Post on 16-Jan-2015
description
CEREBRAL ARTERIOVENOUS MALFORMATION
(AVM)
Randy Reichenfeld
WHAT IS AN AVM?
An AVM is an abnormal connection between the arteries and veins.
Consist of feeding arteries, nidus, and draining veins.
AVM
They can occur anywhere but mostly in the brain and the spine.
Can by asymptomatic and never detected. Symptomatic AVMs may need treatment. Hinders gas exchange On occasion a patient with AVM can become
aware of ‘whooshing’ sounds and may cause loss of sleep and psychological distress.
Can rupture/hemorrhage causing brain damage or death (2-4% per year)
AVM- CAUSE
Unknown Congenital
Symptoms at any age May or may not be hereditary Occur in males and females of all racial or
ethnic backgrounds at roughly equal rates. 300,000 Americans
12% symptomatic 1% die of direct result
10% mortality associated with the first hemorrhage, and up to 30% mortality associated with each rebleed
SYMPTOMS
Depends on location in brain Headache Epilepsy Confusion Tinnitus Dizziness Blurred vision numbness (any part of body)
DIAGNOSING
CT/CTA Hemorrhage in the 4th
ventricle Difficult on non
contrast CT. Enlarged draining veins
may be seen. With contrast is much
easier but exact anatomy may still be unclear so DSA is still necessary
DSA (DIGITAL SUBTRACTION ANGIOGRAPHY)
-Gold standard-Able to identify the exact number of feeding vessels and pattern of drainage.
DIAGNOSING- MRI
-Right thalamic AVM
-Flow voids (black) evident on T2
-Hemorrhage and edema may also be detected using MRI
MRA
-Useful to subtract the hematoma components when a hemorrhaged AVM needs to be imaged
SPETZLER-MARTIN AVM GRADING SYSTEM
Used to evaluate the surgical risks AVM given a rating of 1-5 Based on
Size small (<3cm) = 1 medium (3 - 6cm) = 2 large (> 6cm) = 3
Eloquence (degree of functional importance) non-eloquent = 0 eloquent = 1
Venous drainage superficial only = 0 deep = 1
TREATMENT
Can either be Surgical Non surgical
Stereotactic Radiosurgery Endovascular Therapy
TREATMENT- SURGERY
Spetlzer Martin Grades 1-3 Complete resection of AVM in one operation Advantages
immediate elimination of hemorrhage and rehemorrhage risk, and improvement in seizure control
Risks Spetzler-Martin Grades 1-3 AVMs carries a 1-10%
chance (respectively) of significant neurological complication
TREATMENT- SURGERY
1)T2 MRI shows small AVM in frontal lobe2)Craniotomy3) Dura exposed4)Dura removed, showing arachnoid
1)neuronavigation image in real-time2) Surface feature of AVM3) Resection begins4) Resected AVM
TREATMENT- STEREOTACTIC RADIOSURGERY
Uses GammaKnife or Linear Accelerator (Linac), to deliver a focused beam of radiation to the nidus of the AVM.
Used for Deep AVMs or Spetlzer Martin grade 3+ Advantages
Painless, well tolerated by most patients Risks
secondary tumors impairment of brain function cystic radiation necrosis
average 2-3 years for the AVM to be cured significantly higher rate of rebleeding among AVMs
treated with SRS compared with AVMs treated surgically.
TREATMENT-ENDOVASCULAR
involves placement of metallic microcoil or glue like substance in the lumen of arteries feeding the AVM in order to slow the flow of blood, encouraging AVM feeder arteries to clot off.
rarely cures an AVM Helpful supportive measure for
future open surgery or stereotactic radiosurgery.
risk of death or significant neurological disability is about 4-5%
CASE STUDY
Andrea is a 41-year-old female with a medical history of Klippel-Trenaunay Syndrome (an abnormality associated with enlarged blood vessels in an extremity) and for Andrea her left leg is affected. She woke numbness and heaviness in her leg and went to the Emergency Department.
CASE STUDY
T2 weighted MRI shows an AVM in the left temporal lobe.
CASE STUDY
DSA confirms AVM
Andrea’s doctors agree the best form of treatment is surgical removal.
CASE STUDY
Post operative DSA confirms the complete removal of the AVM