Post on 08-Feb-2017
Ministry of Health Care of UkraineSHEI “Ivano-Frankivsk National Medical University”
The Chair of Organization and Economics in Pharmacy and Drug Technology
Medicated chewing gum, a novel drug delivery system
Prepared by: Anyadiegwu EbukaScientific coordinator: A. Sinichenko assistant the Chair of OEPh and Drug Technology
Relevance: oral route of application of medications is the most preferred among patients and doctors through several advantages, including the most important is its simplicity, besides it can provide a faster onset of action. These dosage forms deliver the drug to the target through a local or systemic delivery of the drug in the mouth. For the drugs having significant buccal absorption, dosage forms such as chewable tablets and chewing gums permit more rapid therapeutic action as compared to per-oral dosage forms. Besides chewable tablets and chewing gums have been very well received by the parents for their use in children with full dentition.
The purpose of the work: to characterize medicated chewing gum (MCG) like drug delivery system, to research perspectives of application and developing drugs in a forms of chewing gum, place and value of MCG at the pharmaceutical market.
Medicated chewing gum- it is solid dosing medicinal form like a pillow or plates with a base consisting mainly
of gum, which is intended for chewing. It contains one or more
active substances that are released during
chewing by providing local or systemic action
after absorption through the buccal
mucosa and gastrointestinal tract.
Chewing gum has several advantages:1. Increased rate of effectiveness rather than other oral delivery systems.2. Removal of gum at any time.3. Reduced risk of overdosing while it's whole swallowed.4. Requiring no water to drink.5. Protection of the susceptible drugs contained from chemical or enzymatic attack in gastrointestinal tract.6. Both systemic and local drug delivery.7. High acceptance by children and teenagers.8. Good for rapid delivery.9. Fewer side effects.10. Good stability.11. Possibility of prolonging the release of active substances.12. Drugs come to the gastrointestinal tract in dissolved or suspended form in the saliva, in bioavailable form.13. Reduced hypoglycemic shocks in people taking anti-diabetic drugs.14. Stimulating alertness through increased blood flow to brain.15. Help reduce food cravings.
By aim of application
chewing gums divided for:
Dental caries Systemic therapy:Therapeutic use Drug
Treatment of motion sickness Dimenhydrinate hydrochloride,Diphenhydramine hydrochloride,Ginger
Smoking cessation Nicotine
Pain reliever Aspirin, lobeline, silver acetate
Anti-plaque, and gingivitis, preventing of dental caries an tooth decay
Xylitol, chlorhexidine
Oral antifungal Miconazole
Treatment of otitis media Xylitol
Alertness and CNS stimulant Caffeine
Antioxidant Green tea
Anti-nausea and anti-emetic, effective in GI problems
Ginger
At this slide present the percentage of people who chew gum by country:
Countries manufacturers of medical chewing gum
Medical chewing gum by the application
Composition of MCG include:
Gum base
Elastomers
Plasticizers
Adjuvants Antioxidants
Sweeteners
Coloring agents
Flavoring Agents
Gum base 15-30%
The particles of active ingredients should be less than 100 microns
The active substance can be a part of nuclei and shell
Manufacturing process of MCG include next stages:Softening or melting
components of gum base Administration of sweeteners
and syrups, active ingredients and other
excipientsThe gum is then sent through a series of rollers that forms
into a thin wide ribbon. Tow of gum is cut into equal
parts and transfer into a room with controlled
temperature.The resulting gum for a few
days ready to a coating shell .
Quality control for MCG conduct by the next indicators:
Dissolution test
Microbiological purity
Uniformity of
content
Uniformity of mass
Uniformity of
dosing units
CONCLUSIONSResearch of pharmaceutical market showed that currently
chewing gum is quite common in the population but medicated chewing gum has not found significant distribution
due to its small nomenclature. According to the results of research among presented at
pharmaceutical market MCG is dominated dental due to their wide range.
So considering all advantages of these medical form actual questions of modern medicine and pharmacy is to develop medicines in the form of MCG, with the purpose to expand nomenclature as this medicinal form is an alternative for patients who have difficulty swallowing exercise, or for
children who are not able to swallow the medicine.
THANKS FOR YOUR ATTENTION!
Prepared by: Anyadiegwu Ebuka Scientific coordinator: A. Sinichenko
Ministry of Health Care of UkraineSHEI “Ivano-Frankivsk National Medical University”
The Chair of Organization and Economics in Pharmacy and Drug Technology