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Chronic Liver Disease: History Symptoms of liver injury: fatigue, weakness, icterus, pruritis, dark urine, possible stool colour lightening, nausea, vomiting, RUQ discomfort, intolerance to dietary protein or cigarette smoke Symptoms of the consequences of cirrhosis: bleeding, cachexia, edema, ascites, encephalopathy, skin changes, gynecomastia etc.