H2O2 + Fe2+ → ˙OH + OH− + Fe3+

New Insight into the Role of Reactive Oxygen Species (ROS) in Cellular Signal-Transduction Processes Int. Rev Cell Mol 2015;319:221-54

Signal transduction by reactive oxygen species. J. Cell Biol. 2011;194: 7–15

Mitochondrial DNA damage and reactive oxygen species inneurodegenerative diseaseFEBS Lett. 2018 Mar;592(5):728-742

ROS Are GoodTrends in Plant Science, 2017, Vol. 22, No. 1

Oxidative Medicine and Cellular Longevity 2016, Article ID 5276130,

Oxidative stress and microRNAsin vascular diseases.Int J Mol Sci. 2013 Aug22;14(9):17319-46

Special issue on oxidative stress in health and disease.Cell Biochem Biophys. 2013 Nov;67(2):215-8

Reactive Oxygen Species in Metabolicand Inflammatory Signaling.Circ Res. 2018 Mar 16;122(6):877-902

Finché la produzione di ROS è bassa l’effetto è benefico in quanto agiscono da molecole segnalatrici

Archives of Biochemistry and BiophysicsVolume 595, 1 April 2016, Pages 33–39

Generation and propagation of radical reactions on proteinsBBA – Bioenergetics . 2001, 1504; 196-219,

Perossidi, idroperossidi,Dimeri, aggregati di proteine

Perossidazionelipidica

Danni al DNA

Free radicals, natural antioxidants, and their reaction mechanismsRSC Adv., 2015, 5, 27986

Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence. Free Radic BiolMed. 2014; 66:3-12.

Catechine e antocianine

oleuropeina

SF protects against the incidence and progression of cancer via several mechanisms including inhibiting phase I cytochrome P450 enzymes, inducing cell-cycle arrest and apoptosis, reducing inflammation, and, modulating the nuclear factor-erythroid-2- related factor 2/Kelch-like ECH-associated protein 1 pathway

BROCCOLI

Glucosinolates from pak choi and broccoli induce enzymes and inhibitinflammation and colon cancer differently. Food Funct. 2014 Jun;5(6):1073-81

Omega 3 fatty acids in cardiovascular disease risk factors: An updated systematic review of randomisedclinical trials. Clin Nutr. 2018 Feb;37(1):72-77.

Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem Soc Trans. 2017 Oct 15;45(5):1105-1115

Omega-3 fatty acids in obesity and metabolicsyndrome: a mechanistic update. J Nutr Biochem. 2018 Feb 27;58:1-1

Resveratrol mitigates lipopolysaccharide-mediated acute inflammationin rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascadeScientific Reports 2017, 7; Article number: 45006

Benefit of Oleuropein Aglycone for Alzheimer's Disease by Promoting Autophagy. Oxid Med Cell Longev. 2018 Feb20;2018:5010741

Potential Therapeutic Effects of Oleuropein Aglycone in Alzheimer's Disease.Curr Pharm Biotechnol. 2016;17(11):994-1001

Oleuropein improves insulin resistance in skeletal muscleby promoting the translocation of GLUT4. J Clin BiochemNutr. 2017 Nov;61(3):196-202

Anticancer effects of oleuropein.Biofactors. 2017 Jul 8;43(4):517-528

Novel antioxidant and anti‐inflammatorypeptides from the Siamese crocodile(Crocodylus siamensis) hemoglobin hydrolysateBiotechnol Appl Biochem. 2017

Antioxidant and Anti-Inflammatory Activities of Hydrolysates and Peptide Fractions Obtained by Enzymatic Hydrolysis of Selected Heat-Treated Edible Insects. Nutrients 2017 9: 970

Antioxidant and anti-inflammatorypeptide fractionfrom salmon by product proteinhydrolysates by peptic hydrolysis. Food ResearchInternational, 2012. 49(1):92–98

Egg and Soy-Derived Peptides and Hydrolysates: A Review of Their Physiological Actions against Diabetes and Obesity.Nutrients. 2018 Apr 28;10(5)

Anticancer Activity of BacterialProteins and Peptides. Pharmaceutics. 2018 Apr 30;10(2)

Peptide based therapeutics and their use for the treatment of neurodegenerative and otherdiseases.Biomed Pharmacother. 2018 Apr17;103:574-581

Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies.Nutrients. 2018 Mar 24;10(4).

Bioactive peptides from selectedlatin american food crops - A nutraceutical and molecularapproach.Crit Rev Food Sci Nutr. 2018 Feb1:1-27.

Assessment of multifunctional activity of bioactive peptides derived from fermented milk by specific Lactobacillus plantarum strains. J. Dairy Sci. 2017 Jan;100(1):65-75

New potentially antihypertensive peptides liberated in milkduring fermentation with selected lactic acid bacteria and kombucha cultures.J Dairy Sci. 2017 Dec;100(12):9508-9520

Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review. Food Chem. 2018; 245:205-222 Production and Functionality of Food-derived bioactive peptides: A review.Mini Rev Med Chem. 2018 Apr 23

SourdoughMix of water and flour fermented bylactobacilli and yeast

Backslopping methodUse of the ”mother dough” to start a newfermentation with fresh water and flour

Better tasteBetter nutritional propertiesLonger shelf life

Idrolisi di glutenine e gliadine

Riduzione del contenuto di glutine

Formazione di prodotti secondari

Formazione di peptidi

Sequenza dei principali peptidi