Clayton Wiley, M.D./PhD

A 5-year-old girl presents with a ~6 week history of early morning headaches. Describe the findings in her MRI scan.

Question 1

T1

T1 plus contrast

T1 plus contrast

What is your major differential diagnosis for posterior fossa tumors in children?

Question 2

• Ependymoma• Pilocytic astrocytoma• Medulloblastoma

Answer

An intraoperative consultation was requested and performed via telepathology. Describe the findings in the intraoperative smear preparation on the following representative snapshots obtained via the telepathology system.

Question 3

What is your intraoperative diagnosis?

Question 4

Medulloblastoma

Answer

A resection of the mass was performed. Describe the findings in the following representative permanent H&E slide.

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Question 5

Describe the findings in the following immunohistochemical slides for synaptophysin and Ki-67.

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Question 8