Post on 17-Jan-2015
description
Lowering the Lowering the Histamine BurdenHistamine Burden
Methods we used to lower our young son’s histamine burden,
to reduce the frequency and intensity of dangerous and painful
histamine mediated reactions.
The Mastocytosis Society Annual ConferenceOctober 2012
Copyright Tiffany Blackden 2012 All Rights Reserved
Copyright Tiffany Blackden 2012 All Rights Reserved
Max’s Daily MCAD Max’s Daily MCAD SymptomsSymptoms
Hives, dermatographia, flushing, swelling, stomach aches, headaches, leg pain, itching, anaphylaxis from:Food (too many to name!)FrictionHeatColdChange in tempAnimalsChemicalsSynthetic FabricsSkin Contact With Plants/GrassEtc…???
Copyright Tiffany Blackden 2012 All Rights Reserved
A few of his A few of his reactions:reactions:
Blisters on both lower legs after consuming olive oil.
Rolled around on synthetic rug…
taken after the hives calmed down a bit.
Really angry reaction from playing with a scratchy rope. This was after it was calm, we nearly went to the hospital, it covered a lot of his torso and most of his arm.
Copyright Tiffany Blackden 2012 All Rights Reserved
Max’s Health Team:Max’s Health Team:
Naturopathic DoctorsNationally Certified NutritionistsAcupuncturist - BioSet PractitionerChinese Medicine PractitionerOsteopathic DoctorChiropractorMD HomeopathBiomedical MDHis Mommy, Daddy and Sister, Ellie
Copyright Tiffany Blackden 2012 All Rights Reserved
What’s in a mast cell? Preformed mediators :
(from granules)-Serine proteases-Tryptase-Histamine-Serotonin-Proteoglycans-mainly heparin
Newly formed Lipid Mediators: (eicosanoids)-Thromboxane-Prostoglandins-Leukotreines-Platelet Activating Factor-Cytokines
Today we are focusing on HISTAMINE…Copyright Tiffany Blackden 2012 All Rights Reserved
Art by: Angela Canada Hopkinshttp://www.canadahopkins.com/
Histamine is a protective part Histamine is a protective part of our body’s natural of our body’s natural responses…responses…
Local Immune Response for Injury
Protective Mechanism in ‘Boundary’ Tissues
Regulates Smooth Muscle Contraction
Neurotransmitter
Copyright Tiffany Blackden 2012 All Rights Reserved
Histamine Affects Histamine Affects EveryEvery System of the Body System of the Body
NeurologicalCardiovascularMusculoskeletalGastrointestinalReproductiveRespiratoryCutaneous
It is produced in mast cells, basophils, platelets, neutrophils and some neurons…and stored intracellularly, then released when stimulated.
Copyright Tiffany Blackden 2012 All Rights Reserved
Histamine Receptors:Histamine Receptors:H1: Smooth Muscle, Endothelium, Central
Nervous System Tissue
H2: Gastrointestinal, Vascular Smooth Muscle Tissue
H3: Central Nervous System and Some Peripheral Nervous System
H4 (Just discovered in 2000): Bone Marrow, Basophils, Thymus, Small Intestine, Spleen, Colon
Copyright Tiffany Blackden 2012 All Rights Reserved
Dtsch Arztebl 2006; 103(51–52):A 3477–83.
Copyright Tiffany Blackden 2012 All Rights Reserved
Histamine Histamine Burden is Burden is cumulative over cumulative over the course of a the course of a day (sometimes day (sometimes more, if the more, if the burden is high).burden is high).
Control what you Control what you CAN, to keep the CAN, to keep the cup from cup from overflowing with overflowing with all the factors all the factors not in your not in your control.control.
Copyright Tiffany Blackden 2012 All Rights Reserved
Histamine Overload…Histamine Overload…
Histamine for Digestion
PineappleSodium Benzoate in Soda
Cat Dander
Ragweed
Hot Day
Chicken Leftover in Fridge
Copyright Tiffany Blackden 2012 All Rights Reserved
Sources of Histamine:Sources of Histamine:
Normal Metabolic Function Throughout Body
Dietary Histamine Foods That Release Histamine From
Mast CellsIgE (Allergy) Mast Cell Degranulation Non-IgE (Trigger)Mast Cell
DegranulationBacteria
Copyright Tiffany Blackden 2012 All Rights Reserved
Avoiding High Histamine Avoiding High Histamine Pitfalls:Pitfalls:
Fermented FoodsCured FoodsDyesPreservatives/AdditivesSulphitesRefrigerated Leftovers (freeze them)AlcoholHigh Histamine FoodsHistamine Releasing FoodsDAO Inhibiting Chemicals
Copyright Tiffany Blackden 2012 All Rights Reserved
How Does How Does HistamineHistamine
* *EXIT*EXIT* Our Bodies?Our Bodies?
Copyright Tiffany Blackden 2012 All Rights Reserved
Deactivation AND Liver Deactivation AND Liver MetabolismMetabolism
Enzymes that BREAK DOWN Histamine:
oDAO (Diamine Oxidase)oHMT (Histamine Methyltransferase)oMAO A (Monoamine Oxidase A)
Phase I & II Liver DetoxificationoMethylationo SulfationoOxidation
Copyright Tiffany Blackden 2012 All Rights Reserved
Histamine Liberating or Histamine Liberating or DAO Inhibiting MedicationsDAO Inhibiting Medications
Substance class Some Active agents Radiological Contrast media Muscle relaxants Pancuronium, Alcuronium, D-Tubocurarin Narcotics Thiopental Analgesics Morphine, pethidine, NSAR, ASS,
metamizole Local anesthetics Prilocaine Antihistamines Dyphenhydramine Antihypotensives Dobutamine Antihypertensives Verapamil, alprenolol, dihydralazine Antiarrhythmics Propafenon Diuretics Amiloride Motility agents Metoclopramide Antibiotics Cefuroxime, cefotiam,
isoniazid,pentamidine, clavulanic acid, chloroquine Mucolytics Acetylcysteine, ambroxol Broncholytics Aminophylline H2 receptor antagonists Cimetidine Cytostatics Cyclophosphamide Antidepressants Amitriptylline Copyright Tiffany Blackden 2012
All Rights Reserved
Ways to Help the Liver Flush Ways to Help the Liver Flush HistamineHistamine
Reduce overall chemical load.
Move lymph in our bodies.Lower your stress level.Drink lots of clean water.Get adequate nutrients for detoxification.
Copyright Tiffany Blackden 2012 All Rights Reserved
Some doctors in Europe treat Some doctors in Europe treat DAO deficiency as a DAO deficiency as a progressing disease progressing disease
process…process…
MastocytosisMCAD
Hypersensitivity DisorderHistaminosis
Histamine Intolerance
Copyright Tiffany Blackden 2012 All Rights Reserved
Our Low Histamine Our Low Histamine StrategiesStrategies
Copyright Tiffany Blackden 2012 All Rights Reserved
Mast Cell – Histamine Mast Cell – Histamine DiariesDiariesFoods (Sensitivities/Histamine/Glycemic
Index)Beverages (Hydration
Level/Dyes/Sweeteners)Exposures
(Pollen/Stores/Chemicals/Smells)Reactions (Type/Duration/Medication)Sleep (Amount/Quality)Emotional State
(Anxious/Depressed/Happy/Stressed)
Copyright Tiffany Blackden 2012 All Rights Reserved
Our High Quality NutritionOur High Quality Nutrition
Drink plenty of good quality water every day.Low Histamine/Tyramine, Organic Whole Foods
(locally grown when possible)Rotate FoodsNo Gluten/Dairy/Soy/Eggs/Nuts/Citrus/Dyes/Additives
Preservatives/Polyunsaturated FatsOnly grass fed beef and wild caught fishGood quality fats daily(No PUFAs) Digestive EnzymesSources of Trace Minerals (Pink Himalayan Salt,
Dulse Flakes, Superdupermineralpackedwheatgrass juice)
Some High Quality SupplementsRaw Leafy Greens (methylation support)
Copyright Tiffany Blackden 2012 All Rights Reserved
Daily Health SupportDaily Health SupportHydration, Hydration, HydrationDense NutritionEpsom Salt Baths Daily (Additional
Magnesium Chloride Spray as Needed)Moderate Exercise-Play, Mini
TrampolineClean AirGood Quality SleepLimit All Man-made Chemical Exposure
PossibleAyurvedic-Style Meal Preparation12 Hour Night FastLow Stress Copyright Tiffany Blackden 2012
All Rights Reserved
Get in touch, get Get in touch, get support…support…
Tiffany Blackden on Facebook or Twitter
Tiffany@YogaDeepCreek.com
Join Facebook Group: “Mastocytosis – Holistic Approach”
Our FB page for our medical journey & research:
www.Facebook.com/blackdenfamilyCopyright Tiffany Blackden 2012 All Rights Reserved