Restful Nights and Cheerful Days from Food Sourced

Tryptophan

Tryptophan Isolated in 1901Sir Frederick Hopkins

Tryptophan & Serotonin

Tryptophan

Step 1

+ OH

Step 2-COOH

Serotonin

Tryptophan Metabolism Is Light Dependent

Tryptophan

Serotonin

Melatonin

Control Mechanisms in Melatonin Synthesis

Pineal Gland

Pineal Cells•Similar in structure to retinal cells•Secrete melatonin at night•Secrete serotonin in the day

Julius Axelrod

Melatonin-Serotonin & Light

Serotonin

Superiour Cervical Ganglion

Melatonin

Supra Chiasmatic Nucleus

Melatonin-Serotonin & Light

Serotonin

Superiour Cervical Ganglion

Melatonin

Supra Chiasmatic Nucleus

5-HydroxyTryptophan 5-HTP

Tryptophan

Step 1

+ OH

Step 2-COOH

Serotonin

Tryptophan Usage/ 100,000 population

(NEJM 1990)

• Prior to FDA ban 2% of American Households used tryptophan in a regular basis

• The sales growth curve was exponential

0200400600800

1000120014001600

18002000

1980 1984 1988

Males

Females

Tryptophan Ban

• FDA based on cases of EMS• Before and after Showa Denka product• Genetics play a role?• Contamination plays a role?• Most likely some combination of genetics &

contamination

Tryptophan Available From Natural Sources But...

• Protein Sources Rich in Tryptophan decrease brain tryptophan levels.

BBB (Blood Brain

Barrier)

Transport Sites

Transport Sites

Transport Sites(Sites occupied)

• In fact a high protein meal increases blood levels of tryptophan but lowers brain levels

Tryptophan level

Serotonin level

• Carbohydrates prompt the pancreas to create insulin

• Insulin reduces the blood level of all amino acids except for tryptophan

• Tryptophan levels rise relative to other amino acids

Carbohydrate

=

Insulin

• Carbohydrates reduce blood levels of all amino acids except for tryptophan

Finding the right protein

+

=

• Zenbev increases the serotonin level in the brain

• With Zenbev, brain levels of tryptophan go up as blood levels go up

Zenbev Tryptophan=

Anxiety level

Serotonin level

At night, serotonin turns into melatonin

Increase in serotonin

Melatonin =

Sleep StudyNutritional Neuroscience

Chronic Insomnia

RestBites Tryptophan + Carbohydrate Carbohydrate

Protein Source Tryptophan versus Pharmaceutical Grade Tryptophan as an Efficacious Treatment for Chronic Insomnia

Anxiety StudyCanadian Journal Of Physiology & Pharmacology

Social Phobia

RestBites Carbohydrate

Protein-source tryptophan as an efficacious treatment for social anxiety disorder: a pilot study

Eat 1 chocolate ½ hour before bedtime. Try this for three nights and if required, increase by 1 chocolate until the desired effect is achieved.

•90 calories per square•Low Fat (2.5 g)•0 Trans Fats•Caffeine Free•Low Sodium

Ingredients: Partially Defatted Deoiled Organic Pumpkinseed Flour, Organic Agave

Nectar, Sugar, Chocolate Coating, Caramel, Sunflower Oil, Water, Agar, Soybean Oil, Soy Lecithin – Caffeine Free

FAQ’s

• What if I take Zenbev during the day, will I get sleepy?

• Can’t I just eat some pumpkin seeds?

• Why does this have Dextrose in it? • I took some Zenbev last night and I

did not sleep any differently. Why?• What is the difference between this

and l-tryptophan?• Is this different than the tryptophan

that was banned a couple of years ago?

Amide Form

Amine Form

Benefits• Promotes Deep, Restful Sleep and Daytime Calm

• No Hangover effect in the morning

• Return to sleep easily after waking up in the night

• No risk of dependence or tolerance

• Replace Daytime Stress with a sense of calm control

• Organic Ingredients

• Clinically Proven effective

• Patented product