Post on 09-Jan-2016
description
Evidence for a New Theory of Allostery
Andrew MichaelsonNortheastern UniversityProfessor Mary Jo OndrechenEvidence for a New Theory of Allostery
Andrew MichaelsonNortheastern UniversityProfessor Mary Jo Ondrechen
Why Do We Want to Do This?
New DrugsDesign of new sitesDesign of new effectors(Understanding allosteric effects may be lead us to design allosteric sites and effectors for non-allosteric enzymes)
Current Theory of Allostery
Concerted Model
Sequential Model
A Classic Example
Uracil PhosphribosyltransferaseWhat does it do?
Why is this important?
MethodsTHEMATICS
PropKa
Motif
Uracil Phosphoribosyltransferase(Inactive Form)
Uracil Phosphoribosyltransferase(Active Form)
But Are They Different?(0.679 Angstroms)
Uracil Phosphoribosyltransferase(Inactive Form)
Uracil Phosphoribosyltransferase(Active Form)
And How Are They Different?(1.743 Angstroms)
Results
Results
Results
Analysis
Results
Analysis
Conclusions
AcknowledgmentsI would like to thank Professor OndrechenI would like to thank the Ondrechen Group.I would like to thank all the other people working on the Allostery project as well.
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