Certainty in Uncertain Times

4 April 2017

CertaintT™ is Only a Molecule Away™

NASDAQ: APDN

Applied DNA Sciences (APDN): Quick Facts

• Based in Stony Brook, NY in a 30,000 square foot facility

• 60 employees; 44 patents; 90 patent applications, globally

• Standards oriented:

o ISO 9001:2008 Certified/Registered

o ISO/IEC 17025:2005 Accredited

o Active member of JEDEC, SAE G19 and G21

• Over 104,000 unique DNA codes deployed globally

• Current government contractor: 3 DoD and 3 non-DoD Agencies

• 115 forensic cases successfully attributed to SigNature DNA evidence

• >160 million pounds of cotton marked with DNA

• USDA multi-year collaboration agreement on DNA barcoding of cotton

Commercial Ecosystems and the Evolution of our Platform

Plant-derived molecular tags

Massive Variety

Formulation and Stability Under Stress

DNA Recovery Systems

Validation Law Enforcement &

DOD

In-Field Authentication & Data Management

Data EncryptionMolecular Certificates

DNA Beacons

DNA - PCRMassive Scale

Large Commercial Ecosystems

Our Value Propositionsfrom Molecular Certificates that can not be falsified

Recover counterfeit

market shareTax savings

Sustainability Organic Fair TradeEthical Sourcing Circular Economy

Claims stay with the goods (not paper-trail or the package)

Origin Provenance PurityAuthenticity

Recover lost / stolen goods

Reduce legal risk

Molecular

Certificate™inalterable, unlike paper or e tracers,

travels as part of the product itself

DNA Secure ContentLinear Code in Molecular Polymer

Similar to Machine Code (but more

dense)

Our Lines of Revenue• DNA Tags and carriers

– “concentrate” for OEMs– “final products” for commercial businesses and consumers– “bulk volumes” for diagnostics and therapeutic OEMs

• DNA Tagging systems

• Authentication Solutions– Genotyping of natural commodities– Forensic laboratory services– Field equipment and services

• Online application to manage supply chain data

• Development and Consulting services

Supply Chain Protection

Three DNA-based Business Models

Bulk DNA for Diagnostics and Therapeutics

Crime Prevention and Security

Cash and valuables

safely transported.

DNA makes it

possible.

The use of DNA-marked

degradation dye in the UK has

resulted in a 75% reduction in

cash transport attacks.

114 Convictions

>500 Sentence Years

Recovered Steering

Wheel from Chop Shop

Sting in Stockholm

Location of

DNA

highlighted by

fluorophore

Supply Chain Protection

Three DNA-based Business Models

Bulk DNA for Diagnostics and Therapeutics

Crime Prevention and Security

Focusing on the

mission.

Delivering the best

outcome.

DNA makes it

possible.

Helping the Defense

Logistics Agency secure

its electronic microcircuit

supply chain.

Over 700 thousand

components marked.

The joy of sleepingin cool cotton comfort.DNA makes it possible.

Restoring integrity to the worldwide

cotton textile supply chain. Ensuring

quality, comfort and compliance.

160 million pounds of cotton marked.

DNA marking at cotton gins

8 gins on line; data transfer each

minute; DNA charge adequate to

tag 50 million lbs

Automated dilution for DNA

concentrate.

DNA added at 1 part per trillion

(ppt) of cotton.

DNA is activated on demand and

applied by aerosol during the

dehydration step.

An emblem of certainty

for any material, item or

product using the secure,

proven CertainT™ supply

chain platform to certify

claims to consumers.

RawMaterial Supplier

Manufacturer Distributor InspectorRetailer / Consumer

Authentication System of Record:Chain of custody | Geo-location | Authentication records | Documents and images |Reports, queries, alerts

Check the data…Be certified for tag, type and process

Tag and test at source

Authentication Every Step of the Way

Supply Chain CertainT™ Other sources

Design and Produce

Molecular Certificate

After SigNature T DNA

Marking Pima

compliance about 100%

The data speak for themselves...

Before SigNature T

DNA Marking Pima

compliance less than

30%

Use of SigNature T DNA eliminates fiber

substitution and yields a 100% compliant cotton

supply chain

CertainT™ for recycled PET

Why protect leather?

Verify claims: Sustainably produced

No deforestation

Controlled effluent discharge

Responsible use of chemicals

Animal welfare

Ethically sourced

No slave labour

Traceability: Protect upstream sustainability

credits beyond the split leather

trading process

Applied DNA Sciences, BLC Leather Technology Centre Ltd Announce Sponsorship by Five Global Brands to Develop Leather Traceability System

Project Sponsors Include C&J Clark International, PUMA and Three Other Global Brands

STONY BROOK, N.Y. March 30, 2017 — Applied DNA Sciences, Inc. (“Applied DNA,” NASDAQ: APDN), a provider of DNA-based supply chain, anti-counterfeiting and anti-theft technology, product genotyping and product authentication solutions, has signed a Research Agreement with BLC Leather Technology Centre (BLC). The intention of the Research Agreement is to develop and validate a robust SigNature® T-based system to provide comprehensive and verifiable leather traceability, from farm to finished products.

Supply Chain Protection

Three DNA-based Business Models

Bulk DNA for Diagnostics and Therapeutics

Crime Prevention and Security

Patented (US, Can, China, Israel, EUR {pending}) continuous flow

system, scaling PCR from micro-liters to liters

Unique Industrial-Scale DNA Production

• Vaccines, diagnostics, reagents, bio-

agriculture, and gene therapies for

existing and emerging markets.

• Clinical trial to commercial supply

Benefits of PCR at the Industrial Scale •Product Flexibility•No cellular contamination•Nucleic Acid Chemical Modification•Scalable Production•Reduced Lead Time•Cost-effective

Our Strategic Advisory Board

Bob Catell Gunther Faber Dr. MehmoodKhan

Ray Kelly

Thank you.

James Hayward, Ph.D., Sc.D.631-240-8800

james.hayward@adnas.com