Oncomics.deanticancer drug development

and theranostic service

Main anticancer drug developmental problem is: pharma R&D have NO model for specific pharmacological activity – we can try medication efficiency on patients only

• In vitro cell cultures (even 3D, primary, long-term, ets.) - not representative

• Murine cancer models (both mice and rats)– not representative

In vitro 3D cultures Ex vivo In vivo mousecancer model

Oncomics ex vivo primary cancer growing model. A lot of different cell types.

Due to cancerplasticity:differentcell types with functional heterogeneity among cancer cells in some tumors

Why?

At the present time reliable results of the anticancer drugs effects can be only if we grow human cancer in mice

Human cancer in miceHuman

cancer

Project mission is: the providing of powerful high-tech tools set service for anticancer drug discovery:

•Targeted Cancer Therapies•Radiotracers for Oncology •Clinical Oncology and Science

1. Cancer tissue isolation- Cancer tissues:

- surgery- open biopsy- laparoscopic

biopsy- surface biopsy

- Body liquids- Blood

2. Liquid biopsy growing- Fast biopsy blast

growing method*:- 3 day- 1 week

- Low speed biopsy growing method*:

- up to 1 year

*know how

3. Engraftment tumor in PDX- Mice tumor

engraftment :- P0-P12 PDX- Orthotopic and

heterotopic surgery transplantation

4. Cancer growing visualization

Mice magnetic resonance imaging (MRI)

Mice computed tomography imaging (CT)

5. Treatment examination

2.Chemotherapy or/and radiotherapy

1.Mice cancer engrafting

4.Analysis(DNA damage imaging)

1.1.And liquid biopsycultivation

3.Surgery isolation

6. Blast clones growingCancer tissue clones «fast growing»

- ex vivo clones

PD-1 PDL-1 CTLA4

7. Surgery facility

Cancer tissue surgery and isolation

8. Metastatic PDX model

Metastatic cancer PDX models

General technics:- Cancer tissue isolation: all types of cancer

can be used* and any surgery technics can be performed;

- Fast or slow primary cancer liquid biopsy growing;

- Engraftment the cancer in mice (PDX);

- Treatment, surgery and treated cancer tissue examination

* All types of cancer which can be grown – cancer must be able to grow in models.

- ceo@oncomics.de oncomics@outlook.com

Key features:- Whole research cycle – «only medication

from the pharma company-client»;

- Treatment mice with human protocols and with the same instruments;

- Lead scientific and oncologists administration;

- Human experimental treatment (in accordance with the official protocols);

- ceo@oncomics.de oncomics@outlook.com

Key techniques:- Primary cancer tissues are used

(maximally representative of the patient tumor clone structures)

- Cancer therapy combination can be performed (e.g. combination of chemotherapy, radiotherapy and target therapy)

- ceo@oncomics.de oncomics@outlook.com

Animal protection note:- Our research protocols

exclude the premeditated killing of animals

Thank you for attention!

- ceo@oncomics.de- oncomics@outlook.com