Host-Parasite Relationship

• Normal Flora• Pathogens• Infections• Opportunistic• pathogens

Skin Flora

• 180 species• Streptococcus• Staphylococcus• Propionibacterium• Body Odor• Acne

Oral Cavity Flora

• Plaque• Anaerobes• Biofilms• Dental Caries• Streptococcus

mutans, sobrinus• Sucrose

Tongue

Intestinal Tract

• Stomach – pH • Helicobacter pylori

• Small Intestine• Enterococci, Lactobacilli

Large intestine

• 1010-1011 cells/gm• Bacteroides• Enterobacteria

•Escherichia coli•Enterococcus

Large Intestine Flora

•Methanogens•Food passage 24 hrs•Excrete 1013/day•Probiotics•Fecal transplant

Respiratory Tract

• Staphylococcus aureus

• Streptococcus pneumoniae

• S. pyogenes• Corynebacterium

diphtheriae• Carrier

Opportunistic Pathogens

E. coli

Virulence

Invasiveness

Toxicity

Lactobacillus acidophilus

Urogenital Tract

Adherence

• Specific Adherence• Capsule• Slime Layer• Glycocalyx• Fimbriae• Pili - longer

Invasiveness

• Colonization Factor Antigen

• Invasion• Colonization• Iron- Siderophore• Bacteremia vs.

Septicemia

Enzymes & Toxins

• Coagulase• Collagenase• Exotoxins• Cytolytic Toxins• Hemolysins, Leukocidins• Diphtheria Toxin• Botulism Toxin• Tetanus Toxin

Tetanus

Enterotoxin

Cholera toxin

Endotoxin – Pyrogen

LD50

Virulence Factors

Attenuated Strains

Other Toxins

Pyrogen free Products

Virulence Factors

Nonspecific Host Defense

• Natural Resistance• Age• Stress• Diet• Anatomical

Defenses• Skin, Stomach,

Tears

Compromised Hosts

Inflammation

Fever

Nosocomial Infections

Host-Parasite Word List

Normal Flora

Pathogens

Infection

Skin Flora

Staphylococcus, Propionibacterium

Oral Cavity Flora

Plaque

Streptococcus spp

Dental Caries

Streptococcus mutans

Intestinal Tract

Stomach – pH2

Helicobacter pylori

Small Intestine

Enterococci, Lactobacilli

Large Intestine

1010- 1011 cells/gram

Host-Parasite Word List 2

1010- 1011 cells/gram

Bacteroides, Enterobacteria,

Escherichia coli, Enterococcus

Respiratory Tract

Staphylococcus aureus,

Streptococcus pneumoniae,

S. pyogenes, Corynebacterium diphtheriae

Carrier

Urogenital Tract

Opportunistic Pathogens

Virulence

Invasiveness, Toxicity

Specific Adherence

Host-Parasite Word List 3

Capsule, Glycocalyx,

Slime Layer

Fimbriae, Pili

Colonization Factor Antigen

Invasion

Colonization

Iron – Siderophore

Bacteremia – Septicemia

Enzymes & Toxins

Coagulase, Collagenase

Exotoxins

Cytolytic Toxins

Hemolysins, Leukocidins

Host-Parasite Word List 4

Diphtheria Toxin

Botulism Toxin

Tetanus Toxin

Enterotoxin

Cholera Toxin

Endotoxin

LD50

Attenuated

Nonspecific Host Defenses

Natural Resistance

Natural Resistance

Age, Stress, Diet

Anatomical Defenses

Skin, Stomach, Tears

Host-Parasite Word List 5

Compromised Host

Inflammation

Fever