DHA and Reproduction

S.Salehpour

Professor Ob/gyn

Infertility fellowship

Medical director

Gyn ward and IVF center

Taleghani hospital

SBMU

Tehran_ Iran

What is DHA?

summary

1. DHA and puberty

2. DHA and fertility

3. DHA and pregnancy

4. DHA and menopause

5. DHA and cancers

1. DHA and puberty

2. DHA and fertility

3. DHA and pregnancy

4. DHA and menopause

5. DHA and cancers

• DHA has neurodevelopmental benefits • DHA can reduce suseptibility to adolescence mood

disorders ( jour of lipid research_2015)

• Diet rich in fatty fish, meats, eggs, fish oil is recommended

for teen ages • Positive role for EPA in the treatment of adult depression (Grosso et al 2014)

• DHA ↑ plasma serotonin and melatonin • Supplementation with DHA is important after weaning ( jour of lipid research- 2015)

1. DHA and puberty

2. DHA and fertility

3. DHA and pregnancy

4. DHA and menopause

5. DHA and cancers

DHA and spermatogenesis

• DHA ↑ cell membrane flexibility better cell function and maturity

• ↓ DHA in mice ↓ sperm morphology (JBC 2017)

• ↓ DHA ↑ cytoplasm around sperm head • ↓DHA ↓ sperm endocytosis • Level of DHA is increased from spermatogonia to

spermatocyte and might play a role in sperm differentiation

(JBC 2017)

DHA and seminal plasma

• ↑AA/ DHA in seminal plasma ↑ infertility (clini nut 2010)

• DHA has anti inflammatory effect ( j nutr 2008)

• Antioxidants ↓AA/ DHA ↑ clinical pregnancy rate in IVF

( biomed papmed 2015)

• DHA restores all impairement of male reproduction

• DHA supplementation restores fertility and spermatogenesis in mice

( j lipid res 2010)

DHA and oogenesis

• EPA and DHA ↓ ovarian PG E2 enhance ovulation

(science direct 2009)

• DHA supplement ↑PG E3 and PGF 3α in ratsbetter ovulation

( science direct 2009)

• PUFA supplement ↑ steroidogenesis ( j Rep inf 2014)

• Omega 3 and PUFA supplement better ovulation

(ferti steri supp 2011)

Effect of PUFA on fertilization in ICSI

PUFA supplement in female

↑ fertilized oocytes

↑ good quality embryos

↑ implantation and pregnancy rate

DHA and endometriosis

PUFA supplement

• ↓ endometriosis volume

• ↓ interleukin- 6

• ↓ TNF -α

• ↓ VEGF

1. DHA and puberty

2. DHA and fertility

3. DHA and pregnancy

4. DHA and menopause

5. DHA and cancers

DHA during embryogenesis • PUFA improve brain

development and function ( poult sci 2017) • DHA is incorporated into

brain and retina during the last trimester and first two years of life

• Higher prenatal fish

consumption in pregnancy improvement of neurodevelopment in offspring

• Fish consumption = methylmercury exposure

• Mercury toxicity in pregnancy neurodevelopmental delay in children

(Amj epid 2008)

• Fish consumption ↓ preterm birth ↑ birth weight

DHA in pregnancy

• Neurodevelopmental benefits

• ? ↓ preterm birth

• ↓ asthma and allergy in offspring ( current opi 2012)

• No decrease in IUGR, preclampsia, GDM (Amj clin nut 2007)

• ? No decrease in peripartum depression ( Br j nut 2010)

• 200-300 mg /day DHA in pregnancy

• Optimal visual and cognitive development in offspring

1. DHA and puberty

2. DHA and fertility

3. DHA and pregnancy

4. DHA and menopause

5. DHA and cancers

DHA in menopause

• DHA modulate perimenopausal symptoms and improve quality of life, and sexual life

• DHA improve audiometric indices in perimenopause

1. DHA and puberty

2. DHA and fertility

3. DHA and pregnancy

4. DHA and menopause

5. DHA and cancers

• DHA consumption during adolescence and midlife

↓ decrease breast cancer

Thanks for your attention