. 2004. Diabetes. 7 May 2009.
Halliwell, Barry, and John M.C. Gutteridge. Free Radicals in
Biology and Medicine. 3rd ed. New York: Oxford UP, 2004. Lagouge,
Marie, Carmen Argmann, Zachary Gerhart-Hines, Hamid Meziane, Carles
Lerin, Frederic Daussin, Nadia Messadeq, Jill Milne, Philip
Lambert, Peter Elliott, Bernard Geny, Markku Laakso, Pere
Puigserver, and Johan Auwerx. "Resveratrol Improves Mitochondrial
Function and Protects Against Metabolic Disease by Activating SIRT1
and PGC-1a." Cell (2006). 20 May 2008. Lenker, David P.
Professional Guide to Diseases. 8th ed. New York: Williams &
Wilkins., 2005 Marambaud, Phillipe. Wine Compound May Help Cut Risk
of Alzheimers Disease. 16 Nov. 2005. 24 Apr.
2009.http://www.sciencedaily.com/releases/2008/06/080617165716.htm>.
McKenzie, Maureen A. "Insulin Receptor-Like Protein." Patent Storm.
5 Oct. 1992. 18 Apr. 2008. O,Neill, Bill. "In Methuselahs Mould."
Feature 2 (2004): 0014-017. PLoS
Biology..http://www.culturagalega.org/imaxes/docs/plos_lonxevidade.pdf>.
"Resveratrol Studies Suggest Broad Implications for SIRT1
Activation,in Neurodegenerative Diseases of Aging Such as
Alzheimer's Disease ( whether any of the Company's product ca...)."
Bio-Medicine - latest biology and medical news/technology. 26 June
2007. 29 Apr. 2009. Rogers, Kara, ed. "Alzheimer's Disease."
Encyclopdia Britannica. 15th ed. 2002. 306-07. Society for
Neuroscience. "Grape Seed Extract May Reduce Cognitive Decline
Associated With Alzheimer's Disease." ScienceDaily 18 June 2008. 29
April 2009.