Post on 13-Aug-2015
Bringing nanobots into measurement science
6/27/2015Project1
Microrheometer using nanopropellers
Arijit GhoshElectrical Communication Engineering/ Centre for Nano Science & Engineering,
Indian Institute of Science, Bangalore
Contact: ghosharijit.7@gmail.com
The problem
6/27/2015Project2
Fast mapping of the local mechanical properties of a soft medium having microscale heterogeneities.
Target systems (Industry and laboratory level):
Phase separation or gelation studies
• Food gels and emulsions • Polyphasic Polymers used in polymer industries or proteins used in drug manufacturing or analysis.
Potential uses in disease diagnosis.
Analysis of blood or mucus found in intestinal/ lung/ reproductive tract, Synovial fluids, Extra/Intracellular fluids
Proposed Solution
6/27/2015Project3
Mapping the rheologicalproperties of a complexheterogeneous medium,while the propeller is movedaround.
Rotating Magnetic FieldGeneralized Theory of the
Dynamics(Validated by Experiments)
Product Details
6/27/2015Project4
Analysis Chamber
Actuation system
Imaging system
Image Processing
Small Volume of Test Fluid
Envisaged Rheometer
Rheological properties like Viscosity/ Elasticity/ Compliance
Dimensions: 1’ ×1’ × 1’ Weight : 1 – 2 kgs
Unique Selling Points
6/27/2015Project5
Methods
Features
Bulk Rheology
Passive Rheology
Opticalmicrorheology
Magnetic Tweezers
Our Method
Measurement Time
10 - 100 sec > 100 sec 1-10 sec 1-10 sec < 0.1 sec
Probing heterogeneity
Range of modulus measurement
0.01 - 100 Pa.s 0.001 - 0.1 Pa.s 0.001 - 0.1 Pa.s 0.001 - 1 Pa.s 0.001 - 1 Pa.s
Frequency range of operation
100 Hz 1000 Hz 100 Hz 100 Hz 100 Hz
Sensitivity for quick measurements
Sample volume required
~ 1 ml ~ 1 μl ~ 1 μl ~ 1 μl ~ 1 μl
Rheological Mapping
Technology vis a vis Benefit Mapping
6/27/2015Project6
Small Volume of Test Fluid
Fast and accurate measurements
Microrheologicalmapping
Rheometer based on nanopropellers and video microscopy
Suitable for expensive and rare samples
Suitable for repeated measurements
Suitable for dynamic viscosity mapping
Probing Heterogeneities
Low Cost
Competition Analysis
6/27/2015Project7
Nanopropellerbased rheometry
Bulk Rheometry
Optical Tweezers
Anton Paar, Thermo Scientific, Brookefield, etc.
Passive Rheology
Thorlabs, Mmi, etc.
Beckman Coulter, Malvern etc.
Magnetic Tweezers
Extensively used in research labs,No prominent company
How will we make money ?
6/27/2015Project8
Path to Commercialization:
Proof of Principle Prototype development and searching Investors
We are here
Market Research
Voice of Customer
Commercialization
Who is our customer ? Biopharmaceuticals and bio research labs. Food industries Petroleum industries Polymer industries (e.g. photoresists/paints)/ Companies manufacturing rechargeable batteries. Consumer products industries (FMCG) (Unilever/Procter & Gamble) Disease diagnostics.
Why us ?
6/27/2015Project9
Skills and Expertise:
Pioneering Work
Ambarish Ghosh & Peer FischerRowland Institute at Harvard
Nanoletters 2009
Experimental and Theoretical foundations
Physics/ Physical Chemistry
Physical Review E 2012Arijit Ghosh et. al.(Engineering)
PCCP 2013Arijit Ghosh, Pranay Mandal et. al.
PI: Dr. Ambarish Ghosh
6/27/2015Project10
GIVEN AN OPPORTUNITY, WE CAN!!!
Why do we believe that we can make this happen ?
Potential to replace bulk rheometry as well (Anton Paar)
Scope of growth---not only rheology
Clear advantages over existing techniques of microrheology