Post on 31-Oct-2014
description
Open Science Meets Personalized Health
David Ewing DuncanDirector, Center for Life
Science Policy, UC Berkeley
Two Great Movements
Citizen scientists
Citizen patients
Historical Moment
People
+ Technology
= Empowerment
“With great power comes great responsibility...”
- Ben Parker (Spiderman’s Uncle)
Why DIY?oCuriosity
oFeel it coming: early adopters
oOutmoded paradigms
oTired of hearing no
oBad customer service
oChange the world
THE EXPERIMENTAL MAN PROJECT
Age of Personalized Health
o10 million genetic markers
o9,366 genotypes
o 320 environmental toxins
o 22 hours of MRI brain scans
o ~ 2 liters of blood
o ~ $150,000
The Experiment
Healthy
Not Just Genes...
Environment
BrainBody
Experimental Family
Alzheimer’s (rs4420638)
Father Mother AG
AA
David Brother AA AG
Daughter AA
Heart Attack (rs1075728)
Father Mother AG AG
David Brother GG AA
Daughter AG
Favorite Genetic Marker
CYP1A2Caffeine Fast Metabolizer
Mercury and Me
Mercury and Me
Halibut (lunch) Swordfish (dinner)
Mercury and Me
Mercury Before: 4 ppb
Mercury After: 13 ppb
Chemical Gene Name
My Results
Impact/Disease
Methyl Mercury (MeHg)
GSTP1-125 AA > Risk of asthma, adverse drug response, cancers
MeHg GSTP1-114 CC > Risk of some cancers
Hg CPOX4 AC > Neurotoxic effects
Hg BDNF GG > Effects on cognition, mood, motor function
Hg COMT AA > Effects on confusion, coordination
My genetic sensitivity to mercury(Envirogenomics)
High Anxiety
Emotional incongruence (emotional conflict)
Emotional conflict resolution(emotion regulation)
Fear and Anxiety
(Don’t) Be Still My Beating Heart
Copyright 2008 Entelos, Inc.
First Add Genomics
Copyright 2008 Entelos, Inc.
Biomarkers (Chemistry)
Copyright 2008 Entelos, Inc.
Scans: Ultrasound and CT
Combine Risk Factors
Genes + Environment +Biomarkers + Ultrasound + CT Scan
Entelos Project
Copyright 2008 Entelos, Inc.
Prediction of my future… ?
Lost 10 pounds
oScience needs validatingoSkeptical public oResistance from traditional
medicineoExpensiveoShift from old to new
Still work to be done
Orwellian Possibilities
o Big Brother
o The Obama Effect
oDiscrimination
oGenetic thrallism (Gattaca)
oUnleashing monsters
o Fear
Personalized Health Project
o Coordinated effort to validateo Integration is keyo Get creative with law, policy,
education, ethics, mediao Private sector and early adopters o Encourage (demand?) a paradigm shift
Thoughts on DIY
o Dangers need to be taken seriously (credo of Ben Parker)
o Be proactive with government and law enforcement
o Work with Big Science – they need you, you need them
o Do something wonderful
Coming this fall…
The Linkage Project:A Manifesto
Still going… more tests
www.ExperimentalMan.com