1Chief Technology Officer Confidential July 2016

Elisabeth Kogan

Head of InnoTech

Jan 2017Healthcare trends & Technology Innovation

2

Today

Confidential

3

Today

Elderly and chronic polypharmacy

- Elderly (65+) take 7 drugs/day

- 37% of population has 2+ chronic

conditions and take 10+ drugs/day

Confidential

4

Today

Elderly and chronic polypharmacy

- Elderly (65+) take 7 drugs/day

- 37% of population has 2+ chronic

conditions and take 10+ drugs/day

Unsustainable healthcare spending

- 3.2 trillion $ in US

Confidential

5

Today

Elderly and chronic polypharmacy

- Elderly (65+) take 7 drugs/day

- 50% don’t take their drugs properly

Unsustainable healthcare spending

- 3.2 trillion $ in US

Sub-optimal treatment outcome

- Poor adherence

- Safety: Drug-Drug Interaction, abuse, wrong drug

- Increased cost $100B/y (WHO)

6

Technology driven opportunities

Technologies

- Digital: wearable tracking devices,

Telemedecine, data analysis

- DNA: Pharmacogenomics

- New Delivery systems

From “patient” to “consumer”:

- Access to knowledge (google doctor)

- Managing own health (health apps..)

From inpatient to outpatient

Closed loop monitoring & dosing

Personalized medicine

Confidential

7

Long Acting Injectable – platform for chronic medication

Quarterly

• IR tablets• IR injectables

• Suspension/oily based LAR• Patch Pumps

• Microparticulate LAR • Polymer depot LAR

• Microparticulate LAR • Polymer depot LAR• Diffusion control

reservoirs

• Device Implants• Micropumps

Daily MonthlyWeekly Yearly +

Confidential

8

Smart implant – pharmacy inside body

Confidential

9

3D printing to deliver personalized pills

3D Printer Capsules

Drugs printed

• Right Dose for You

• Individual Drug

Combination

Confidential

10

Chip-on-pill

Confidential

11

Using sensors to personalize treatment and improve outcome

Wearables

Environment

Smart Pills & Packages

Confidential

12

Bioelectronics – electron as a drug?

Confidential

13

Nanorobotics

• Micro/Nanorobotics is the technology of creating machines in micro and nanometer scale 10-6 - 10-9

• Will be capable to navigate to a molecular/cellular target • Could carry active payload

Confidential

14

Drug

Delivery

Information& Services

Patient-focused Innovation

Confidential

15

15

You may say I'm a dreamer, but I'm not the only oneJohn Lennon

Thank You