ENDOKRINOLOGI ENDOKRINOLOGI REPRODUKSIREPRODUKSI

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Laksmindra FitriaEdit by Ali Machrus

a5krus@yahoo.co.id

Regulasi hormoneRegulasi hormone

Aksis HPTAksis HPT Aksis HPOAksis HPO

= fase proliferatif= fase proliferatif = fase sekretorik

Note

Tubulus Seminiferus

Genitalia interna (M)Genitalia interna (M)Spermatozoon

Spermatogenesis

GonadGonad

Gonad jantan testisGonad betina ovarium

Gonad Sistem reproduksi gamet:- Testis spermatozoa- Ovarium ova

Gonad Sistem endokrin hormon seks:- Testis androgen- Ovarium estrogen, progestogen

Aksis HPTAksis HPT

Hipotalamus GnRH

Hipofisis Gn (FSH, LH)• FSH

target: sel Sertoli - ABP: T DHT tub.seminiferus spermatogenesis

- inhibin/folikulostatin/SCF sirkulasi darah feedback

• LH (ICSH)

target: sel Leydig steroidogenesis - androgen (T) sel Sertoli spermatogenesis

- androgen sirkulasi darah efek androgenik

Efek Testosteron- Virilisasi/Maskulinisasi (Androgenik)- Tropik/Metabolisme (Anabolik)- Rekreasi (Dopping)

Aksis HPOAksis HPOHipotalamus GnRH

Hipofisis Gn (FSH, LH)

• FSH

target: sel granulosa (folikel ovarium)

- estrogen folikulogenesis, oogenesis

- inhibin sirkulasi darah feedback

• LH

target:

- sel teka interna steroidogenesis ~ androgen sel granulosa estrogen

~ estrogen sirkulasi darah efek estrogenik, feedback

~ pregnenolon sel granulosa progesteron (fase folikuler)

- korpus luteum progesteron (fase luteal)

Efek Estrogen

Genitalia interna (F)

Siklus ovariumOogenesis

Kondisi Hormonal Siklus MenstruasiKondisi Hormonal Siklus Menstruasi

SingkatanSingkatan

ABP = Androgen-Binding ProteinDHT = DihydrotestosteroneFSH = Follicle-Stimulating HormoneGn = GonadotropinGnRH = Gonadotropic-Releasing

HormoneICSH = Interstitial Cell-Stimulating

HormoneLH = Luteinizing HormoneSCF = Sertoli Cell FactorT = Testosterone