Post on 26-Oct-2014
Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
Lauren HuangPeriod 4
Overview• Purpose
• History
• Procedures– Steps– Video
• Applications
• Questions Figure 1. Inside of an ICP-MS machine.http://www.wcaslab.com/tech/tbicpms.htm
PurposeTo determine the concentration of trace elements in a sample with high sensitivity.
Figure 2. Analyzable elements.http://www.perkinelmer.com/PDFs/Downloads/tch_icpmsthirtyminuteguide.pdf
History• Mass spectrometry
• Atomic absorption spectroscopy (AAS)
• Inductively coupled plasma optical emission spectrometry (ICP-OES)
• Interference
Figure 3. Absorption and Emission Spectra.http://socphysics.blogspot.com/2010/08/hydrogen-emission-and-absorption.html
Steps: Introduction of the Sample
• Nebulizer: Liquid to aerosol
• Laser ablation: Solid to vapor
Figure 4. Laser ablation.http://www.appliedspectra.com/technology/LIBS.html
Steps: Atomization & Ionization• Argon plasma (6,000 - 10,000oC)
• Sample to atoms (atomization)
• Atoms to ions (ionization)
Figure 5. Argon plasma.http://www.cee.vt.edu/ewr/environmental/teach/smprimer/icpms/icpms.htm
Steps: Separation• Voltage applied to rods
• Ions removed by mass-to-charge ratio
Figure 6. Removal of ions.http://www.cee.vt.edu/ewr/environmental/teach/smprimer/icpms/icpms.htm
Steps: Detection• Dynode
• Signal amplification
Figure 7. Electron multiplier.http://www.cee.vt.edu/ewr/environmental/teach/smprimer/icpms/icpms.htm
Procedures
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1. Introduction of the sample
2. Atomization/Ionization
3. Separation
4. Detection
http://www.chem.iastate.edu/faculty/Robert_Houk/research
and Analysis
Video of Procedureshttp://www.youtube.com/watch?v=MQqtV2oiC6U&t=1m38s
Applications• Soil/water analysis
• Toxicology
• Isotopic ratios
• Radiometric dating
Figure 8. ICP-MS Machine in Use.http://departments.colgate.edu/geology/instruments/icp.htm
Figure 9. Inside of an ICP-MS machine.http://www.wcaslab.com/tech/tbicpms.htm
Questions?
Works Cited• (2010, August 14). Hydrogen Emission and Absorption Spectrum. Message
posted to http://socphysics.blogspot.com/2010/08/hydrogen-emission-and-absorption.html.
• (2010, July). Inductively Coupled Plasma Mass Spectrometer Lab. Retrieved November 13, 2011, from Colgate University, Colgate Geology Web site: http://departments.colgate.edu/geology/instruments/icp.htm
• Applied Spectra, Inc. (2011). What is LIBS? Retrieved November 13, 2011, from http://www.appliedspectra.com/technology/LIBS.html.
• Houk, R. S. R. S. Houk. Retrieved November 13, 2011, from Iowa State University, Department of Chemistry Web site: http://www.chem.iastate.edu/faculty/Robert_Houk/research.
• Hunt, J. (2008, September 6). Celebrating 25 Years of Inductively Coupled Plasma-Mass Spectrometry. American Laboratory.
• PerkinElmer. (2011). The 30-Minute Guide to ICP-MS. Retrieved November 13, 2011, from http://www.perkinelmer.com/PDFs/Downloads/tch_icpmsthirtyminuteguide.pdf.
• West Coast Analytical Service. Metals Analysis by ICPMS. Retrieved November 13, 2011, from http://www.wcaslab.com/tech/tbicpms.htm.
• Worley, J., & Kvech, S. ICP-MS. Retrieved November 13, 2011, from http://www.cee.vt.edu/ewr/environmental/teach/smprimer/icpms/icpms.htm.