Nutritional Therapies for Mental Health - Dr. Leslie Korn...GLANDULAR BENEFIT DOSE RANGE Adrenal...

LeslieKorn,PhD,MPHLMHC,ACS,RPP,NTP,NCBTMB

CopyrightDr.LeslieKorn,2020

Nutritional Therapies for Mental Health 

Copyright,LeslieE.Korn,2020


Principle

“Diet is essential but not sufficient”

— Leslie Korn


Ethics & Nutritional Supplementation

• Rememberourethicsmodule&yourroleinnutritionalsupplementation

•Dependsonthestatewhereyoupractice• Yourscopeofpractice• Competency

• Identifyyourroleasprimaryorreferring&collaborative• Betheclinicianwhoknowsabouttherangeofoptionsevenifyoudon’trecommendorprescribe


•AddressCauseofdis-ease/imbalances•⬇inflammation&oxidativestress•Managestressresponse•Enhancemitochondrialfunction•BalanceCircadianrhythm•Enhanceneuronalcommunication•AddressEpigenetics• Howfoods&nutrientscanaltergeneexpression

Goals of Nutritional Therapy


Goals of Nutritional Therapy

• IdentifyBiochemicalindividualneeds• Enhancedigestion&utilizationofnutrients• Delivereasilyassimilatedhighdosenutrients•Manage/reduce/eliminatesymptoms• Alternatives/synergiststopharmaceuticals• Identifyadherencestrategiesincludingdose&delivery

Copyright,LeslieE.Korn,2020 7

Supplement Dosing

•Treattheindividual,notthedisease/symptom•Spreaddesiredeffectsacross4broadareas

• Vitamins,Minerals,AminoAcids&Glandulars

•Tailorprotocoltoclientneeds•Planforincrementalchange•Lowerdosesthat⬆slowly•Adjustchildren’sdoses•Age&bodyweight


Supplement Dosing

•Highquality,naturalformsupplements

•Lookforfoodsourcesofvitaminsonlabelor100%natural

•Readlabels• Lowerqualityvitamins(additives,fillers&foodcoloring)

•Useafewsupplementstocombinemostofwhatyouneed


•Balanceuseofvitamins,minerals,fats,botanicals&glandulars

•Review&adjusttheprotocolevery3-6months

•Startslowly&buildaccordingtoadherence

•Startw/whereyouwillobservefastest&mostimportantchangesfirst;eg.Anxiolytic/antidepressantetc.

Dosing: Vitamins, Minerals, Botanicals & Glandulars


Contraindications & Side Effects

Nutrients may • Slowor⬆metabolism• Excretionofcertainmedications

• Potentiate/synergizeactionofcertainmedications

• Exacerbateexistinghealthconditions

•Becontraindicated


•5-HTP,Melatonin•Kava,St.JohnsWort

•Mixingofnutrients,drugs&herbs•Nutrientdeficitsasaresultofmedications

•Comprehensivedrug-nutrient-herbanalysis

Keeping Your Clients Safe

www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker

http://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker

Best Vitamins, Minerals, Amino Acids, Fats, Glandulars, & Special Nutrients


•B-Vitamins&Minerals•FreeAminoAcids•Fats(dietary&supplemental)

•Probiotics•Glandulars

Core Nutrients for Mental Health


•Integratefood&nutrients•Usepowdered/liquidnutrients•AddFish&Borage/CoconutOils

•Probioticspowder•Protein(whey,pea,hempprotein)

•Berries,Chocolate,Stevia

How to Take Nutrients? Smoothies


Essential Vitamins

Vitamins •Water-soluble•Dissolvedinwater&arenotstoredinthebody•Riskofoverdosingisverylow

•Fat-soluble•Absorbedbyfat•Requiresufficientdietaryfatstobestoredinbodytissues


•Neurohormonenotavitamin•AnnualserumVitaminDtesting:levels50-80/ng/mL•VitaminDreceptorsinbrain⬆serotoninproduction(Holick,2003)•ImprovesMitochondrialfunction•Deficiencyassociatedw/depression&pain,immuneproblems•High%ofdeficiencyinUSpopulation• Sinha,Hollingsworth,Ball,&Cheetham,2013

First Steps: Vitamin D Deficiency


Vitamin D

• Helpsbodyabsorbcalcium,magnesium,phosphate,iron,&zinc• CholesterolisaprecursortovitaminD• (Vasquez,Manso,&Cannell,2004)• 5000IU/dayor• Oraldoseof50,000IUofvitaminDonceaweekfor8weeks• Long-termprevention=50,000IUofvitaminDonceortwiceamonth• Emulsifieddrops

• Holick,Michael.DepartmentofMedicine.DivisionofEndocrinology,Diabetes,andNutrition.BostonUniversitySchoolofMedicine,Boston,MA.


B Complex Vitamin

•StartwithB-complex•Coresupportforbrainfunction

• eg.B-6supportsNTfunction;supportsbloodglucose

•Relaxation,cognition, &neurologicalhealth

•➡cofactorsinneurotransmitters


Vitamin B9

•Folate,naturalform• Invarietyofplant&animalfoods

•Folicacid,syntheticform•Usedinsupplements&fortifiedfoods

•Strongcorrelationbetweenadeficiencyinfolate&depression

•Avoidfolicacid


•MTHFR(Methylenetetrahydrofolatereductase)• Enzymeneededtoconvertfolate• ConvertshomocysteinetomethionineessentialforNTdevelopment

•GeneticMTHFRvariation:estat40%unabletoconvert• Individualswiththisgeneticvariation(Singlenucleotidepolymorphism(snp)take

• Implications?depression,bipolardisorder,schizophrenia,attention-deficithyperactivitydisorder(ADHD),autism,homocysteine

Folate, 5-MTHF & Genetics


Vitamin B9& MTHFR

•Take:L-methylfolate,fewtonosideeffects• Ifsystemicinflammationishigh:experienceirritability, &insomnia

•Startatlowdose• IncludesupplementalMethylB-12,&Niacin


Vitamin B3

•Niacin&niacinamide• Depression,anxiety,&alcoholaddiction•Niacincauses(unpleasant)flushing

•Niacinamide➡GABAreceptors•Moodstabilization&sedative,arthritis,•Anxiety,depression,insomnia,dementia&alcoholwithdrawal(Prousky,

2005)


Vitamin B3

• Largedosesforschizophrenia(Hoffer,1962)• 15gramofL-methylfolate(or500mgofthiaminet.i.d.)• 3-8gramsofNiacinamide,toimproveoutcomesalongsidetheuseconventionalantipsychotics(Lake,2006)

Contraindications

•Niacinabove3,000mg.aday:monitorresponsewithhealthprofessional

• Possiblenausea&vomitingathighdoses


Vitamin B6

•B6deficiency➡insomnia,hypertension,PMS,&irritability

•Depression&anxiety•SSRIformulationsoftencontainaddedB-6

•Pyridoxal5’-phosphate(P5P):preferredform•(50-100mg)•ActivecoenzymeformofvitaminB6


Vitamin B8

• Inositoleffectivefordepression,panicattacks,agoraphobia,obsessivecompulsivedisorder,bulimianervosa,&bingeeating

(Gelber,Levine,Belmaker,2001)

•⬇OCDsymptoms• (Levine,1997)

•MoreeffectivethanfluvoxamineinthereductionofOCDsymptoms

(Gelberetal.2001)

Startat2000mg. Highdosesabove10,000mgcanupsetstomach


Vitamin B12

•B12--essentialvitamin•Depression,fatigue,anxiety,cognition&psychosis•Co-factorinmethylationleadingtoSAMe•Sublingual:1-5mg/day•Elders,lowproteinandvegetariansatrisk•MetformindepletesthebodyofB12• (Prousky,2005)


Choline

•Naturallyincellmembranelipidsinbrain• Beefliver,egg,fish,chickenandmilk•Synthesisofacetylcholine:memory&learning•3commonlyusedforms•CDP-Choline(cytidine-5’-diphosphatecholine)A.K.A.citicoline

•BreaksdownintoPhosphatidylcholine•ThenintoAlpha-GPC


Choline

Vegetarians,vegansandexcessamountsofalcoholincreaseriskofcholinedeficiency

CDP-cholineacceleratedrecoveryinheadtraumapatients(Secades&Frontera,1995)

• 500mg.CDP-cholinetwicedailymayhelp⬇cravingsforcocaine(Renshaw,Daniels,Lundahl,Rogers,&Lukas,1999)

• Combinedwithlithium(carbonate)reducesmanicsymptomsinbipolardisorder

(Lyoo,Demopulos,Hirashima,Ahn,&Renshaw,2003)


Vitamin C

•QualityvitaminCisaComplex(notjustascorbicacid)

•Containsbioflavonoids&rutin

•Eatingcitrusfruits’pulpprovidesbioflavonoids


Fat Soluble Vitamins

•A•D• E•K•Needfattoabsorbtheseessentialvitamins•Besttakenw/ahigherfatmeal• Lowfatdietsatriskfordeficiency


Vitamin A

•Agroupofcompoundscalledretinoids•Eyes•Immunesupport•Skin•Lungs


Vitamin E•8fat-solubleantioxidantcompounds•Tocopherols&tocotrienols•⬆vitaminEassociated•⬇riskofcognitivedecline/Alzheimer’s

• Evidencesuggeststakingseparately• Tolowerinflammationmarkers

• 250mg/day.Annatto-derivedtocotrienols• (Mangialascheet.al.,2012,2013)


Vitamin K•SupplementationshouldincludebothformsK1&2•K1(phylloquinone):Higherlevelsassociatedwithbettercognitivefunctioninelders(Presseetal.,2013)

• K2(menaquinone):essentialfornervehealthinthebrain

• 100mcgofvitaminK2(MK-7)• 1,000mcgofvitaminK2(MK-4);&1,500mcgofvitaminK1• Oralanticoagulantsdoubleratesofdepression

Contraindications: People taking anticoagulants (Warfarin) https://academic.oup.com/ehjcvp/advance-article/doi/10.1093/ehjcvp/pvz085/5699907

https://academic.oup.com/ehjcvp/advance-article/doi/10.1093/ehjcvp/pvz085/5699907https://academic.oup.com/ehjcvp/advance-article/doi/10.1093/ehjcvp/pvz085/5699907


Essential Minerals

• “Sparkplugs”(Watts,2006)•Macrominerals•Bodyneedstheminlargeramounts•Calcium,phosphorus,magnesium,sodium,potassium,chloride&sulfur

• Traceminerals• Smallamounts• Iron,manganese,copper,iodine,zinc,cobalt,fluoride&selenium


Chromium

•Depression&moodregulation•Effectiveindecreasingcarbohydratecravings&bingeeating(Brownley,VonHolle,Hamer,LaVia,&Bulik,2013)

•Chromiumpicolinate500-1000mcg


Calcium

•Overuseofcalciumsupplementsbypost-menopausalwomen

•➡fatigue,exhaustion,headaches,depression,anxiety&insomnia

(Watts,2006)

•Overconsumptionmayinhibitzinc,phosphorous,&copperabsorption

•Handout:Calcium-richsouprecipe


Lithium

•UseforcognitionandMooddisorders(Schrauzer&deVroey,1994)

• LengthensCircadianRhythm•Neuroprotective&anti-inflammatory•⬆hippocampalvolume,⬆brainderivedneurotrophicfactor(BDNF)

•⬇riskofAlzheimer’sinbipolarpatientswhotakeitregularly

(Diniz,Machado-Vieira,&Forlenza,2013)

• LithiumOrotate20-50mg


Lithium

• Peoplew/BiPolar,depression,cognitivedecline&memoryloss(Forlenzaetal.,2011);(Nunes,Viel,&Buck,2013)

• Alcoholrecovery&relapseprevention(Sartori,1986)

• Lithiumorotatecrossesblood-brainbarrier• Carbonateformdoesnot

Contraindications •Nottobetakenbypregnant&lactatingwomen


Magnesium

•Anxiolytic,anti-stress•Supportscognitivefunction&mood•Deficiencyiscommon•Improvesserotoninsynthesis•Reducesinflammation&oxidativestress•Muscletension,sleep•Aspartate:aseffectiveaslithiumin50%ofseverelyillrapid-cyclingbipolarpatients

(Chouinard,Beauclair,Geiser,&Etienne,1990)


Magnesium

•Mostabsorbableformsofmagnesium• Glycinate• L-threonate,anewformdevelopedtocrossthebloodbrainbarrier.Improvesshort-termmemory

(Abumariaetal.,2011)

•⬆overallcognitivefunction(Slutskyetal.,2010)

• Antidepressant&candampentraumaticmemories(Abumaria,Yin,Zhang,Zhao,&Liu,2009)


Magnesium Threonate

•Significantly⬆levelsofmagnesiumwithinbrain

•Maintainsthequantityofsynapticconnectionsbetweenbraincells

•Improvedshort&longtermmemory(SlutskyI,AbumariaN,WuLJ,HuangC,ZhangL,LiB,ZhaoX,GovindarajanA,ZhaoMG,ZhuoM,TonegawaS,LiuG.2010)(LiW,YuJ,LiuY,HuangX,AbumariaN,ZhuY,HuangX,XiongW,RenC,LiuXG,ChuiD,LiuG1.2014)

41


Potassium

•Deficiency➡Bulimia&anorexia

(Higdon,2004)

•Potassiumorotate&citrateveryeasilyabsorbed


Selenium

•Elevatesmood,reducesinflammation,enhancesimmunity

Contraindications •Veryhighdosesofseleniumcanbetoxic


Zinc

•Antidepressant(Levenson,2006)

•Cognitivefunctioninelderadults

(Mayloretal.,2006)

•Useinbulimia&purging,anorexiadisorder

•Picolinate25-50mg/day


Copper

•Regulatescellularenergyproduction&neurotransmission

•High&Lowcopperlevelslinkedtodepression• Source:wellwater

•Antacidsinterferew/theabsorptionofcopper


Iodine

•Foodsources• Seafood,seaweed&iodizedsalt

•Benefitsfatigue,ADHD&ASD


Iron

•Irondeficiency⬆riskofmooddisorders,autismspectrumdisorder,attentiondeficit,hyperactivitydisorder

(Chenetal.,2013)

•Irondeficiency⬆fatigue,anemia,poorcognitivefunction&developmentaldisorders

•VitaminC⬆ironabsorption•Cookw/castiron•Floradix


Rubidium

PrimarydietarysourceofRbisredmeat. Processedmeatscontainahighconcentrationofrubidium. Brazilnuts,pecans,sesameandsunflowerseeds,potatoskins, eggplant,mushrooms,cucumber,avocado,andmeatbones

Usefordepressionspecificallystimulatescatecholamine(dopamine, norepinephrine; and epinephrine) pathways

Activatesthesynthesisof5-hydroxytryptophan


Rubidium

Usefordepressionindialysispatients

MerckManual,1940:useashypnoticand‘nervousafflictions”

500mg/dayRB-zyme

https://www.ncbi.nlm.nih.gov/pubmed/8412574https://www.ncbi.nlm.nih.gov/pubmed/8926857


Antioxidants

• Body’ssystemofprotection➡neutralizefreeradicals• Excessoxidation➡toomanyfreeradicalsforantioxidantstoneutralizethem➡“oxidativestress”• ⬆Celldestruction• N-acetylcysteine• Boostsproductionofglutathione• Alphalipoicacid• CoenzymeQ10(CoQ10)• MilkThistle


Probiotics

•FermentedfoodsorSupplements

•Heatstabilizedorneedrefrigeration•Intakeofprobioticsmayreducenegativethoughtsassociatedw/sadmood

(Steenbergen,Sellaro,vanHemert,Bosch,Colzato,2015)


Essential Fatty Acids

• DHA,aconstituentoffishoil•⬆communicationbetweensynapses•⬆dendriticspinesonpostsynapticneurons• Higherbloodlevelsoffishoil=w/⬆brainvolume

(Pottalaetal.,2014)

• TheFishOilYouthDepressionPilotStudy(1.4gms)• Min.of2000mgadayforeffect• Upto20gm.dailyoffishoilforthetreatmentoftraumaticbraininjury(Lewis,Ghassemi,&Hibbeln,2013)


Gamma Linoleic Acid (GLA)

●GLA-richplantoils●Borageseed

● derma●Eveningprimroseseeds

● menopause●Blackcurrantseed●Uterinecramp/PMS●Hemp●500-1000mg/day


Medium Chain Fatty Acids & Cognition

•⬆ketonebodies:improvescognition&memory

•SignificantresearchforMCT&cognitiverepair•Promotes&nourishesneuronalcommunicationby⬆growthofdendrites(nerveendings)

•Coconut,Palm(lesseringrassfedbutter)•AddrawButter&coconutfattocoffee


•Aminoacidsareprecursorstoneurotransmitters

•Productionofneurotransmittersisaffectedbyaminoacidsindiet

•Poordiet/lowprotein⬇neurotransmitters•PoorFats⬇neuronalcommunication•EFA’saresynaptic“lube”

Amino Acid Therapy


Amino Acids

•Aminoacidtherapies=alternativetopsychotropicpharmaceuticalmedications

•Freeaminoacids

Contraindications •Peoplew/tardivedyskinesiashouldnottakephenylalaninesupplements


NT’S AMINO ACIDS/ NUTRIENTS BOTANICALS FOODS ENTHEOGENS

GABAGlutamine,taurine, lactium,

LithiumorotateValerian,hops,skullcap,

greentea,kava

Walnuts,oats,spinach,beansliver,

mackerel

Amanitamuscaria,Muscimol

SerotoninTryptophan, 5HTP,B-vitamins,(B-12,

B-6niacinamide),folateSt.John’swort

Salmon,beef,lamb,figsbananas,root

vegetables,brownrice

LSD,Psilocybin,DMT,Ibogaine,Ayahuasca

Dopamine Tyrosine,DL- Phenylalanine,B-12,B-6 Ginseng,FenugreekCoffee,tea,eggs,

pork,darkchocolate,ricottacheese

MDMA/MDE Mescaline

Norepinephrine Tyrosine StJohn’swort,Holybasil,licorice Meats,fishescheeseMDMA/MDE Mescaline

AcetylcholineGPCcholine, phosphatidylserine, acetyl-L-carnitine, huperzine

Sage,Bacopa,Melissa,Ginkgo,Ashwaganda

Eggs,liver,salmonshrimp,nutbutters,

coffee

Scopolamine(contraindicated)

Glutamate GlutamicAcid GotuKola,Kava,PassionflowerCaffeine,fermentedfoods,chicken,eggs,

dairy

Ketamine Ibogaine

Endogenousopioids

Lactium PapaversomniferumCasein(milk),gluten(grains),spinach,fat,

fasting

Ibogaine, Salviadivinorum

Cannabinoids Fishoil,lactobacilli Cannabis Hempseeds/hempoil Cannabis


Theanine

•Aminoacidfoundingreen&blackteas

•Crossestheblood–brainbarrierwhereitactsasananxiolytic

•Canenhancedreams


•FreeAminoAcids•B-ComplexwithB-6&B-12•Magnesium•Theanine•Curcuminw/BlackPepper•Tyrosine(rhodiola)•Eggs,Eggs&moreEggs-Acetylcholine

Top 7 Nutrients Essential for Neurotransmitter Balance


Coenzyme Q10

•Vitaminlike,fat-solublesubstancefoundinmitochondria•Twoforms:ubiquinol&ubiquinoneubiquonolmaybemoreeffective

•Beneficialfortreatmentofbipolar,depression,fatigue,fibromyalgia&schizophrenia,mitosupport

Contraindications • Canreducethebody’sresponsetobloodthinning(anticoagulant)medicine• Can⬇insulinrequirementsinpeoplew/diabetes

• Stainsdepletethereforeneedtosupplement


Lactium

•DevelopedinFrance•Genericnameofbioactivemilk-derivedpeptides•ActsonGABAreceptors•⬇stress&cortisollevelswhileinducingrelaxation&improvingmentalfunction

•⬆sleep

(Clare&Swaisgood,2000);(Delini-Stula&Holsboer-Trachsler,2009);(deSaint-Hilaire,Messaoudi,Desor,&Kobayashi,2009)


Melatonin

•Hormonesynthesizedasthefinalmetabolitebythetryptophan-serotoninpathway

•Theuseoftryptophanor5-HTPmayeliminatetheneedformelatonin

Contraindications •Alpha-&beta-blockingdrugsusedforhypertensioncandisruptsleepby⬇melatoninrelease

(Stoschitzkyetal.,1999)


Phosphatidylserine

•Phospholipid:keycomponentofcellmembrane•Essentialfortransferofbiochemicalmessagesintocellswithinbrain&centralnervoussystem

•RegulatescortisollevelsviatheHPA-axis•⬆acetylcholineinbrain•Supportsmemoryinchronicstress,depression,ADHD,PTSD&TBI

•Eggyolks&liverrichPSsources•100/mgdayHPAaxis


Bromelain

•Inhibitscyclooxygenaseenzyme•Inhibitssynthesisofprostaglandin2

•Breaksdownfibrin&reducesswelling

•Foundationofanti-inflammatorytreatment

•Useforpain&fibromyalgia (withCoq10)


RNA/DNA Supplements

• Recoveryfromillness&surgery• Cognitivefunction• Immunesupport• Diet• Proteins,synthesisfromaminoacids&glucose

• Supplements• Four“ribonucleotides”CytidineMonophosphate(CMP),UridineMonophosphate(UMP),AdenosineMonophosphate(AMP),&GuanosineMonophosphate(GMP)

• Enhancebrainphospholipids&learning• Cognitex(w/w/oPregnenalone)


Glandulars-Foods & Supplements

•Brain•Hypothalamus•Pituitary•Adrenal•Thymus•Liver•Heart•Thyroid•Lung

TraditionalFoods•Tripe•Lung/Chanfaina•Thymus(sweetbread)•Heart•Liver•Tongue•Testicles•Kidneys•Blood

GLANDULAR BENEFIT DOSERANGE

Adrenal

HelpsthebodyrespondtostressSupportsimmunefunction

Supportsmetabolism&physiologicalfunctionofadrenalglands

Addressesfatigue,sugarmetabolism,andweightloss

100mgb.i.d.aor200mgt.i.d.a

AdrenalCortex Helpstosupportahealthystressresponse 250mg(1,t.i.d.)

Brain SupportsHPAaxis,depression 250mg(1-2,t.i.d.)

Glandular Supplementation


Hypothalamus SupportsHPAaxis,depression,TreatmentofTBI 500mg(1-3,t.i.d.)

Liver Supportsliverinalcohol&drugrecovery,detoxification,chemicalsensitivity 400mg(1-2,t.i.d.)

Pancreas

Supportdigestion  Maysupport&modulatetheimmunefunction  Maysupportbloodglucosewithinnormallimits  Supportspancreaticfunction&fatdigestion

400mg(1-2,t.i.d.)

Pituitary SupportHPAaxisdepression 250mg(1,b.i.d.)



Thymus Immunefunction 1,000mg(1-2,t.i.d.)

Thyroid Lowthyroidfunction 40mg(1-2,3x/day)



Myer’s Cocktail IV Supplements

•Magnesium•Calcium•VitaminsB12,B6,&C•UseforMigraines• Fatigue(chronicfatiguesyndrome)

• Fibromyalgia•Acutemusclespasm•Drug/alcoholrecovery

(Gaby, 2002); (Massey, 2007)


• Educatetheclient:roleofnutritionalsupplementationinwell-being• Prioritizecorenutrients

• Supplements/foods(e.g.probioticssupplementsorfreshfermentedfoodsorboth)

• Adjunctnutrientprotocol• Reviewassessment:matchspecificmodesofingestion (e.g.smoothies,capsules,andliquids,IVetc.)

• Applydrug/nutrientinteractionsdatabase• Considerconsultationw/prescribingorexpertclinician• Identifyobstacles/challengestoadherence

Protocol Design


Chronic Pain

• ChronicPainiscomorbidw/depression,similarapproachtotreatment• 5HTP5-hydroxytryptophan• D,L-phenylalanine• Foracutepain,useitat250mgevery2hours• Forchronicpainordepression,use500mg3timesaday

• Fishoil• Capsaicin(topical)• CompoundedKetoprofen,Ketamine,Capsaicin

• CBD-richtincture

Depression - Part 1NUTRIENTS DOSE

Complexvitamins&mineralswithL-methylfolate

Dosevariest.i.d.

Omega-3fishoil 1–3gramso.d.

Gammalinoleicacid(GLA)/borageoreveningprimroseoil

1,000mgo.d.

Freeaminoacids Dosevariesb.i.d.

Probiotics 100+billionCFUso.d.

VitaminD50,000IU(oral,1x/weekfor 8weeks)fordeficiency  2,000–4,000IUo.d.formaintenance


GlucoseTolerancefactor 1-2capsulest.i.d.

VitaminB6 10mgq.i.d.

Niacinamide Niacinamide

Methylcobalamin 1-2mcgo.d.

LithiumOrotate 50-150mgo.d.

Magnesium 400mg


5-HTP 50-100mgo.d.

Or/Tryptophan 50-100mg

L-Tyrosine 250-500mgb.i.d.

AdrenalGlandular 100-200mgt.i.d.

HypothalamusGlandular 500-1500mgb.i.d.

Melatonin 0.5-1mgo.d.

Lactium

OrthophosphoricAcid 30dropso.d.

Seasonal Affective Disorder - Part 1NUTRIENTS DOSE


Dosevariest.i.d.


Gammalinoleicacid(GLA)/BorageorEveningPrimroseOil

1,000mgo.d.



VitaminD50,000IU(oral,1x/weekfor8weeks)fordeficiency2,000–4,000IUo.d.formaintenance

Seasonal Affective Disorder - Part 2NUTRIENTS DOSE

GlucoseToleranceFactor 1-2capsulest.i.d.

VitaminB6 50-100mg.o.d.

Tryptophan 500mg.o.d.@night

Melatonin 0.5-1mgo.d.night

SAMe 400-600mgo.d.

Wheyprotein 2heapingtablespoonso.d.

Alcohol - Part 1NUTRIENTS DOSE


Dosevariest.i.d.

High-dosePhosphorylatedThiamineB-VitaminMineralComplex

1-2mcgo.d.

Omega-3FishOil(DHA/EPA) 1-2gmt.i.d

GammaLinoleicAcid(GLA)/BorageorEveningPrimroseOil

1000mgo.d.

FreeAminoAcids Dosevariesb.i.d.



VitaminD50,000IUor/

2000-5000IUo.d.

GlucoseToleranceFactor 1-2capsulest.i.d.

CDP-Choline 500mgb.i.d.

LiverGlandular 400mgt.i.d.

AdrenalGlandular 200mgt.i.d.

HypothalamusGlandular 500mgt.i.d.


Niacinamide 500mg

Magnesium 1-2capsulest.i.d.

Potassium 500mgb.i.d.

Lithiumorotate 400mgt.i.d.

5-HTP 200mgt.i.d.

Tryptophan 500mgt.i.d.

Melatonin 0.5–1mg

Alcohol - Part 4

NUTRIENTS DOSE

Phosphatidylcholine 800-1200mgb.i.d

SAMe 400mgb.i.d.

Lactium

(w/Anxiety)150-300mgo.d.

Anxiety - Part 1NUTRIENTS DOSE


Dosevariest.i.d.



1,000mgo.d.



VitaminD50,000IU(oral,1x/weekfor8weeks)fordeficiency2,000–5,000IUo.d.formaintenance


B6pyridoxalphosphate 50mgb.i.d.

B-12methylcobalamin 1,000mcgo.d.

Niacinamide 500mgb.i.d.

MagnesiumL-threonateorglycinate 100–400mg

AlphaGP-choline 600–1,000gramso.d.

Tryptophan 500mg


Lactium 150–450mgasneeded450–600mgforsleep

Orthophosphoricacid 30dropso.d.

Lithiumorotate(Depression&moodlability)

45mgo.d.(Shealy,2006)

Taurine(Highbloodpressureorgallbladderissues)

500–1,000mgt.i.d.

Glycinestrips(Acutepanic) 2g(sublingually)everyfewminutes(Prousky,2005)

Phenibut 250–500mgo.d.

Anxiety - Part 4

NUTRIENTS DOSE

Adrenalglandularstress 100mgb.i.d.or200mgt.i.d.

Stabilium(Garumarmoricum)(Useifcaseinallergy)

200–400mgo.d.

Oralmicronizedprogesterone(Prescriptiononlyformenopausalwomen)

50–100mgo.d.

Phosphatidylserine(Posttraumaticstressdisorder)

100mgt.i.d.

Sleep/Wake Disorders - Part 1NUTRIENTS DOSE


Dosevariest.i.d.



1,000mgo.d.



VitaminD50,000IU(oral,1x/weekfor 8weeks)fordeficiency  2,000–4,000IUo.d.formaintenance

Sleep/Wake Disorders - Part 2NUTRIENTS DOSE

Glucosetolerancefactor 1–2capsulest.i.d.

B-12methylcobalamin 1mgo.d.

Magnesiumthreonate 100–400mgo.d.

LithiumOrotate 1.5mgo.d.

Alpha-lipoicacid 200mgo.d.

Melatonin 0.5–1mgnight

Sleep/Wake Disorders - Part 3

NUTRIENTS DOSE

Lactium 450–600mgo.d.

5-HTP(optional) 25–100mgo.d.

Phenibut(optional) 250–500mgo.d.(reduceafter1monthtoeveryotherday)


• VitaminCtosaturation=10,000to20,000mgperday&more• 1000mgofvitaminCeveryhour.

• Saturation=singleepisodeofdiarrhea• Then⬇thedosageto1000mgevery4hours

• L-Glutamine(2000or3000mg)• ⬇physiologicalcravingsforalcohol.L-Glutamineisnaturallyproducedintheliver&kidneys

• Lecithin(2to4tablespoonsdaily)• Inositol&choline,relatedtotheB-complex• Lecithinalsohelpsmobilizefatsoutoftheliver

Dr.Abram Hoffer’s Protocol for Alcohol Recovery


• Chromium• 200-400mcgchromiumpicolinatedaily• Chromiumgreatly⬇carbohydratemis-metabolism,&greatlyhelpscontrolbloodsugarlevels

•Magnesium(400mg)&theantioxidantscarotene&d-alphatocopherol

Dr. Hoffer’s Protocol for Alcohol Recovery


Cognitive Impairment

• Trans-Fats=riskfactor• Intensivenutrientsupportdiet&exercisecanreversedecline&slowitinlaterstages• Lotsof(mis)diagnosesrelatedtomood&cognition

• Severaltypesofdecline• Noninflammatory-lowzinctypeAD• Mold


Alzheimers: Diabetes Type 3

• “Whatoccursintheheartoccursinthebrain”

•Inflammation(turmeric;hops&rosemarysuppressinflammatorycytokines)

•Blood/Oxygenflow(gingko,vinpocetine,VitaminE,HBOT)

•Insulinresistance(⬆adrenal/livereliminategrains/sugars)


Alzheimers: Diabetes Type 3

•Lossofbrainvolume(Brain,hypothlamus,CES,fats)•Impairedneurotransmitterfunction•Hormones(DHEA,estrogentestosterone)•Toxicaccumulations


Cognitive Function & Mood Elevation

•Coffee/BlackTeaw/MCT/RawButter;KetoDiet • Foods:Eggs,Liver •AminoAcids5-HTP(25-200mgs) •Glandulars:AdrenalbrainHypothalamus •Depression&Cognitionadd • Acetyl-Lcarnitine,GPCcholine(AlphaGlycerylphosphorylcholine)Gingko&Huperzine • (Note:somepeoplegetheadacheswithGingko)(notforuseduringpregnancy/lactation)


Cognitive Function Protocol

•Huperziaserrata/ChineseClubMoss•HuperzineA,(acetylcholinesteraseinhibitor)•⬆acetylcholine⬆memory⬆learning• 50-200mcg.Daily

•Bacopamonniera(Ayurvedicplant,Brahmi,waterhyssop)• 300-600mg(totalbacosidecontentat55%oftheextract)• Takewithfattymeal

• BensonS,DowneyLA,StoughC,etal.Anacute,double-blind,placebo-controlledcross-overstudyof320mgand640mgdosesofBacopamonnieri(CDRI08)onmultitaskingstressreactivityandmood.PhytotherRes.2014Apr;28(4):551-9.



•Acetyl-L-carnitine(ALCAR):crossesbloodbrainbarrier•⬆acetylcholine;⬆nervegrowthfactorinbrain,aproteinforlearning&memory.⬆metabolism

•⬆Enhancescellularenergy,⬇insulinresistance

• 250-500mg(am)• Potentiatesw/alphaGPC(glycero-phosphocholine)&RLipoicacid

• CombineHuperzine,Bacopa,R-Lipoicacid&ALCAR



• LithiumOrotate40mg/day

• RNA/DNA• Enhancecognition,memory,TBI,circulation

• Phosphytidalserine100mg/day• RegulatestheHPAaxis&supportsnervecelltransmission


Glandulars for Cognitive Function

•Brain •Hypothalamus&Pituitary •Adrenal •Liver(mood+anger)•Heart•Thyroid


Sundowning / Dementia

• Sundowning:agitation,confusion&anxietyinlateafternoon/evening•⬇productionofmelatonin• Deteriorationofsuprachiasmaticnucleus(SCN)•⬆2hrs.ofmorningbrightlight• Melatonin• CherryChamomilesmoothie• Pituitary/Hypothalamus500-2000mg• Cranial/Sacraltherapy&HandMassage• Melissaaromatherapy


• Andropause • LowT- Depression,irritability,lowlibido,bellygain

• PeriMenopause• LowP- Sleep,irritability,anxiety,foggy

• Menopause• LowP,E&T- Sleep,irritability,anxiety,depression,flashes,lowlibido,NT’sgodownwhenestrogengoesdown

Hormones


• Hypothyroid/Hyperthyroid• Cold,depressed/hot,anxious

• Testing&supplementation>referralstoprescribers • Women’sInternationalPharmacy• CompoundingPharmacies

Hormones


Bioidentical Hormones

Estrogen(s) estrone,estradiol,andestriolProgesterone,Testosterone,DHEA enhancingenergyandmusclestrengthPregnenolone autoimmunedisorders,chronicfatigue,anddepressionThyroidHydrocortisone Fatigue,ResearchsuggestsPTSDpreventionwithin1st3monthshttps://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75

https://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75https://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75https://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75https://www.mdedge.com/psychiatry/article/191164/depression/new-ptsd-prevention-guidelines-released/page/0/1?channel=75


Why Test?

•Testingincontext•Clientmaywantit• Itmayimproveadherencetoaplan•Testsmayconfirmwhatwebelieveorsuspect• Illuminatenuances


• VitaminD–depression,pain,immunefunction• TissueMineralAnalysis(excessmineralsheavymetalscancontributetomentalillness)https://www.traceelements.com/• 24hrdiurnalcortisol•Hormonepanels• Foodsensitivities•DigestivePanels• Specializedtesting:Walshprotocols,B-12,APOEgenetictesting

Laboratory Testing

https://www.traceelements.com/


•Homocysteine

•High-sensitivityC-reactiveprotein(CRP):norms,under0.55mg/Linmen&under1.0mg/Linwomen

•Fibrinogen:200–300mg/dL

Inflammatory Markers in Blood Tests


• Simplewaytotestfunctionaldeficiency,commonineatingdisorders

• Takeateaspoonfullofliquidzinc&youwillfindthatyouexperiencevaryingtastesbasedonyourbody’scurrentneeds•Deficientinzinc,theliquidwilltastelikewater•Adequatelevelsitwilltastebitter

Zinc Taste Test


• Drug–NutrientInteractionsVirtualDatabase• Usethisdatabasetoenteradrugorsupplement;receiveafullinteractionreportthatincludesnoticeofpotentialinteractions.Phone:800-931-17 http://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker

Databases

http://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checkerhttp://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker


Lab Testing

108

• TraceElements,Inc.•Hairanalysislaboratory.4501SunbeltDr.,Addison,TX75001  Ph:(800)824-2314.Fax:(972)248-4896 http://www.traceelements.com

•Diagnos-Tech’s,Inc.• Fortestingfoodallergies,adrenalstress,male/femalehormonepanels  Ph:(800)878-3787;Email:diagnos@diagnostechs.com; http://www.diagnostechs.com

http://www.traceelements.commailto:diagnos@diagnostechs.comhttp://www.diagnostechs.com


•GlutenandFoodAllergy/FoodSensitivityTesting• CyrexTMspecializesintestingforautoimmuneconditions https://www.cyrexlabs.com/  

• GreatPlainsLaboratory• Providesspecializedtesting,includingOrganicAcidstest,Gluten/Casein,VitaminD,aminoacidlevelstesting(urinaryandblood),urinary/serumpeptidetests,&zinctastetest http://www.greatplainslaboratory.com/home/eng/  Tests:https://www.greatplainslaboratory.com/select-a-test-2

Lab Testing

https://www.cyrexlabs.com/http://www.greatplainslaboratory.com/home/eng/https://www.greatplainslaboratory.com/select-a-test-2


• LifeExtension• Providesrequisitionsforclient-orderedbloodtests http://www.lifeextension.com/Vitamins-Supplements/Blood-Tests

• TheMediatorReleaseTest•Testsforfood&food-chemical-inducedinflammation  https://nowleap.com/the-patented-mediator-release-test-mrt/

Lab Testing

http://www.lifeextension.com/Vitamins-Supplements/Blood-Testshttp://www.lifeextension.com/Vitamins-Supplements/Blood-Testshttps://nowleap.com/the-patented-mediator-release-test-mrt/


• SpectraCell• Providesnutritionaltesting,includingMTHFR,telomeretesting,micronutrienttests(blood),andnutrientstatusforphysicians&theirclients.SpectraCellLabsalsoconductstelomeretestingviabloodsamplesubmission.  http://www.spectracell.com/

Lab Testing

http://www.spectracell.com/


Omega 3 Index

•MeasureslevelsofEPA/DHAinthebloodcell• Bloodspot/athometest• https://omegaquant.com/about/

• https://omegaquant.com/omega-3-calculator/• Calculateshowmuchdoseisneededfollowingtest

https://omegaquant.com/about/https://omegaquant.com/omega-3-calculator/


Supplements Sources

113

• BioticsResearchCorporation•QualityNutritionalproducts Ph:(800)636-6913;Fax:(800)863-9613; http://www.bioticsnw.com

•AllergyResearchGroup• Excellentsourceofvitamins,minerals,&glandulars.  http://www.allergyresearchgroup.com/

http://www.bioticsnw.com/http://www.allergyresearchgroup.com/


• CarlsonLabs• Excellentsourceforfishoil  http://www.carlsonlabs.com/

• IntegrativeTherapeutics• http://www.integrativepro.com

• FungiPerfecti• Providesmedicinalmushroomsupplementsandproducts.  FungiPerfectiLLC,POBox7634,Olympia,WA98507; Phone:(toll-freeinUS&Canada):800-780-9126(local):360-426-9292  info@fungi.com

Supplements Sources

http://www.carlsonlabs.com/http://www.integrativepro.com/mailto:info@fungi.com


•NordicNaturals•High-qualityfishoilcombinationsforallages Website:www.nordicnaturals.com

• StandardProcess• Excellentsourceofchlorophyll&glandulars Website:www.standardprocess.com/home

Supplements Sources

http://www.nordicnaturals.com/http://www.standardprocess.com/home


• LifeExtension• Providesnutritionalinformation,products,&services.  http://www.lef.org/

• LifeExtensionMagazine• AmonthlypublicationoftheLifeExtensionFoundationontopicsofnutrition,hormones,&antiagingsupplements.  http://www.lifeextension.com/magazine

• ThorneMetabolicNutrition• Qualitynutritionalsupplements.  https://www.thorne.com/

Supplements Sources & Information

http://www.lef.org/http://www.lifeextension.com/magazinehttps://www.thorne.com/


Databases

• RxISK• Free&independentwebsitewherepatients,doctors,&pharmacistscanresearchprescriptiondrugs&easilyreportadrugsideeffect https://www.rxisk.org

•NutritionData• Detailednutritioninformation,plusuniqueanalysistoolsthattellyoumoreabouthowfoodsaffectyourhealth&makeiteasiertochoosehealthyfoods http://nutritiondata.self.com/

https://www.rxisk.orghttp://nutritiondata.self.com/


• FullScript:upto35%offhighgradesupplements•Signuphereandadonationismadetothecharity• CWIS“NutrientsforNatives”program

•https://fullscript.com/practitioners/dr-leslie-korn

Distributors

https://fullscript.com/practitioners/dr-leslie-kornhttps://fullscript.com/practitioners/dr-leslie-korn


• BastyrUniversityNutritionPrograms

• http://www.bastyr.edu/academics/areas-study/study-nutrition

•HealthCoachTrainingProgram

• http://www.integrativenutrition.com/

Nutritional Therapies Training

http://www.bastyr.edu/academics/areas-study/study-nutritionhttp://www.bastyr.edu/academics/areas-study/study-nutritionhttp://www.integrativenutrition.com/http://www.integrativenutrition.com/


• NationalAssociationofNutritionProfessionals(NANP)https://www.nanp.org/list-of-schools

• NutritionalTherapyPractitionerProgram• https://www.nutritionaltherapy.com

Nutritional Therapies Training

https://www.nanp.org/list-of-schoolshttps://www.nanp.org/list-of-schoolshttps://www.nutritionaltherapy.comhttps://www.nutritionaltherapy.com


•AmericanNutritionAssociation•  https://theana.org/advocate

•Weston-PriceFoundation• http://www.westonaprice.org/

Organizations

https://theana.org/advocatehttps://theana.org/advocatehttp://www.westonaprice.org/http://www.westonaprice.org/


• Ethical&Legalissuesofuseofnutritionalsupplements• Goals&Dosingofsupplements• Contraindications&Drug/NutrientInteractions• CoreNutrientsforMentalHealth• Water&FatSolubleVitamins;Minerals• Aminoacids&Neurotransmitters• ProtocolsofSpecialNutrients,Vitamins,Minerals&Glandulars• IntegrateBioidenticalHormonesforenhancedefficacy• DevelopingProtocols

Summary

Thank you!drlesliekorn.com lekorn@cwis.org
http://drlesliekorn.com/mailto:lekorn@cwis.org?subject=

Nutritional Therapies for Mental Health - Dr. Leslie Korn...GLANDULAR BENEFIT DOSE RANGE Adrenal...

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