Chemical Carcinogenesis

Jay P. Jazul, RPh, MSc., CPS University of Santo Tomas

Faculty of Pharmacy

University of Santo Tomas Faculty of Pharmacy

NON ORGAN-DIRECTED TOXICITY

Jay P. Jazul, RPh, MSc., CPS University of Santo Tomas

Faculty of Pharmacy

CHEMICAL CARCINOGENESIS

Ini$a$on

Promo$on

Progression

Indirect-acting

Alkylating neutrophiles

Alkyla&on

Frame-shift Mutations

Mutations

Mutation – caused by Radiations

Mutation

Protein structures and nucleic adducts

Selected carcinogenic polycyclic HC

DNA Repair Mechanism by base excision

DNA Repair Mechanism by nucleotide excision

Classes of Genotoxic Carcinogens: 1.  Polyaromatic Hydrocarbons (Benzo(a)pyrene) 2.  Alkylating Agents (Nitrogen mustards) 3.  Aromatic Amines and Amides

Nitrogen mustard (Alkylating agent)

Alkylating agent

Aromatic Amines

Inorganic Carcinogens

Non Genotoxic Carcinogens

Chemical Carcinogenesis

Documents

Transcript of Chemical Carcinogenesis

Chemical Carcinogenesis: Initiation, Promotion and Progressiondnomura/pdf/Lecture7... · 2013-09-22 · Types of mutations Chemical carcinogens can cause: 1. Point mutations- the

carcinogenesis 1

Long-Term Chemical Carcinogenesis Bioassays Predict Human ...

CHEMICAL CARCINOGENESISnjms.rutgers.edu/gsbs/olc/molonc/prot/2009/MolOncolCarcinogen2009.… · Factors that influence organ and species specific chemical carcinogenesis including

Cancer Etiology 1. Introduction 2. Chemical Factors in Carcinogenesis 3. Physical Factors in Carcinogenesis 4. Viral Oncogenesis 5. Genetic Predisposition.

EXTRAHEPATIC DRUG METABOLISM AND CHEMICAL CARCINOGENESIS · EXTRAHEPATIC DRUG METABOLISM AND CHEMICAL CARCINOGENESIS Proceedings of the International Meeting on Extrahepatic Drug

CARCINOGENESIS,1981 of and Interriational ERICE AT ...978-1-4684-4334-9/1.pdf · PARTICIPANTS AT ERICE ASI ON CHEMICAL CARCINOGENESIS,1981 (II Course of the Interriational School

Carcinogenesis - University of North Carolina at Chapel Hill · History of Chemical Carcinogenesis ... Environmental Agents Free Radicals Polymerase Errors CELL REPLICATION. Chemical

Chemical Carcinogenesis: Initiation, Promotion and Progression NST110, Toxicology Department of Nutritional Sciences and Toxicology University of California,

Chemical carcinogenesis - SciELO

Viral Carcinogenesis

Identification chemical that against carcinogenesis

CHEMICAL CARCINOGENESIS: A REVIEW v

Neoplasia & Carcinogenesis

Carcinogenesis Handouts

VIRUS CARCINOGENESIS

Carcinogenesis Last

MOLECULAR CARCINOGENESIS 1044-CH CHEMICAL VIRUS RADIATIONRADIATION Body Surface Deactivation Excretion Activation NORMAL CELL Inhibition Defects in Terminal.

Chemical Carcinogenesis and Nasopharyngeal Carcinoma

Chemical carcinogenesis - SciELO › pdf › aabc › v79n4 › a04v79n4.pdfdeath to a gradual process of chemical carcinogenesis. There are three stages involved in chemical carcinogenesis.