Weight Loss (ITT-MI)

Plenity™ (n=223)

Placebo (n=213)

169 171

-4.39

-6.41

Wei

ght

Cha

nge

fro

m B

asel

ine,

%

0

-2

-4

-6

-8

-12

0 30 60 90 120 150

Study Day

Weight Loss (ITT-MI)

Plenity™ (n=223)

Placebo (n=213)

169 171

-4.39

-6.41

Wei

ght

Cha

nge

fro

m B

asel

ine,

%

0

-2

-4

-6

-8

-12

0 30 60 90 120 150

Study Day

Plenity™

Plenity™

Placebo

n = 17

n = 18

GLOW GLOW-EX

GLOW GLOW-EX

0 30 60 90 120 150 180 210 240 270 300 330

Study Day

0

0

-2

-4

-6

-8

-10

-12

0

-2

-4

-6

-8

-10

-12

30 60 90 120 150 180 210 240 270 300 330

Study Day

Cha

nge

in W

eig

htfr

om

Bas

elin

e, %

Cha

nge

in W

eig

htfr

om

Bas

elin

e, %

GLOW-EXStart

GLOW-EXStart

Plenity™

Plenity™

Placebo

n = 17

n = 18

GLOW GLOW-EX

GLOW GLOW-EX

0 30 60 90 120 150 180 210 240 270 300 330

Study Day

0

0

-2

-4

-6

-8

-10

-12

0

-2

-4

-6

-8

-10

-12

30 60 90 120 150 180 210 240 270 300 330

Study Day

Cha

nge

in W

eig

htfr

om

Bas

elin

e, %

Cha

nge

in W

eig

htfr

om

Bas

elin

e, %

GLOW-EXStart

GLOW-EXStart

Plenity™

Plenity™

Placebo

n = 17

n = 18

GLOW GLOW-EX

GLOW GLOW-EX

0 30 60 90 120 150 180 210 240 270 300 330

Study Day

0

0

-2

-4

-6

-8

-10

-12

0

-2

-4

-6

-8

-10

-12

30 60 90 120 150 180 210 240 270 300 330

Study Day

Cha

nge

in W

eig

htfr

om

Bas

elin

e, %

Cha

nge

in W

eig

htfr

om

Bas

elin

e, %

GLOW-EXStart

GLOW-EXStart

Plenity™

Plenity™

Placebo

n = 17

n = 18

GLOW GLOW-EX

GLOW GLOW-EX

0 30 60 90 120 150 180 210 240 270 300 330

Study Day

0

0

-2

-4

-6

-8

-10

-12

0

-2

-4

-6

-8

-10

-12

30 60 90 120 150 180 210 240 270 300 330

Study Day

Cha

nge

in W

eig

htfr

om

Bas

elin

e, %

Cha

nge

in W

eig

htfr

om

Bas

elin

e, %

GLOW-EXStart

GLOW-EXStart

200

400

600

800

1000

1200

1400

1600

1800

2000

0

200

400

600

800

1000

1200

1400

1600

1800

2000

0

0 2 4 6 8 10 12 14 16 18 20 22 24

Metformin - Fasting (n=24)

Plenity • Metformin - Fasting (n=23)

Nominal Time (hours)

0 2 4 6 8 10 12 14 16 18 20 22 24Nominal Time (hours)

7a: Fasted

7b: Fed

Pla

sma

Co

ncen

trat

ion

(ng

/mL)

Pla

sma

Co

ncen

trat

ion

(ng

/mL)

Metformin - Fed (n=24)

Plenity • Metformin - Fed (n=24)

200

400

600

800

1000

1200

1400

1600

1800

2000

0

200

400

600

800

1000

1200

1400

1600

1800

2000

0

0 2 4 6 8 10 12 14 16 18 20 22 24

Metformin - Fasting (n=24)

Plenity • Metformin - Fasting (n=23)

Nominal Time (hours)

0 2 4 6 8 10 12 14 16 18 20 22 24Nominal Time (hours)

7a: Fasted

7b: Fed

Pla

sma

Co

ncen

trat

ion

(ng

/mL)

Pla

sma

Co

ncen

trat

ion

(ng

/mL)

Metformin - Fed (n=24)

Plenity • Metformin - Fed (n=24)

200

400

600

800

1000

1200

1400

1600

1800

2000

0

200

400

600

800

1000

1200

1400

1600

1800

2000

0

0 2 4 6 8 10 12 14 16 18 20 22 24

Metformin - Fasting (n=24)

Plenity • Metformin - Fasting (n=23)

Nominal Time (hours)

0 2 4 6 8 10 12 14 16 18 20 22 24Nominal Time (hours)

7a: Fasted

7b: Fed

Pla

sma

Co

ncen

trat

ion

(ng

/mL)

Pla

sma

Co

ncen

trat

ion

(ng

/mL)

Metformin - Fed (n=24)

Plenity • Metformin - Fed (n=24)

200

400

600

800

1000

1200

1400

1600

1800

2000

0

200

400

600

800

1000

1200

1400

1600

1800

2000

0

0 2 4 6 8 10 12 14 16 18 20 22 24

Metformin - Fasting (n=24)

Plenity • Metformin - Fasting (n=23)

Nominal Time (hours)

0 2 4 6 8 10 12 14 16 18 20 22 24Nominal Time (hours)

7a: Fasted

7b: Fed

Pla

sma

Co

ncen

trat

ion

(ng

/mL)

Pla

sma

Co

ncen

trat

ion

(ng

/mL)

Metformin - Fed (n=24)

Plenity • Metformin - Fed (n=24)