Epigenetics - National Cancer Institute · 5-azacytidine, valproic acid and ATRA. Histone...

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Epigenetics

Epigenetics

DNA and destiny

Cancer Survivors

Cancer continuum

Cancer development

Cancer and age

Paradigm shift

Genome landscape

Cancer genes

GWAS hits

Genome wide associations

Genome sequence

Kornberg and nucleosome

DNA methylation

Epigenetics

Epigenome components

Methylation

Mechanism

Chromatin modifications

Exercise

Environment and development

E-cigarette vapors

Cancer etiology

EGRP studies

Cohort consortium

Early life exposure

Scientific goal

ECHO advantages

Epigenetics and behavior

Toxicoepigenomics

Tumor alterations

Genetic mutations

DNA methylation and carcinogenesis

Integrin signaling

Methylation

Histone acetylation

Micro RNA signatures

Micro RNA methylation

Extracellular vesicles

Histone modifications

Histones

Histone H3 modifications

Epigenetic regulation

Single cell epigenomics

Histone modifications

Books

Epigenetic changes

Epigenetic drugs

Exfoliated cells

Histone enzymes

Methylation and acetylation enzymes

HDAC inhibitors

Phase I study

5-azacytidine, valproic acid and ATRA

Histone inhibitors

Environmental damage

Epigenetic inhibitors

Approved epigenetic drugs

Epigenetic drugs

Combination therapy

Epigenetic therapy

Combination epigenetic therapy

Low doses of DNA-demethylating agents

Intervention

Microsatellite instability

Tumor clusters

Genetic analysis

Methylation analysis

Epigenetic markers

Mesothelioma

Epigenetic pattern

Esophageal cancer

Pancreatic cancer

Chromatin states

Breast cancer

Organic viruses

DNA methylation

HPV and methylation

Methylated genes

Immune system and epigenetics

Biomarkers

Bladder cancer methylation

CpG island hypermethylation

Anticancer phytochemicals

Key points

Carcinogenesis

Hepatocellular epigenetics

Epigenetic foods

Research opportunities

How to address challenges

NIH Roadmap

Roadmap

Epigenome consortium

IHEC

Molecular profiling

Ongoing programs

NIH