Post on 21-Dec-2015
Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted
Imaging
Lakshman Gollapalli
Huntington’s Disease (HD)
• Huntington’s disease is a dominantly inherited degenerative disease of the CNS
• The pathological features include atrophy of the CN, chorea and neuronal loss
• Changes in caudate volume have been documented in MRI studies
Susceptibility Weighted Imaging (SWI)
• SWI exploits the magnetic susceptibility effects generated by local field inhomogeneities
• Signals from tissues with different susceptibilities compared to their neighboring tissue will become out of phase
• New type of contrast
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PHASE PLOT