Improving the quality of life with

Medical Grade Platform, Personal Monitoring and Alarming System

Interdisciplinary Expert Team

2

Gadi Kan-Tor Co-Founder & Co-CEO

Yoav Kan-Tor Co-Founder & Developer

Shy Hefetz Co-Founder & CTO

Chanan London Co-CEO

Roy Talman R&D Engineer

Prof’ Moshe Philip,

A World Leading

Diabetes Expert

Introducing Hypo-Sense

Night-Sense first product:

A "watch-like“, noninvasive, medical device,

Detects Onset Sleep Hypoglycemia episode,

continuously and autonomously

using the body’s physiological alarms

The Hypoglycemia and the Need

Possible Causes

Nutrition

Activity

New drug

Disease

Insulin

Previous Hypo events

After Effect

Coma, Death (2%-10% of Type 1)

Damages to internal organs

Increased risk for future events

The Episode

Duration 0.5H - 2H and longer

Physiological & Neurological Symptoms

Severe Treatment costs ~ $4,000

The Need in Numbers

World Wide Insulin Users

100M Total

5M Will die

Severe Hypo Episodes per Day

160K

100K During Sleep

Severe Hypo Events p/Patient p/year

Type1/Type2

1.3/0.4

0.7/0.2 During Sleep

5

Sleeping diabetic patient at home

Docking

station

Cloud based data storage and

a learning module of the system

Internet

connection

Emergency

centers

Clinics and

doctors

Caregivers,

Parents or

family members

The Hypo-Sense is placed

on the patient’s wrist

The Solution – The Night-Sense Alert System

Local

Alert

Bluetooth Smart

Alert Options

The Hypo-Sense

A wristband medical device:

A designated set of

co-located sensors,

Proprietary algorithm,

machine learning,

personally calibrated

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Physiological sensor Consumable unit

Patient interface

The Hypo-Sense Detection & Alert Process

• Heart rate, HRV

• Respiratory

• GSR (Sweat levels and stress)

• Motion (tremors, seizures)

• Muscle activity

• Skin & ambient temp

• Machine learning Detection Algorithm

• Personally calibrated

• Local Alert

• Wireless Alert

• Data upload to Cloud

8

Physiological

responses to

hypoglycemia

Detecting

Hypoglycemic

episode

Alert

Hypo-Sense Key Benefits

• Non-Invasive

• Medical Grade

• Continuous

• Cost effective

9

All Around Value Proposition

Patients & families

Hypo alert

Sense of security

Preemptive

Doctors & Care Givers

Untroubled sleep

Recording of events

Treatment flexibility

Insurers

Prevents hospitalizations

Improved service

Treatment costs reduction

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Marketing Positioning

Addressing trends within rapidly

growing markets

Digital Health

Home Medical care

Preventive Care

Wearable technologies

IoT

Big Data

USA “Obama Care” The Patient Protection and

Affordable Care Act

How is it solved today?

12

Check Blood Glucose Level

• SMBG: Self-Monitoring Blood Glucose devices –

Pricking Device, Patient intervention

• CGMs: Continuous Glucose Monitoring –

Expensive, invasive and highly intrusive

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Hypo-Sense - First clinical study

• Performed in the Schneider medical center, supervised by Prof. Moshe Philip

• Protocol approved by Hospital Ethics committee, ministry of health and registered in the NIH

• Successfully completed the protocol on all sessions, measured the parameters from the wrist

• Post session analysis identified symptoms of hypoglycemia episodes

• System Patent - PCT (10/2013), US 4/2015, EU 5/2015

“COMFORTABLE AND PERSONALIZED MONITORING DEVICE, SYSTEM,

AND METHOD FOR DETECTING PHYSIOLOGICAL HEALTH RISKS”

• Unique view on hypoglycemia

1st time ever that the specific combination of physiological

parameters were measured during hypoglycemia.

• Additional patents based on innovative results from

the clinical study

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Intellectual Property

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Thank you

Thanks for listening!