Introduction to brain parcellation

Sarah GenonCognitive Neuroinformatics Lab

#BrainBFT

Brain parcellation

From histology

To multimodal MRI

#BrainBFT

Eickhoff, Yeo & Genon, 2018, Nat. Rev. Neurosci.

#BrainBFT

Connectivity-based parcellation (CBP)

Neuroimaging scanner

Connectivity

#BrainBFT

Type of

connecti

vity

Functional Co-plasticity Structural

(white matter)

Data Task-based fMRI Resting state fMRI Anatomical MRI Diffusion MRI

Approach Task-based:

Activation during

task

Resting-state:

Signal fluctuations at rest

Morphometry-

based:

Structural co-

variation in the

population

Diffusion-based:

Estimation of fiber

direction

Main

method

Meta-Analytic

Connectivity

Modeling (MACM)

Cross-timepoint correlation

in signal fluctuations

(RSFC)

Correlation of

local GM across

subjects (SC)

Probabilistic diffusion

tractography

(PDT)

0

1

study c

study a

study b

time

voxel A

voxel B

0

1

time

time

How to estimate connectivity ?

Eickhoff, Yeo & Genon, 2018, Nat. Rev. Neurosci.

VBM-es' mated' ssuevalues

VBM-estimated tissue value

#BrainBFT

CBP: how ?

1) Region of Interest:

Dorsal Premotor Cortex:

Interface between prefrontal and primary motor

Genon et al., 2017, Cerebral Cortex

2) Connectivity matrix

3) Clustering/factorization

#BrainBFT

Reordered similarity matrix

Convergence between connectivity modalities

study c

study a

study b

Genon et al., 2017, Cerebral Cortex

#BrainBFT

CBPtools for different connectivity modalities:

Reuter et al., submitted Poster # T580

#BrainBFT

CBPtools for different connectivity modalities:

Reuter et al., submitted Poster # T580

#BrainBFT

CBPtools for different connectivity modalities:

Reuter et al., submitted Poster # T580

#BrainBFT

Local microstructure VS

large-scale functional integration

Local microstructure Connectivity markers

#BrainBFT

Local microstructure Connectivity markers

Local microstructure VS

large-scale functional integration

Poster # T561

#BrainBFT

Local microstructure

Ding & Van Hoesen, 2015

Lateral medial

Connectivity markers

Local microstructure VS

large-scale functional integration

Poster # T561

#BrainBFT

study

cstudy

a

study

b

2k

3k

Plachti et al., in press, Cerebral Cortex

Local microstructure VS

large-scale functional integration

Poster # T561

#BrainBFT

Amunts et al., 2006 Plachti et al., in press

anterior

posterior

mediallateral

Local microstructure Connectivity markers

#BrainBFT

Local microstructure VS

large-scale functional integration

Poster # T561

study

cstudy

a

study

b

2k

3k

VBM-es' mated' ssuevalues

Plachti et al., in press, Cerebral Cortex

Local microstructure and

large-scale functional integration

Poster # T561

VBM-es' mated' ssuevalues

#BrainBFT

Take home messages

Brain parcellation

= a very wide set of methods to identify brain regions and/or networks

From histology to MRI-based connectivity

To understand or to represent brain organization and data

Convergence and divergence between mapping features

CBPtool as a user-friendly tool for connectivity-based parcellation to

• Examine replicability across samples

• Examine convergence across connectivity features

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THANK YOU

CASIA Beijing

Lingzhong Fan

Düsseldorf

Katrin Amunts

Svenja Caspers

Holger Schwender

s.genon@fz-juelich.de

@fzj_inm7

Simon Eickhoff

Cognitive Neuroinformatics Lab

WashU

Aris Sotiras

#BrainBFT

#BrainBFT

#BrainBFT