Mediterranean School of OncologyCINBO

Consorzio Interuniversitario Nazionale pre la Bioncologia

Individuazione del bersaglio molecolareIndividuazione del bersaglio molecolare

Gene profiling

BINOMIO MOLECOLARE DIAGNOSTICO E TERAPEUTICO: STATO DELL’ARTE E PROSPETTIVE FUTURE

Nuovi bersagli molecolari e loro applicazioni

Bersagli molecolari selezionatiBersagli molecolari selezionati: consolidati e nuoviconsolidati e nuovi

Apoptosi, TRAILFattori di crescita e loro recettoriProteasomaAngiogenesiRegolazione trascrizionale ed epigenetica come bersaglio terapeuticoMicro RNA: the New World

Applicazioni nei tumori solidi e ematologiciApplicazioni nei tumori solidi e ematologici

Mammella, Tratto GE, Polmone, Apparato Genitale Femminile, Mieloma, APL

Gene Profiling in the Prognostic Evaluation

Lung

Breast

Ovary

Receptor-type TK signalling

Survival Growth Angiogenesis

Block of VEGF or EGFR in Cancer Treatment

Science Aug 2004

Science June 2004

Mutations of EGFR are pathogenetic and Mutations of EGFR are pathogenetic and treatment sensitizingtreatment sensitizing

From Kaufmann & Vaux, Oncogene, 22: 7414, 2003

Alterations of apoptotic pathways in human cancerAlterations of apoptotic pathways in human cancer

NF-kB: a fundamental role in cancer pathogenesis, a target in cancer therapy

Cytoplasmic nuclear transitionCytoplasmic nuclear transition

A proteasome based regulation

Proteasome inhibitors: Velcade(bortezomib)

The proteasome as a target of cancer therapyThe proteasome as a target of cancer therapy

Retinoic acid induces differentiation of APL blastsRetinoic acid induces differentiation of APL blastsExpressing PML/RARExpressing PML/RAR

1010-6-6 M M(or RA 10-9 M)

1983

Altered gene methylation in cancer

1989

Hypermethylation of a tumor suppressor gene in cancer

Chromatin remodelling by deacetylation in human cancer

1998

Clinical trials with demethylating and deacetylase inhibiting agents

2003

Altered histone methylation in human cancer

2002

Landmarks in cancer epigeneticsLandmarks in cancer epigenetics

Many HDAC InhibitorsMany HDAC Inhibitorsare entering are entering clinical trialsclinical trials

Chromatin remodelling in gene regulationChromatin remodelling in gene regulation

Micro-RNA: the future?