John J. Lanza, MD, PhD, MPH, FAAP Florida Department of Health

A Public and Clinical Health Perspective

American Ebola Patients

Dr. Brantley Arriving at Emory (Early August, 2014)

Dr. Brantley Leaving Emory (Aug. 21, 2014)

Objectives

• To review the epidemiology of Ebola

• To understand the transmission risk from the Ebola virus

• To review the infection prevention and control recommendations for Ebola patients

• To understand the therapeutic options for Ebola patients

Virus Classification

Group: Group V (-)ssRNA. Order: Mononegavirales

Family: Filoviridae Genus: Ebolavirus

• Ebola’s natural reservoir is unknown.• Non human primates have been the source of

human infections but are not thought to be the reservoirs.

History• Named after the Ebola River in the Democratic

Republic of the Congo (formerly Zaire), near the first epidemics.

• Two species were identified in 1976:

– Zaire Ebolavirus (ZEBOV) and

– Sudan Ebolavirus (SEBOV)

• Case fatality rates of up to 83% and 54%, respectively.

• A third species, Reston Ebolavirus (REBOV), was discovered in November 1989 in a group of monkeys (Macaca fascicularis) imported from the Philippines.

• Ivory Coast Ebolavirus – Only one case in an unlucky scientist.

Current Outbreak Problems• Nothing unusual about the virus

• Dysfunctional public health and medical system

• Lack of local and international government actions

• Population does not understand the disease and its dangers & what to do

W E S T A F R I C A Ebola Outbreak

Ebola Cases and Deaths (West Africa) (Updated: Sept. 29, 2014)

• Suspected and Confirmed Case Count: 6574

• Suspected Case Deaths: 3091

• Laboratory Confirmed Cases: 3626