State of the art

Introduction to Neuro-Immunology

Dr. Abdallah El-Sayed AllamMSc of Physical Medicine, Rheumatology and Rehabilitation .

Faculty of Medicine. Tanta University. EgyptMSK US fellowship. National Taiwan University. Taiwan

Immune surveillance of CNS &Clinical Application

Clinical Application

Why do we need a control?

Concept of Metasystem

Immunologic Homunculus

Immunologic Homunculus

Concept of Metasystem

Why do we need a control?

Clinical Application

Immune surveillance of CNS

Clinical Application

• Nervous system controls Immune system via centers,

sympathetic, parasympathetic as well as endocrine

system

• T Lymphocytes trafficking is very important for immune

response.• BBB and peripheral immune reactions for the brain are

important in protection of the brain against many

immune reactions.• T Lymphocytes trafficking is a therapeutic target as MS

• Inflammatory reflex attenuates the inflammatory

response. Clinical application eg stroke and RhA

Thank You

Thank You