Post on 14-Dec-2015
Gene expression
Chapter 15
Genes and Development
Central dogma
1956 version of Central dogma by Francis Crick
Central dogma
1958 version of Central dogma
Genetic code
Genetic code
Transcription
DNA
P’ase
RNA polymerase-3D at Online Macromolecular Museum
Transcription
Transcription
RNA polymerase-3D at Online Macromolecular Museum
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
E1 I1 E2 I2 E3 I3 E4 I4
Transcription
Introns are removed
Exons
Introns
Mature mRNA
3’ poly-A tail5’ cap
5’ cap 3’ poly-A tail
Primary RNA transcript
DNA template
Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
E1 I1 E 2 I 2 E3 I3 E 4 I 4
Transcription
Introns are removed
Intron
Exon
DNA
1
2 34
5 67
a.
b. c.
Exons
Introns
mRNA
Mature mRNA
cap ׳poly-A tail5 ׳3
cap ׳5 poly-A tail ׳3
Primary RNA transcript
DNA template
b: Courtesy of Dr. Bert O’Malley, Baylor College of Medicine
Translation
Genetic code