Post on 24-Jul-2020
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CD123-ECD PNB20027Antibody
Specificity: HumanCD123Clone: SSDCLY107D2Isotype: IgG1mouse
The CD123 antigen, also known as Interleukin-3 Receptor a (IL-3Ra) belongs to thecytokine receptor family. It is expressed on dendritic cells, monocytes, eosinophils andbasophils.TheCD123antigenisalsoconstitutivelyexpressedbycommittedhematopoieticstem/progenitorcells,especiallyofthemyeloidlineage(CD13+,CD14+,CD33+,CD15low),andbysomeCD19+cells,itisabsentfromCD3+cells.
uMiyajima, A., «CDw123 (interleukin 3 receptor alpha chain)Workshop Panel Report», 1997, Leucocyte Typing VI,, WhiteCellDifferentiationAntigens.Kishimoto,T., et al,Eds.,GarlandPublishing,Inc.,854-855.
uMoretti, S., Lanza, F., Dabusti, M., Tieghi, A., Campioni, D.,Dominici,M.andCastoldi,G.L.,«CD123(Interleukin3receptoralphachain)»,2001,J.Regul.Homeost.Agents,,15,98-100.
uSato, N., Caux, C., Kitamura, T., Watanabe, Y., Arai, K-I,Banchereau, J., and Miyajima, A., «Expression and factor-dependentmodulationoftheinterleukin-3receptorsubunitsonhumanhematopoieticcells»,1993,Blood,82,752-761.
uMcClanahan,T.,Dalrymple,S.,Barkett,M.,Lee,F.,“Hematopoieticgrowthfactorreceptorgenesasmarkersoflineagecommitmentduringinvitrodevelopmentofhematopoieticcells”,1993,Blood,81,2903-2915.
uKorpelainen, E.I., Gamble, J.R., Smith, W.B., Dottore, M., Vadas,M.A., Lopez, A.F., “Interferon-gamma upregulates interleukin-3(IL-3) receptor expression in human endothelial cells andsynergizes with IL-3 in stimulating major histocompatibilitycomplex class II expression and cytokine production”, 1995,Blood,86,176-182.
uvandeLaar,L.,vandenBosch.A.,vanderKooij,S.W.,Janssen,H.L.,Coffer,P.J.,vanKooten,C.,Woltman,A.M.,“Anonredundantrole for canonical NF-κB in human myeloid dendritic celldevelopmentandfunction”,2010,JImmunol;185;7252-7261.
Antigen Characteristics
References
OtherName: IL-3Ra GeneLocation: Xp22.3orYp11.3GeneName: IL3RAMolecularWeight: 70kDa
Reagent
Line: IOTestFormat: LiquidSize: 0.5mLStatus: ASR
Example of Results
DS-17378A B2012-13538
Outside the US version
ASR:AnalyteSpecificReagent.Analyticalandperformancecharacteristicsarenotestablished.
BeckmanCoulter,thestylizedlogoandIOTestaretrademarksofBeckmanCoulter,Inc.andareregisteredintheUSPTO.
Main Functions
CD123binds IL-3with lowaffinity;whenCD123associateswithCDw131 (commonβchain),itbindsIL-3withhighaffinity.CD123doesnottransduceintracellularsignalsuponbindingIL-3andrequirestheβchainforthisfunction.
Normalwholebloodsample
Formats available
Size Volume Line Status Part#PE 100tests 2mL IOTest ASR A32535ECD 50tests 0,5mL IOTest ASR B20027PC5.5 50tests 0,5mL IOTest ASR B20022
Size Volume Line Status Part#PC7 50tests 0,5mL IOTest ASR B13647APC 50tests 0,5mL IOTest ASR B06376