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PM265

The epidemiological profile of first-ever hospitalisations for atrial fibrillation inAboriginal and non-Aboriginal Western Australians, 2000-2009

Judith M. Katzenellenbogen*1, Tiew-Hwa Katherine Teng1, Derrick Lopez1, Frank Sanfilippo2,Matthew Knuiman2, Michael Hobbs2, Joseph Hung3, Sandra C. Thompson11Combined Universities Centre for Rural Health, 2School of Population Health, 3Sir CharlesGairdner Hospital Unit, The University of Western Australia, Perth, Australia

Introduction: The epidemiology of atrial fibrillation (AF) is poorly described forAboriginal Australians, despite AF being a major determinant of heart failure andstroke.Objectives: To compare the epidemiological profile of first-ever hospitalised AF betweenAboriginal and non-Aboriginal Western Australians aged 20-84 years (2000-09) withrespect to incidence, demography, co-morbidity, 28-day and 1-year mortality.Methods: Incident public and private hospital AF admissions (AF hospital admission-freefor 15 years) were identified from all diagnosis fields, and subsequent mortality deter-mined using person-based linked hospital and mortality data. Comorbidity histories ofspecific chronic conditions were ascertained using a 10-year look-back from index AFadmission. Age-standardised incidence rates were estimated using the WHO standard andthe adjusted risk of 28-day and 1-year mortality calculated using logistic and Coxregression.Results: Aboriginal patients comprised 923 (2.5%) of the 37,097 incident AFs. Comparedwith non-Aboriginal patients, Aboriginal patients had lower proportions of AF diagnoses inthe primary diagnosis field (24% vs 33%) but higher emergency presentations (85% vs65%); lower mean age (54.8 vs 69.3 years); more females (45.9% vs 40.8%) and ruraladmissions (50% vs 14%); higher comorbidity prevalence of heart failure, diabetes andCKD (all p<¼0.001). Age-specific AF incidence rates were higher in Aboriginals than non-Aboriginal in all age groups <70 years. The Aboriginal to non-Aboriginal age-standardisedAF incidence rate ratios for men and women 20-54 years were 3.6 and 6.4 respectively and1.3 and 1.8 respectively for 55-84 years.Crude and adjusted 28-day mortality was similar in both groups. Crude 1-year mortality

in 28-day survivors with a primary AF diagnosis was significantly higher in Aboriginalpatients (7.5% vs 3.5%), while fully adjusted mortality was significantly higher inAboriginal women (HR¼1.7: CI 1.23-2.34) but not men (HR¼1.28: CI 0.93-1.76). Theadjusted HR for 1-year mortality in Aboriginal patients with a secondary AF diagnosis was1.30 (CI 1.02-1.65).Conclusion: The incidence of hospitalised AF is significantly higher in Aboriginal people,particularly at younger ages. The high proportion being admitted with AF as a secondarydiagnosis and as an emergency suggests that AF is under-diagnosed and undertreated inthis population. The higher 1-year mortality implies the need for better post-dischargemanagement.Disclosure of Interest: None Declared

PM266

Predicting 30-years cardiovascular disease in riverside communities in the BrazilianAmazon

Raitany C. Almeida*1, Otavio R. Coelho2, Diego J. Dias1, Carlos H. Spesia1, Karime Deguchi1,Victor H. Motta JR1, Vinicius R. Grillo3, Manoel G. Souza Neto1, Marcella S. Martello11Universidade Federal Rondonia, Porto Velho, 2UNICAMP, Campinas, 3LIGA Rondoniense deCardiologia, Porto Velho, Brazil

Introduction: Cardiovascular diseases (CVD) remain the leading cause of mortality inBrazil and worldwide. Estimate CVD risk in the next 30 years tends to improve the primaryprevention.Objectives: To determine the risk of developing CVD in the next 30 years in riversidecommunities in the Brazilian Amazon and to evaluate the percentage of the populationabove normal risk comparing gender and age.Methods: Between April and July 2013, household visits was conducted in four riversidethe communities at Madeira River – Amazon. The study was cross-sectional, descriptive,quantitative and qualitative. Standardized questionnaires were used, measured bloodpressure (BP), weight, height, waist circumference. The 30-years CVD risk was observed inpatients aged 20 to 59 years and assessed the following predictors: gender, age, systolicblood pressure, smoking, use of antihypertensive drugs, body mass index and diabetes. Therisk of developing CVD in 30 years was calculated based on the Framingham risk score andall the data analyzed in the statistical program Epiinfo.Results: Included 637 subjects, 44.58% were male (M). The median age was 37.62 years(SD: + / -13.38). Of female (F) subjects between 20-29 years, 45.53% were above normalrisk for 30 years -CVD, while 65.21% male (p <0,05). Between 30 to 39 years had56.55%(F) vs. 73.61%(M)( p <0.05). Between 40-49 years had 85.33%(F) vs. 81.81% (M)(p> 0.05); and 50-59 years had 90.90%(F) vs. 92.42%(M) (p> 0.05) were higher thannormal risk for 30-years CVD. About the age, in female, by comparing the average riskCVD found and average risk CVD expected in the group: 20-29 years (4%vs.3%) (p>0.05); 30-39 years (12%vs.9%) (p> 0.05); 40-49 years (27%vs.15%)(p <0.05); 50-59years (46%vs.24%) (p <0.05). About the age, in male, by comparing the average risk CVDfound and average risk CVD expected in the group: 20-29 years (9%vs.6%) (p <0.05); 30-39 years (20%vs.13%) (p <0.05); 40-49 years (37%vs.24%) (p <0.05); 50-59 years (56%vs.36%) (p <0.05).Conclusion: In the age group 20 to 40 years male had higher 30-years CVD risk thanfemale. The average found for 30-years CVD risk was higher than the average expected inall age male groups and female groups over 40 years.. Therefore, it is necessary to improvepreventive care in riverside communities.Disclosure of Interest: None Declared

GHEART Vol 9/1S/2014 j March, 2014 j POSTER/2014 WCC Posters

PM267

Effects Of Listening To Joyful Music On Endothelial Function In Rehabilitation OfPatients After Myocardial Infarction

Marina Deljanin Ilic*1, Stevan Ilic1, Gordana Kocic2, Radmila Pavlovic2, Viktor Stoickov1,Dejan Simonovic11Cardiology, Institute of Cardiology, Medical Faculty University of NIS, 2Institute ofBiochemistry, Medical Faculty University of NIS, NIS, Serbia

Introduction: In the setting of cardiovascular disease the endothelium loses its normalfunction. Exercise training has been shown to improve endothelial function, however littleis known about the role of music in cardiovascular rehabilitation or the effects of listeningto favourite music on endothelial function.Objectives: To evaluate the effects of listening to joyfulmusic on the endothelial function, assessthrough changes of circulating bloodmarkers of endothelial function: the stable end products ofnitric oxide (NOx), S – nitrosothiols (RSNO – reservoir for bioavailable nitric oxide), andasymmetric dimethylarginine (ADMA) in patients (pts) after myocardial infarction (MI).Methods: 50pts after MI were studied. At baseline and 3 weeks later, in all pts values of NOx,RSNOandADMAwere evaluated andexercise testwasperformed.After the initial study,patientswere randomized to music (M,n¼20) and control (C,n¼30) group. Patients in both groupsunderwent a supervised 3 weeks aerobic exercise training at residential center. Additionaly toexercise trainingpatients inMgroupwere listening their favoritemusic forhalf anhour everyday.Results: Baseline values of NOx, RSNO and ADMA were similar in M and C group. After 3weeks value of NOx increased significantly in M group (from 32.7 � 9.0 to 49.0 � 10.5mmol/l, P<0.001), as well as in C group (from 32.5�12.0 to 42.0�11.0 mmol/l, P<0.005),however increase in NOx was higher in M than in C group (49%vs 30%) compared tobaseline values. In both groups, value of RSNO increased after 3 weeks: in M group RSNOincreased from 3.2�1.3 to 5.3�1.3 mmol/l (P<0.001) and in C group from 3.1�1.6 to4.5�1.4 mmol/l (P<0.001). After 3 weeks increase in RSNOwas higher in M than in C group(65% vs 45%), compared to baseline values. Value of ADMA decreased in both groups (ns)after 3 weeks, and this reduction was greater in M than in C group (13.7% vs 8.2%).Conclusion: Listening to joyful music in combination with regular exercise training pro-gram leads to more pronounced benefit and improvement of endothelial function thanexercise training alone. Therefore, listening to joyful music may be an adjunct method inthe rehabilitation of patients after myocardial infarction.Disclosure of Interest: None Declared

PM271

Plasma lipidomic analysis predicts soft coronary artery plaque in asymptomaticpatients at intermediate risk of coronary artery disease

Andris H. Ellims*1, Gerard Wong2, Jacquelyn M. Weir2, Philip Lew3, Peter J. Meikle2,Andrew J. Taylor11Heart Centre, Alfred Hospital and Baker IDI Heart & Diabetes Institute, 2Baker IDI Heart &Diabetes Institute, 3Department of Radiology, Alfred Hospital, Melbourne, Australia

Introduction: The optimal management of asymptomatic subjects at intermediate risk ofcoronary artery disease (CAD) is often uncertain. Re-stratification to a high or low riskcategory may enable optimization of preventative strategies. Coronary computed tomo-graphic angiography (CCTA) enables a minimally invasive assessment of coronary arteryplaque quantity and composition. Soft plaque by CCTA is lipid-rich and more vulnerableto rupture and resultant acute coronary syndromes.Objectives: To determine whether novel approaches to CAD risk stratification, such asplasma lipid profiling, may predict soft plaque burden in intermediate risk subjects.Methods: CCTA and several markers of CAD (including plasma lipid profiling, carotidintima-media thickness, aortic pulse wave velocity, and C-reactive protein) were pro-spectively performed in 100 asymptomatic patients at intermediate CAD risk according tothe Framingham risk score. Segment stenosis scores (SSS) were calculated to evaluate theburden of total, calcified, and soft coronary artery plaque.Results: Soft plaque was observed in 66 subjects and 158 of 1425 (11%) coronary arterysegments. 18 lipid species demonstrated significant associations with soft plaque burden,but not with total plaque or calcified plaque burden. No other marker of CAD was found topredict coronary artery plaque burden.Conclusion: Plasma lipidomic analysis can predict the burden of soft coronary arteryplaque in asymptomatic subjects at intermediate risk of CAD. Given that soft plaque islinked to an increased risk of future acute coronary events, plasma lipid profiling may allowre-stratification of these patients to a higher or lower risk category and, thereby, enablemore appropriate and effective primary prevention management strategies.Disclosure of Interest: None Declared

PM272

Could Routine Laboratory Parameters Predict The Severity Of Coronary ArteryLesions? Preliminary Study

Benny M. Setiadi*1, Hariman Kristian1, Bambang Budiono2, Agnes L. Panda1,Janry Pangemanan1, Reggy Lefrandt11Cardiology and Vascular Medicine, Sam Ratulangi University, Manado, 2Cardiology andVascular Medicine, Awal Bros Hospital, Makassar, Indonesia

Introduction: Several studies have reported the association between several laboratoryparameters to severity of coronary artery lesions; however each of those parameters wereanalyzed in different population.

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