FcɛRI Signalling Pathway

The Ligand : IgE

Mast and Basophil Cells

• Fc receptors bind tail region of IgE antibodies.

•Histamine, proteases,

The Receptor

Tyrosine Kinases

Lyn

Syk

The Pathway

•Binding of IgE•Aggregation of receptors

Syk activation Cascade of reactions Degranulation

Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor.

Syk can also phosphorylate syk associated with adjacent receptor

Allergy sufferers are at a lower risk of developing cancer

•Inverse association between IgE and malignancies

•IgE-mediated immune responses against tumor cells

•IgE-based treatment options

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LevelHistogram not generating all first passage times

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But it wasn't so bad

Bngl easy to understand Easy to define chemical

reactions Can manipulate molecule

concentrations Can set time period of reaction