David J. Grelottia, Ami J. Klina, Isabel Gauthierb, Pawel Skudlarskic, Donald J. Cohena, John C....

David J. Grelottia, Ami J. Klina, Isabel Gauthierb, Pawel Skudlarskic, Donald J. Cohena, John C. Gored, Fred R. Volkmara, Robert T. Schultz

fMRI Activation of the Fusiform Gyrus and Amygdala to Cartoon Characters but not to Faces in a boy with Autism

Laura Kwon

What is Autism?

Pervasive Developmental Disorder (PDD) social impairments deficits in language development stereotypic or repetitive behaviors

Face perception deficit Relates to social impairments

Different way of perceving faces Hypoactivation in the Amygdala and

Fusiform Face Area (FFA)

• Autistic person - Smaller and more densely packed neurons

• Damage in Amygdala - Deficits in emotion perception

Fusiform Face Area (FFA) Amygdala

• Composed of…- Middle fusiform gyrus (FG)- Occipito-temporal visual cortical area

• Most activated by the human face• Damage in FFA - Prosopagnosia

Hypothesis

FFA & Amygdala of autistic individuals would respond to their special interests despite a lack of activation to faces

Previous findings - expertise

Methods

Participants DD (Autism+Digimon) – 11 yrs

- Expertise in Digimon CC (Autism) – 17 yrs

- No expertise/ interest in digimon/ pokemon TDC (No Autism+Pokemon) – 10 yrs

- Expertise in Pokemon, but knew of digimon

Procedure1. Forced-choice verification task (Behavioural Response)2. Neuroimaging task (fMRI)

Method - Neuroimaging task

2 sessions (E1) DD & CC

- Unfamiliar faces

- Digimon

- Nonface objects (E2) DD & TDC

- Familiar faces

- Unfamiliar faces

- Digimon

- Nonface objects

( )( )3.9s

Stimulus Stimulus Stimulus Stimulus Stimulus(( ((

1 Block

Same or Different

Results - DD

FFA- No activation to

unfamiliar faces

- Significant activation to Digimon

Amygdala- Showed bilateral

activation for Digimon

Results

DD; FFA & Amygdala responded more to Digimon than to faces or objects

Neither TDC nor CC had greater activation to Digimon than objects or faces

Discussion

FFA “Face Module” damaged Expertise

Amygdala DD found Digimon emotionally meaningful (more

salient and rewarding than human face)

Conclusion

FFA and Amygdala of Autistic individuals function normally under certain conditions

Personal Opinion

Strengths Real life application Various approach

Limitations Subjects – small #, not well matched Technical difficulty – part of results lost due to malfunction

of the devices Next Step?

Other special interest or expertise? Explore possible treatment for autism?

Thank you for listening!

Questions?

David J. Grelottia, Ami J. Klina, Isabel Gauthierb, Pawel Skudlarskic, Donald J. Cohena, John C....

Documents

Transcript of David J. Grelottia, Ami J. Klina, Isabel Gauthierb, Pawel Skudlarskic, Donald J. Cohena, John C....

String Quartet in G - Free-scores.com · 1 2 1 2 1 2 9lrolq, 9lrolq,, 9lrod 9lrorqfhoor j j 0rowr$oohjur j j j j j j j j j j j j j fuhvf j fuhvf j fuhvf j fuhvf g e 6wulqj4xduwhw

EG and Corporate Fraud: Is Public Opinion Reconcilable ... · Expectation Gap and Corporate Fraud: Is Public Opinion Reconcilable with Auditors’ Duties? Jeffrey Cohena, Yuan Dingb,

Fast extraction of minimal paths in 3D images and · PDF fileFast extraction of minimal paths in 3D images and applications to virtual endoscopy Thomas Deschamps , Laurent D. Cohena,b,

The limits of color awareness during active, real-world vision · 2020. 6. 2. · The limits of color awareness during active, real-world vision Michael A. Cohena,b,1, Thomas L. Botchc

Atrial Myxoma: A Case Presentation and Review · Atrial Myxoma: A Case Presentation and Review Ronny Cohena, b, d, Gagandeep Singhb, ... resection of the left atrium myxoma and left

Concerto in D minor for two violins and strings [BWV 1043] · e f g g g g g g j j j j j j j j pqp p j p p j j j pqp p j j m m pup k p p p p p j j j j j j t pqp p pqp p j j j j j p

Warranty Reserve: Contingent Liability, Informational ... · PDF fileWarranty Reserve: Contingent Liability, Informational Signal, or Earnings Management Tool?* Daniel Cohena, Masako

:J J J J 7:J5 d6;:y555:J J J J 7:J5 d6;:y555 ,))'J ( 67u8vJ2J>u>v ,))'J)( J#-J ,)(.J #(! 1#."J J )/ & J!& 4 1#( )1yJ #.. J1 , ,) -y #.. J , 1 ,-J ( J0 (#.3J/(#.y-#(!& J, # .),J ( J

REGIONAL POLICIES ON CLIMATE CHANGE AND ......8 DATOS KLINA MIT OBJECTIVES OF MITIGATION AND ADAPTATION 9 KLINA. OBJETIVOS DE MITIGACIÓN 2020 - 2030- 2050 KLINA MITIGATION OBJECTIVES

jjjjjjjjjjjjjjjjjjjjjjjjj j MANSI j · MANSI FINANCE (CHENNAI) LTD. 21st Annual Report 2014 - 2015 jjjjjjjjjjjjjjjjjjjjjjjjj jjjjjjjjjjjjjjjjjjjjjjjjj j j j j j j j j j j j j j j

Draft Buildout Analysis Results - Westchester 2025 Buildout Analysis Results ... jjjjjjj j? j j j j j j j jj j jj j j j j j j j j j j j j j j j j j j j j j j j j j jj j j j j j Village

ABB Safety relays · Safety relays C57x and C67xx range Content Selection table ... 3 J J J J J J J J J4) 4 J1) J1) J J J J J3) J7) J4) Connection single channel J J J - - J J - -

Towards formalizing the GDPR’s notion of singling out€¦ · 30/03/2020 · COMPUTER SCIENCES Towards formalizing the GDPR’s notion of singling out Aloni Cohena,b,1,2 and Kobbi

' j % + j j , j - Doing Business · j % + j j , j

of Breast Disease centers - AZ Klina 2015...9:30 - 10:30 session 10: UpDates on treatment for Breast cancer chairs : a. aWaDa (Belgium), m. espie (France), J. yarnoLD (UK) • Updates

Supermodular Functions and the Complexity of Max CSP · 2005. 10. 13. · Supermodular Functions and the Complexity of Max CSP? David Cohena, Martin Cooperb, Peter Jeavonsc, Andrei

The impact velocity and bone fracture pattern: Forensic … · 2016-11-17 · The impact velocity and bone fracture pattern: Forensic perspective Haim Cohena,b,*, Chen Kugelb,c, Hila

transportation printables - fancy shanty · jjjjjjjjjjjj j j j j j j jjjjjjjjjjjj j j j j j j jjjjjjjjjjjj jjjjjjjjjjjj j j j j j j jjjjjjjjjjjj j j j j j j jjjjjjjjjjjj jjjjjjjjjjjj

HE'S A PIRATE · PDF fileHE'S A PIRATE my-piano.info kokini.com. 2 r r 25 r r 31 r r 37 r r 43 j j j j j j j j j j j j j k j j j j j j j k j j k j k j j j k k j k j j r j j q j r j

ABB · D GOST J J J J K CB scheme J J E CCC J J J L RMRS J J J J J Marks a CE J J J J J J J J J J J J b C-Tick J J J J J existing j pending Cycle monitoring Thermistor motor protection