Post on 15-Jan-2016
MCMP 441 DOR 101 PharmacologyDOR 101 Pharmacology
Abdelkader Ashour, Ph.D.Abdelkader Ashour, Ph.D.
33rdrd Lecture Lecture
MCMP 441
Autonomic Nervous SystemAutonomic Nervous System
MCMP 407
Organization of The Nervous SystemOrganization of The Nervous System
Central Nervous System: Brain and spinal cord
Peripheral Nervous System
Somatic Nervous SystemAutonomic Nervous System
Sympathetic Parasympathetic
Efferent DivisionAfferent Division
MCMP 407 Efferent division of the peripheral nervous system
MCMP 407
MCMP 407 Some anatomic and neurotransmitter features of Some anatomic and neurotransmitter features of autonomic and somatic motor nervesautonomic and somatic motor nerves
MCMP 407
Mimic or block the effects of the two primary neurotransmitters, Acetylcholine and Norepinephrine/Epinephrine
Drugs that mimic neurotransmitters are referred to as “receptor agonists” These drugs activate receptors
Drugs that block neurotransmitters are referred to as “receptor antagonists” These drugs block the endogenous neurotransmitters from
activating receptors
How do drugs influence the ANS?How do drugs influence the ANS?
MCMP 407
Parasympathetic nervous systemMimic acetylcholine = cholinergic = muscarinic agonists = parasympathomimetic
Block acetylcholine = anticholinergic = muscarinic antagonist = parasympatholytic
Sympathetic nervous systemMimic norepinephrine = adrenergic = adrenergic agonist = sympathomimetic
Block norepinephrine = antiadrenergic = adrenergic antagonist = sympatholytic
Classification of drugs affecting the ANSClassification of drugs affecting the ANS