Dr. Brian J. Spieringemail: bspiering@gmail.com

website: brianspiering.com

5 fMRI Research Wins

5 fMRI Research Wins1) Have a Theory

2) Build a Behavioral Base

3) Design, Redesign

4) Create an Analysis Hitlist

5) Make Writing Fast (& Fun)

1) Have a Theory

A theory can be proved by experiment;but no path leads from experimentto the birth of a theory.

- Manfred Eigen

- Begin with the neuroanatomy

- Account for previous results

- Make specific, falsifiable predictions

1) Have a Theory

Ashby et al. (1998) Ashby, Paul, & Maddox (2011)

COVIS (Competition Between Verbal and Implicit Systems)

SPEED (Subcortical Pathways Enable Expertise Development)

Ashby, Ennis, & Spiering (2007)

Pessoa & Adolphs (2011)

Pessoa (2011)

Pessoa (2011)

2) Build a Behavioral Base

All life is an experiment.The more experiments you make the better.

- Ralph Waldo Emerson

2) Build a Behavioral Base

- Understand the literature

- Pick the low hanging fruit

- Simplify, simplify, simplify

Category Learning Task

Category Learning Stimuli

Unstructured Categorization

Rule-Based Categorization

Information-Integration Categorization

Experiment 1 - Within

Experiment 1 - Within

Training Accuracy

Experiment 1 - Within

Transfer Accuracy

Experiment 2 - Between

Experiment 2 - Between

Training Accuracy

Experiment 2 - Between

Transfer Accuracy

3) Design, Redesign

Design is not just what it looks like. Design is how it works.

- Steve Jobs

3) Design, Redesign

- Define project outcome

- Thrash Now

- Create a devil’s advocate

fMRI Methods

Results

Results

Results

ResultsResults

4) Create an Analysis Hitlist

It's not the plan that is important,it's the planning.

- Dr. Graeme Edwards

4) Create an Analysis Hitlist

- Door wide open

- Think through all steps

- 2 week sprints

Expectancy violation in cadence perception

Standard Ending

Deceptive Ending

Modulation Ending

Atonal Ending

Music-related Activations

Music > Silence Baseline

Ending-related Activations

All Ending > Music Baseline

Cortex Activation by Ending

Anatomical ROIs

Standard Ending - .01

Deceptive Ending - .02

Modulation Ending - .05

Atonal Ending - .99

Parametric Regressor

Basal Ganglia Parametric Activation

Granger Causality Modeling

5) Make Writing Fast (& Fun)

The faster I write the better my output.If I’m going slow I’m in trouble.It means I’m pushing the words instead of being pulled by them.

-Raymond Chandler

Analysis Paper

Door Open Door Closed

Team Single Advocate

Compile Winnow

Smith, Ashby, Berg, Murphy, Spiering, Cook, & Grace, 2011

F. Greg Ashby Carol A. Seger

Erik J. Peterson

Dan Lopez-Paniagua

Kurt Braunlich

Anastasia SaresAlexander Gonzalez

Catie AlpeterSarah Quraini

Collaborators