Empower 3 Feature Release 2New Features

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Mr. Jose Wilson CastroLatin America Informatics Director

– Branding Refresh

– Technology updates

– Feature Updates

o ICH Impurity Processing

o Toolkit

o LDAP Enhancements

o Method Validation Manager

Agenda : Empower 3 FR2

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o Method Validation Manager

o Enhance Data Review

o QuickStart

o Usability enhancements

o Empower Analytics

o Empower Mobile

o Sample Weight Importer

o Qualification Updates

– Questions

What Sets Empower 3 Apart?

Adaptable ‘switch-on’ approach:

� Compliance

� System Suitability

� GPC & SEC

� Dissolution

� Chemical Structures

� Multi Vendor LC Control

� Multi Vendor GC Control

� Photodiode Array

� MS

� ACQUITY H Class

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� Chemical Structures

� Toolkit

� ApexTrack Integration

� Custom Calculations

� Custom Reporting

� Sample Weight Importer

� Empower Mobile

� Business Analytics

� ACQUITY H Class

� Waters SFC

� Beckman CE Control

� Enterprise Data Manager

� Method Validation Manager

� Fusion Method Development

� Waters Data Converter 2

Branding Refresh

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� Icons

� Backgrounds

� UI Interface

� Installation Screens

Conceptual Empower 3 Pro Interface

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Proposed Empower 3 FR2 Architecture

� Technology:

– Oracle 11g(11.2.0.2 Patch set 15) R2 Database (64-bit) patch set 17

– Windows 2008 R2 Server Standard or Enterprise (64-bit)

– Windows 7 Professional & Enterprise Operating System (64-bit)

– Windows XP Operating System (32-bit) (clients and LAC/Es)

– Citrix XenApp Server 6.0 /6.5/6.8 running on Windows Server 2008 R2

Standard or Enterprise, 64-bit

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Standard or Enterprise, 64-bit

– VMWARE vSphere 5.0*

– Red Hat Linux Enterprise 6.2

� Provide a New type of group peak, Impurity Group, used to calculate Total Impurities and other user defined impurity summaries.

� Total Impurities (automatically created group peak).

� Unidentified Impurity (default impurity component type).

� Maximum Impurity (new Boolean peak field).

� PCS 42069 – Add the ability to set an acceptance criteria of ‘no impurity peak found’.

ICH Impurity Processing

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found’.

� the user can select whether the total impurities determined should be the sum of Amount, Concentration or Corrected Area % or peak custom field

� PCS 41002 – Sum total of degradation products

� The user can specify which component types should be summed (some impurities will be known and hence will use a user-defined component type, other impurities could be quantitated by default and hence be automatically defined as Unnamed Impurities)

ICH Impurity Processing

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Usability enhancements-Review

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� System suitability settings should be included in the "new processing method"

wizard

Enhanced Data ReviewConceptual New Result Audit Viewer

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� New application which will be

launched from Configuration

Manager

� Available for Personal,

Workgroup, Enterprise Users

� Privileged to Run and edit admin

section.

Empower 3Basic Business Analytics

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section.

� Ability to export

Empower 3Basic Business Analytics

� Display General Environment status of logged inusers including:

– The number Chromatographic Systems both Online and Offline

– The number of Empower Raw Data Servers, Citrix Servers, Clients, LAC/E32

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Servers, Citrix Servers, Clients, LAC/E32

– The number of Projects including Normal, Locked, Process Only, Read Only, Validation Template (?), Validation Working (?) and Total

– The User Status including the number of Active, Disabled and Removed as well as the number of Groups.

Empower 3Basic Business Analytics

� System Usage

– Total number of Injections by system

– Total number of Injections by system by month

Total number of Sample Sets by system

– Total number of Sample Sets by system by month

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Empower 3Basic Business Analytics

� Project Usage

– Total number of Injections by project

– Total number of Results by project

– Total number of Results by project by month

– Total number of Sample Sets by project

– Total number of Sample Sets by project by month

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– Total number of Sample Sets by project by month

� Message Center

– Message Center Overview

– Which systems are causing which

errors

– Which users are causing which

errors

Empower 3Basic Business Analytics

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Empower 3Basic Business Analytics

� User Analysis: There will be a place to enable or disable this

requirement based on a customer’s/country requirements.

– Total number of Injections by user

– Total number of Results by user

– Total number of Results by user by month

– Total number of Sample Sets by user

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– Total number of Sample Sets by user by month

� Methods Analysis

– Manual integration analysis – customers want this to be manual

integration tracking- Amount of manual integration that is

occurring per project and per user

– Amount of reprocessing that is occurring per project and per user.

UPLC PotentialUPLC Potential

� Top 5 HPLC to UPLC Potential

Empower 3Basic Business Analytics

� Top 5 Projects with UPLC Potential

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Empower 3 Mobile

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Empower 3 Mobile

� Waters Empower Mobile provides mobile access (via phone and tablet) to a subset of core Empower functionality.

� Functionality will be targeted for specific users, tasks and workflows

Instrument

monitoring

User / group

administrationWorkflow and

report signoff

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Pricing

� Empower Mobile will be free

– It will be an Empower option that can be installed

– It will be installed on top of an Empower client.

� Empower Mobile will only be

– installed on Empower 3 FR2

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– installed on Empower 3 FR2

– Available on Empower Client -> Server

� Users of Empower Mobile must be Empower users

– Same credentials, permissions and audit trails

The Technology

� Empower mobile is a HTML 5 based application

– Its runs inside the browser of your mobile device

– It is not installed on the mobile devices

o Web shortcuts look similar to apps

� HTML means we support browsers not devices

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� HTML means we support browsers not devices

– We will test the default browsers using key devices

� We do not IQ the mobile devices, only the server

– The server IQ can (optionally) be run following Empower mobile

server install

Architecture

IIS

Empower Mobile

Empower Client

VPN / Inside Firewall

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Empower Server

Fast

Connection

General Look and Feel

Back button

Title [Details]

Top level navigation menu• Systems• Results• Administration

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Refresh button

‘Overflow’ menu

ConfigurationHelp CommunitySign out

Current information or records

Top

Empower Sample Weight Importer (SWI)

Overview

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Solution Overview

� Starts from inside Empower, no additional login required.

Import weights from balances directly into Empower

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� Interacts with an Empower Sample Set Method

– Map weights to sample and component fields.

� Import weights to existing and running sample set methods

� Keeps a complete audit trail of all weights acquired for FAT

projects

Overview of Traditional Approach

� Traditional manual process

– Error Prone

o Easy to make Transcription Errors

o Possible to lose weights

– Traceability

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– Traceability

o Additional meta data may be lost

• Balance, date time, analyst

o No formal audit trail

o The manual process is open to manipulation

– Speed

o Writing and manually entering the weights can be a time

consuming process.

SWI High Level Workflow

� User logs into Empower

– Open Empower Run Samples / Project Window

– Select ‘Sample Weight Importer’ from custom menu

� Empower Sample Weight Importer starts

– Select balance from dropdown list

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– Select balance from dropdown list

– Select Empower sample set method

– Acquires weights and maps to samples/components

– Save the changes to the sample set method.

Mapping weights to a sample set method

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Modifying a running sample set method

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Modifying a running sample set method

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Client PC

Basic Solution Architecture

Direct Cable Connection

Ethernet Conversion(if required by balance)

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Empower

Sample Weight Importer

Empower Toolkit

SDS

Advanced Solution Architecture

Empower Network

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Ethernet Conversion(if required by balance)

Tibbo Device to connecting a balance to network

http://tibbo.com/soi/tdst.html

Example Custom field configuration

Required CustomField

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The Error for a missing customfield

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Designed for the EnterpriseDesigned for the Enterprise

Waters License Activation Center – Web

Used to activate and export licenses selected from order number

User provides contact information

User selects desired software serial numbers

License activation file is

created for download

User executes License Wizard

Software Licensing

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User executes License Wizard

to activate license on computer

Splitable user licenses

Multi database user license

Lower Total Cost of Ownership

Rapid Deployment

Silent push installs for E3 and ICS

Virtualization with VMWare

Thin Client Computing with Citrix

Designed for the Enterprise

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High Availability

Maximize uptime with Oracle RAC & Data Guard

Virtualization with VMWare

Thin Client Computing with Citrix

Enhanced WAN Compatibility

Improved software performance

Technology:

Oracle 11G R2 Database (64 bit)

Windows 2008 R2 Server Enterprise (64-bit)

Windows 7 Professional Operating System (64-bit)

Windows XP Operating System (32-bit) (clients and LAC/Es)

Citrix XenApp Server 6.0 running on Windows Server 2008

Empower 3 Architecture

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Citrix XenApp Server 6.0 running on Windows Server 2008

R2 Enterprise (64-bit)

Web based electronic licensing

Push installations

Empower 3 Client software

Instrument control software

Common CDS Platform

Europe USA

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AsiaLatin

America

Designed for the Enterprise

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Personal Workgroup Enterprise

Client-Server Environment

DatabaseServer

Raw DataServer

EmpowerClient

EmpowerClient

EmpowerClient

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ChromatographicSystems

AcquisitionServer

Citrix Environment

DatabaseServer

Raw DataServer

CitrixServer

CitrixServer

CitrixServer

Citrix Client

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ChromatographicSystems

AcquisitionServer

Oracle Real Application Clusters (RAC)

Server 1 Server 2 Server 3 Server N

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CPUCPU CPUCPU CPUCPU CPUCPU CPUCPU CPUCPU CPUCPU CPUCPU…

Mirrored Sites

SYNC/ASYNC

Primary SitePrimary Site Active Standby SiteActive Standby Site

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Broker

PrimaryDatabase

Physical or Logical Standby Database

Virtualization

� Rapid deployment

� Disaster recovery

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� Disaster recovery

� Validation benefit

� High availability

� Server consolidation

� Scalability

Authentication setting on User Account tab

sets Local or LDAP Authentication

Disables:

Enforce Unique User Passwords

Password Expiration

Enterprise Authentication Using Active Directory (LDAP)

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Limit # of Entry Attempts

Minimum Password Length

Enables LDAP Domain Manager

Allows you to define multiple

Active Directory Domains for

authentication

Questions

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